Cecilia Jay
A5046971145- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- Long-Term Effects of COVID-19
- Acute Ischemic Stroke Management
- Radiation Dose and Imaging
- COVID-19 Impact on Reproduction
- MRI in cancer diagnosis
Medawar Building for Pathogen Research
2021-2024
University of Oxford
2021-2024
The extent to which immune responses natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization vaccines protect against variants of concern (VOC) is increasing importance. Accordingly, here we analyse antibodies T cells a recently vaccinated, UK cohort, alongside those recovering from in early 2020. We show that neutralization the VOC compared reference isolate original circulating lineage, B, reduced: more profoundly B.1.351 than for B.1.1.7, or...
Abstract The trajectories of acquired immunity to severe acute respiratory syndrome coronavirus 2 infection are not fully understood. We present a detailed longitudinal cohort study UK healthcare workers prior vaccination, presenting April-June 2020 with asymptomatic or symptomatic infection. Here we show highly variable range responses, some which (T cell interferon-gamma ELISpot, N-specific antibody) wane over time, while others (spike-specific antibody, B memory ELISpot) stable. use...
Introduction The key to understanding the COVID-19 correlates of protection is assessing vaccine-induced immunity in different demographic groups. Young people are at a lower risk mortality, females than males, and often generate stronger immune responses vaccination. Methods We studied two doses BNT162b2 Pfizer vaccine an adolescent cohort (n = 34, ages 12–16), age group previously shown elicit significantly greater same young adults. Adolescents were with aim comparing their response that...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is normally controlled by effective host immunity including innate, humoral and cellular responses. However, the trajectories correlates of acquired immunity, capacity memory responses months after to neutralise variants concern - which has important public health implications not fully understood. To address this, we studied a cohort 78 UK healthcare workers who presented in April June 2020 with symptomatic...
Tools to detect SARS-CoV-2 variants of concern and track the ongoing evolution virus are necessary support public health efforts design evaluation novel COVID-19 therapeutics vaccines. Although next-generation sequencing (NGS) has been adopted as gold standard method for discriminating lineages, alternative methods may be required when processing samples with low viral loads or RNA quality. To this aim, an allele-specific probe PCR (ASP-PCR) targeting lineage-specific single nucleotide...
mRNA vaccine technologies introduced following the SARS-CoV-2 pandemic have highlighted need to better understand interaction of adjuvants and early innate immune response. Type I interferon (IFN-I) is an integral part this response that primes several components adaptive Women are widely reported respond than men tri- quadrivalent influenza vaccines. Plasmacytoid dendritic cells (pDCs) primary cell type responsible for IFN-I production, female pDCs produce more male since upstream pattern...
Introduction Family studies of antiviral immunity provide an opportunity to assess virus-specific in infected and highly exposed individuals, as well examine the dynamics viral infection within families. Transmission SARS-CoV-2 between family members represented a major route for spread during early stages pandemic, due nature transmission through close contacts. Methods Here, humoral cellular is explored 264 infected, or unexposed individuals from 81 families United Kingdom sampled winter...
Abstract Key to understanding COVID-19 correlates of protection is assessing vaccine-induced immunity in different demographic groups. Sex- and age-specific immune differences have a wide impact on outcomes from infections immunisations. Typically, adult females make stronger responses better disease but suffer more adverse events following vaccination are prone autoimmune disease. To understand the mechanisms underlying these vaccine responses, we studied two doses BNT162b2 Pfizer an...
Background: There is no guideline for imaging post endovascular therapy (EVT). MRI considered superior to noncontrast CT assessment of final infarct volume and distinguish contrast from hemorrhage. We sought align the EVT practices with those after intravenous thrombolysis Methods: reviewed EMR records all patients Jan 1, 2019 Dec 31, 2021. assessed quantity within 24h EVT, MRIs performed, indications listed. then undertook an educational program targeting stakeholders. The objective was...
Abstract mRNA vaccine technologies introduced following the SARS-CoV-2 pandemic have highlighted need to better understand interaction of adjuvants and early innate immune response. Interferon type I (IFN-I) is an integral part this response can prime several components adaptive Females are widely reported respond than males seasonal tri- quad-valent influenza vaccines. Plasmacytoid dendritic cells (pDCs) primary cell responsible for IFN-I production female pDCs produce more male since...
Abstract Introduction Tools to detect SARS-Coronavirus-2 variants of concern and track the ongoing evolution virus are necessary support public health efforts design evaluation novel COVID-19 therapeutics vaccines. Although next-generation sequencing (NGS) has been adopted as gold standard method for discriminating SARS-CoV-2 lineages, alternative methods may be required when processing samples with low viral loads or RNA quality. Methods An allele-specific probe polymerase chain reaction...