A5072813566- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Global Maternal and Child Health
- Child Nutrition and Water Access
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Infant Development and Preterm Care
- Infant Nutrition and Health
- Malaria Research and Control
- Prenatal Screening and Diagnostics
- Maternal and Neonatal Healthcare
- Preterm Birth and Chorioamnionitis
- Fetal and Pediatric Neurological Disorders
- Neonatal and fetal brain pathology
- Breastfeeding Practices and Influences
- Mosquito-borne diseases and control
- Assisted Reproductive Technology and Twin Pregnancy
- Obesity, Physical Activity, Diet
- Reproductive Biology and Fertility
- Nutritional Studies and Diet
- Pneumonia and Respiratory Infections
- Ovarian function and disorders
- Blood donation and transfusion practices
- Respiratory viral infections research
- Computational Drug Discovery Methods
London School of Hygiene & Tropical Medicine
2020-2025
J.P. Morgan
2024
Anna Needs Neuroblastoma Answers
2024
University of Oxford
2014-2023
Centre for Policy Dialogue
2023
Statistical Research (United States)
2023
Hospital for Sick Children
2016-2022
SickKids Foundation
2018-2022
Centre for Global Health Research
2022
Nuffield Orthopaedic Centre
2016-2021
BackgroundPreterm birth is the leading cause of neonatal mortality and associated with long-term physical, neurodevelopmental, socioeconomic effects. This study updated national preterm rates trends, plus novel estimates by gestational age subgroups, to inform progress towards global health goals targets, aimed update country, regional, for 2020 in addition trends between 2010 2020.MethodsWe systematically searched population-based, nationally representative data on from Jan 1, 2010, Dec 31,...
BackgroundThe medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality life and mental health are poorly understood.MethodsFifty-eight COVID-19 patients post-hospital discharge 30 age, sex, body mass index comorbidity-matched controls were enrolled for multiorgan (brain, lungs, heart, liver kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary test (CPET), life, cognitive assessments.FindingsAt 2–3...
Charts of size at birth are used to assess the postnatal growth preterm babies on assumption that extrauterine should mimic in uterus.The INTERGROWTH-21(st) Project assessed fetal, newborn, and eight geographically defined populations, which maternal health care nutritional needs were met. From these Fetal Growth Longitudinal Study selected low-risk women starting antenatal before 14 weeks' gestation monitored fetal by ultrasonography. All births from this cohort eligible for Preterm...
Objectives There are no international standards for relating fetal crown–rump length (CRL) to gestational age (GA), and most existing charts have considerable methodological limitations. The INTERGROWTH-21st Project aimed produce the first early size ultrasound dating of pregnancy based on CRL measurement. Methods Urban areas in eight geographically diverse countries that met strict eligibility criteria were selected prospective, population-based recruitment, between 9 + 0 13 6 weeks'...
Introduction The COVID-19 pandemic is disrupting health systems globally. Maternity care disruptions have been surveyed, but not those related to vulnerable small newborns. We aimed survey reported and sick newborn worldwide undertake thematic analysis of healthcare providers’ experiences proposed mitigation strategies. Methods Using a widely disseminated online in three languages, we reached out neonatal providers. collected data on preparedness, effects personnel services, including...
Background Low birthweight (LBW; <2500 g) is an important predictor of health outcomes throughout the life course. We aimed to update country, regional, and global estimates LBW prevalence for 2020, with trends from 2000, assess progress towards targets reduce by 30% 2030. Methods For this systematic analysis, we searched population-based, nationally representative data on Jan 1, Dec 31, 2020. Using 2042 administrative survey datapoints 158 countries areas, developed a Bayesian hierarchical...
Background Severe acute malnutrition (SAM) accounts for two million deaths worldwide annually. In those hospitalised with SAM, concomitant infections and diarrhoea are frequent complications resulting in adverse outcome. We examined the clinical laboratory features on admission outcome of children SAM at a Kenyan district hospital. Methods A 4-year prospective descriptive study involving 1,206 aged 6 months to 12 years, hospitalized managed accordance WHO guidelines. Data features,...
To assess intra- and interobserver variability of fetal biometry measurements throughout pregnancy.A total 175 scans (of 140 fetuses) were prospectively performed at 14-41 weeks gestation ensuring an even distribution gestation. From among three experienced sonographers, a pair observers independently acquired duplicate set seven standard for each fetus. Differences between within expressed in measurement units (mm), as percentage dimensions gestational age-specific Z-scores. For all...
ABSTRACT Objective Accurate gestational‐age (GA) estimation, preferably by ultrasound measurement of fetal crown–rump length before 14 weeks' gestation, is an important component high‐quality antenatal care. The objective this study was to determine how GA can best be estimated for women who present the first time late in pregnancy with uncertain or unknown menstrual dates. Methods INTERGROWTH‐21 st a large, prospective, multicenter, population‐based project performed eight geographically...
<h3>Importance</h3> Preterm birth has been difficult to study and prevent because of its complex syndromic nature. <h3>Objective</h3> To identify phenotypes preterm delivery syndrome in the Newborn Cross-Sectional Study INTERGROWTH-21st Project. <h3>Design, Setting, Participants</h3> A population-based, multiethnic, cross-sectional conducted at 8 geographically demarcated sites Brazil, China, India, Italy, Kenya, Oman, United Kingdom, States. total 60 058 births over a 12-month fixed period...
<b>Objective</b> To describe patterns in maternal gestational weight gain (GWG) healthy pregnancies with good and perinatal outcomes. <b>Design</b> Prospective longitudinal observational study. <b>Setting</b> Eight geographically diverse urban regions Brazil, China, India, Italy, Kenya, Oman, United Kingdom, States, April 2009 to March 2014. <b>Participants</b> Healthy, well nourished, educated women enrolled the Fetal Growth Longitudinal Study component of...
This study aimed to quantify the effect of age, time since last infection, and infection history on rate respiratory syncytial virus age risk disease. A birth cohort 635 children in Kilifi, Kenya, was monitored for infections from January 31, 2002, April 22, 2005. Predictors were examined by Cox regression disease binomial regression. total 598 identified (411 primary, 187 repeat), with 409 determined antigen assay 189 antibody alone (using a “most pragmatic” serologic definition). The...
The ratio of maternal serum sFlt-1 (soluble fms-like tyrosine kinase 1) to PlGF (placental growth factor) has been used retrospectively rule out the occurrence preeclampsia, a pregnancy hypertensive disorder, within 7 days in women presenting with clinical suspicion preeclampsia. A prospective, interventional, parallel-group, randomized trial evaluated use sFlt-1/PlGF suspected Women were assigned reveal (sFlt-1/PlGF result known clinicians) or nonreveal (result unknown) arms. cutoff 38 was...
Myocardial fibrosis as detected by late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) is a powerful prognostic marker in hypertrophic cardiomyopathy (HCM) and may be progressive. The precise mechanisms underlying progression are unclear. We sought to assess the extent of LGE HCM explore potential causal clinical implications.Seventy-two patients had two CMR (CMR1-CMR2) at an interval 5.7 ± 2.8 years with annual follow-up for 6.3 3.6 from CMR1. A combined endpoint heart...
BackgroundWe aimed to describe newborn body composition and identify which anthropometric ratio (weight/length; BMI; or ponderal index, PI) best predicts fat mass (FM) fat-free (FFM).MethodsAir-displacement plethysmography (PEA POD) was used estimate FM, FFM, percentage (BF%). Associations between BF% weight/length, BMI, PI were evaluated in 1,019 newborns using multivariate regression analysis. Charts for generated a prescriptive subsample (n=247). Standards the best-predicting calculated...
Adults born very preterm have increased cardiac mass and reduced function. We investigated whether a hypertrophic phenomenon occurs in later infants when this during early development. Cardiac ultrasound was performed on 392 (33% at mean gestation 34±2 weeks). Scans were fetal development 137, birth 3 months of postnatal age 200, both 55. morphology function quantified computational models created to identify geometric changes. At birth, offspring had volume relative body size with more...
Accurate estimation of gestational age is an essential component good obstetric care and informs clinical decision-making throughout pregnancy. As the date last menstrual period often unknown or uncertain, ultrasound measurement fetal size currently best method for estimating age. The calculation assumes average at each accurate in first trimester, but less so second third trimesters as growth deviates from variation increases. Consequently, late pregnancy has a wide margin error least ±2...