A5038185169- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Healthcare Systems and Practices
- Diabetes Management and Research
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Retinal Diseases and Treatments
- Magnesium in Health and Disease
- Protease and Inhibitor Mechanisms
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Aortic Thrombus and Embolism
- Glycosylation and Glycoproteins Research
- Parathyroid Disorders and Treatments
- Genetic Associations and Epidemiology
- Acute Myocardial Infarction Research
- Advanced Glycation End Products research
- Lipid metabolism and biosynthesis
- Blood Pressure and Hypertension Studies
- Atherosclerosis and Cardiovascular Diseases
- RNA modifications and cancer
Université de Reims Champagne-Ardenne
2016-2025
Centre Hospitalier Universitaire de Reims
2016-2025
Centre National de la Recherche Scientifique
2013-2024
Hôpital Robert-Debré
2006-2024
Hôpital de la Conception
2022
European Atherosclerosis Society
2021
Fondation pour l’innovation en Cadiométabolisme et Nutrition
2016-2020
Sorbonne Université
2016-2020
Pitié-Salpêtrière Hospital
2016-2020
Assistance Publique – Hôpitaux de Paris
2001-2020
Although it has long been established that the extracellular matrix acts as a mechanical support, its degradation products, which mainly accumulate during aging, have also demonstrated to play an important role in cell physiology and development of cardiovascular metabolic diseases. In current study, we show elastin-derived peptides (EDPs) may be involved insulin resistance (IRES) mice. chow-fed mice, acute or chronic intravenous injections EDPs induced hyperglycemic effects associated with...
AimsBecause tobacco smoking is a major risk factor of mortality in diabetes and guidelines suggest evaluating behavior among individuals with helping smokers quit, we aimed to assess knowledge about the – relationship diabetologists cessation specialists (SCS).MethodsAn online cross sectional survey was conceived by Working Group on Smoking Diabetes, France. The questionnaire tested members deemed be completed less than 5 min. Only questions receiving highest number approval ratings were...
Apolipoprotein A-V (apoA-V) is an important regulator of plasma levels triglyceride (TG) in mice. In humans, APOA5 genetic variation associated with TG several populations. this study, we determined the effects p.185Gly>Cys (c.553G>T; rs2075291) polymorphism on subjects Chinese ancestry living United States and a group non-Chinese Asian ancestry. The frequency less common cysteine allele was 4-fold higher (15.1% vs. 3.7%) high-TG compared low-TG (Chi-square = 20.2; P < 0.0001), corresponding...
The metabolic syndrome (MetS) is a common disorder, where systemic insulin-resistance associated with increased risk for type 2 diabetes (T2D) and cardiovascular disease. Identifying genetic traits influencing progression of MetS important. We others previously reported functional HMGA1 gene variant, rs146052672, predisposing to T2D. Here we investigated the association rs146052672 variant related components. In case-control study from Italy Turkey, was seen among carriers variant. larger...
High-mobility group AT-hook 1 (HMGA1) is an important regulator of the insulin receptor gene. We have previously shown in three populations white European ancestry that HMGA1 gene variant rs146052672 (also designated IVS5-13insC) associated with type 2 diabetes mellitus (T2DM). The aim this study was to measure frequency and determine degree association T2DM other features metabolic syndrome a replication cohort Hispanic Americans.This retrospective well-characterized Hispanic-American...
Affecting more than 30% of the Western population, nonalcoholic fatty liver disease (NAFLD) is most common and can lead to multiple complications, including steatohepatitis (NASH), cancer, hypertension, atherosclerosis. Insulin resistance obesity are described as potential causes NAFLD. However, we surmised that factors such extracellular matrix remodeling large blood vessels, skin, or lungs may also participate in progression diseases. We studied effects elastin-derived peptides (EDPs),...
The aim of this study is to assess whether the family cascade screening strategy for identifying patients with heterozygous familial hypercholesterolaemia (HeFH) associated a reduction in cardiovascular events compared opportunistic strategies. We retrospectively included 3232 patients, from French FH registry, REFERCHOL, molecular diagnosis. according their HeFH: index cases (opportunistic screening) and (patients diagnosed by on clinical biological characteristics. first modality using χ²...
Abstract Sialic acids (SA) are monosaccharides that can be located at the terminal position of glycan chains on a wide range proteins. The post-translational modifications, such as N-glycan chains, fundamental to protein functions. Indeed, hydrolysis SA by specific enzymes neuraminidases lead drastic modifications behavior. However, relationship between desialylation and possible alterations receptor function remains unexplored. Thus, aim present study is establish impact removal from their...
This article presents three points of view on lipoprotein(a) [Lp(a)]: that a patient, his endocrinologist, and patient association, the Association Nationale des Hypercholestérolémies familiales et Lipoprotéines (a) (ANHET). By sharing story, reveals severe impact high Lp(a) levels had health, daily life, family. The endocrinologist explains what is its role as risk factor for cardiovascular disease. As an expert in field, he reviews recommendations screening management Lp(a). vice-president...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple Binding with Identical Linkage: A Mechanism That Explains the Effect of Lipoprotein(a) on FibrinolysisLaurence Hervio, Vincent Durlach, Anik Girard-Globa, and Eduardo Angles-CanoCite this: Biochemistry 1995, 34, 41, 13353–13358Publication Date (Print):October 17, 1995Publication History Published online1 May 2002Published inissue 17 October...
Objective — Small-sized apolipoprotein(a) [apo(a)] isoforms with high antifibrinolytic activity are frequently found in cardiovascular diseases, suggesting a role for apo(a) size atherothrombosis. To test this hypothesis, we sought to characterize the lysine (fibrin)-binding function of isolated variable sizes. Methods and Results Recombinant [r-apo(a)] preparations consisting 10 34 kringles monoclonal antibody that neutralizes lysine-binding were produced used parallel lipoprotein(a)...