A5027936436- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Prion Diseases and Protein Misfolding
- Neuroscience and Neuropharmacology Research
- Neurological diseases and metabolism
- Neurotransmitter Receptor Influence on Behavior
- Amyotrophic Lateral Sclerosis Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Parkinson's Disease Mechanisms and Treatments
- Health, Environment, Cognitive Aging
- S100 Proteins and Annexins
- Folate and B Vitamins Research
- Tryptophan and brain disorders
- Regulation of Appetite and Obesity
- Estrogen and related hormone effects
- Neurological Disease Mechanisms and Treatments
- Vitamin D Research Studies
- Bipolar Disorder and Treatment
- Advanced Differential Equations and Dynamical Systems
- Receptor Mechanisms and Signaling
- Alcohol Consumption and Health Effects
- Nutrition, Health, and Society Studies
- Health, Medicine and Society
- Sexual function and dysfunction studies
Inserm
2013-2025
Université Paris Cité
2015-2025
Sorbonne Paris Cité
2013-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Hôpital Fernand-Widal
2016-2025
Hôpital Lariboisière
2016-2024
Optimisation Thérapeutique en Neuropsychopharmacologie
2020-2023
FHU Neurovasc
2022
Sahlgrenska University Hospital
2022
Gordon Center for Medical Imaging
2022
Large genomic reference data sets reveal a spectrum of pathogenicity in the prion protein gene and provide genetic validation for therapeutic strategy disease.
Synaptic degeneration is a central pathogenic event in Alzheimer's disease that occurs early during the course of and correlates with cognitive symptoms. The pre-synaptic vesicle protein synaptotagmin-1 appears to be essential for maintenance an intact synaptic transmission function. Synaptotagmin-1 cerebrospinal fluid candidate Alzheimer biomarker dysfunction also may correlate decline.In this study, novel mass spectrometry-based assay measurement was developed, evaluated two independent...
The ε4 allele of apolipoprotein E (APOE) gene and increasing age are two the most important known risk factors for developing Alzheimer disease (AD). diagnosis AD based on clinical symptoms alone is to have poor specificity; recently developed diagnostic criteria biomarkers that reflect underlying neuropathology allow better assessment strength associations with AD. Accordingly, we examined global age-specific association between APOE genotype by using A/T/N classification, relying...
Abstract Background Amyloid pathology, which is one of the characteristics Alzheimer’s disease (AD), results from altered metabolism beta-amyloid (Aβ) peptide in terms synthesis, clearance, or aggregation. A decrease cerebrospinal fluid (CSF) level Aβ1–42 evident AD, and CSF ratio Aβ42/Aβ40 has recently been identified as most reliable diagnostic biomarkers amyloid pathology. Variations inter-individual levels Aβ1–40 have observed past, but their origins remain unclear. In addition,...
Abstract Introduction The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting results may differ, which can lead misunderstandings raises questions about commutability tests. Methods We obtained description (pre‐)analytical protocols sample reports 40 centers worldwide. A consensus approach allowed us propose harmonized comments...
Synaptic dysfunction is an early core feature of Alzheimer's disease (AD), closely associated with cognitive symptoms. Neuregulin 1 (NRG1) a growth and differentiation factor key role in the development maintenance synaptic transmission. Previous reports have shown that changes cerebrospinal fluid (CSF) NRG1 concentration are status biomarker evidence AD pathology. Plasma biomarkers reflecting impairment would be great clinical interest.To measure plasma patients comparison other...
The presynaptic protein neuregulin1 (NRG1) is cleaved by beta-site APP cleaving enzyme 1 (BACE1) in a similar way as amyloid precursor (APP) NRG1 can activate post-synaptic receptor tyrosine-protein kinase erbB4 (ErbB4) and was linked to schizophrenia. NRG1/ErbB4 complex neuroprotective, trigger synaptogenesis plasticity, increases the expression of NMDA GABA receptors, induce neuroinflammation. This reduce memory formation. In Alzheimer's disease (AD) brains, accumulates neuritic plaques....
Background Differential diagnosis between dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) is not straightforward, especially in the early stages of disease. We compared AD biomarkers (phospho-Tau 181 , total-Tau, Aβ42 Aβ40) cerebrospinal fluid (CSF) patients DLB AD, focusing on prodromal stage. Methods A total 1221 CSF were collected different memory centres (ePLM network) France analysed retrospectively. Samples obtained from (pro-DLB; n=57), (DLB-d; n=154), (pro-AD; n=132)...
The use of cerebrospinal (CSF) biomarkers in the diagnosis Alzheimer's disease (AD) has been gaining interest clinical practice. Although their usefulness demonstrated, potential value older patients remains debated. To assess whether knowledge results CSF AD was associated with same gain diagnostic confidence adults > 80 than younger patients. Prospective multicenter study, including memory clinics physicians who completed a two-part questionnaire for all addressing requirement assessment...
As compared with the long variant (L), short (S) of functional polymorphic region serotonin transporter gene (5-HTTLPR) has been associated a lower antidepressant efficacy in major depression, but some replication studies have evidenced contradictory results. Sex differences may explain these results.One hundred and three inpatients (74 women 29 men) depressive episode were assessed prospectively for after 4 weeks treatment selective reuptake inhibitors (SSRI) non-SSRI drugs.As LL/LS, SS...
Overweight in Guadeloupe is a public health matter affecting children and adults. In the present study we evaluated metabolic profile, including serum ghrelin, leptin adiponectin levels, normal weight, overweight obese school analyzed potential changes anthropometric risk factors after 1-year lifestyle intervention program. Parameters were assessed at baseline 1 year. Three groups (G) defined according International Obesity Task Force reference values, G1: weight / G2: G3: obese. The...
Synaptic degeneration is central in Alzheimer's disease (AD) pathogenesis and biomarkers to monitor this pathophysiology living patients are warranted. We developed a novel sandwich enzyme-linked immunosorbent assay (ELISA) for the measurement of pre-synaptic protein SNAP-25 cerebrospinal fluid (CSF) evaluated it as biomarker AD. CSF samples included pilot study consisting AD (N = 26) controls 26), two independent clinical cohorts controls. Cohort I from with dementia due 17), mild cognitive...
Metabolic dysfunction and dysregulation of leptin signaling have been linked to Alzheimer's disease (AD)'s pathophysiology. The objectives this study were examine the associations between plasma leptin, cerebrospinal fluid (CSF), beta-amyloid (Aβ), tau biomarkers (AT[N] status) with stage cognitive impairment.Cross-sectional analysis data from cognitively impaired patients a tertiary memory clinic. Plasma levels compared according impairment biomarker profiles, using AT(N) classification....
To explore the accuracy of plasma neurofilament light chain (NfL) as a biomarker for diagnosis and staging cognitive impairment, in large cohort with previously diagnosed patients clinical practice.Retrospective, cross-sectional, monocentric study, from tertiary memory clinic. Patients underwent cerebrospinal fluid core Alzheimer's disease (AD) evaluation using ELISA or Elecsys methods, NfL analysis single molecule array technology. The patients' data were examined associations with:...
Abstract Alzheimer's disease (AD) is associated with early metabolic dysfunction and adiponectin, which may play a pathophysiological role. Adiponectin implicated in the regulation of energy homeostasis, carbohydrate, lipid metabolism, as well inflammation modulation. The aim this study was to whether plasma adiponectin levels were different between patients AD confirmed by biomarkers neurological control subjects. We performed monocentric, retrospective, cross‐sectional, observational...
Hyperhomocysteinemia (HHcy) is an established risk factor for cognitive impairment. The specific role of HHcy in the pathophysiology Alzheimer's disease (AD) debated, as most suspected mechanisms overlap with those vascular dementia (VD). aim this study was to explore association between plasma homocysteine (Hcy) levels and cerebrospinal fluid (CSF) biomarkers AD, well brain magnetic resonance imaging (MRI) features. Cross-sectional observational analysis from a single-center tertiary memory...
To elaborate a new algorithm to establish standardized method define cutoffs for CSF biomarkers of Alzheimer disease (AD) by validating the against classification derived from PET imaging.Low and high levels phosphorylated tau were first identified optimal β-amyloid (Aβ) peptide biomarkers. These Aβ then used determine markers. We compared this reference method, based on amyloid imaging status (ADNI study), applied 10 large clinical cohorts patients.A total 6,922 patients with biomarker data...
Hormone therapy increases the risk of venous thromboembolism (VTE) among postmenopausal women. This effect may be modulated by expression cytochromes P450 3A5 (CYP3A5) and 1A2 (CYP1A2) which are involved in hepatic metabolism estrogens.The objective was to investigate impact CYP3A5 CYP1A2 genetic polymorphisms on association VTE with hormone therapy.We conducted a case-control study.This study eight French hospital centers general population.CYP3A5 genotypes were evaluated 195 cases first...