A5008462596- Parkinson's Disease Mechanisms and Treatments
- Statistical Methods in Clinical Trials
- Statistical Methods and Bayesian Inference
- Neurological disorders and treatments
- Optimal Experimental Design Methods
- Acute Ischemic Stroke Management
- Nuclear Receptors and Signaling
- Global Maternal and Child Health
- Gene expression and cancer classification
- Obesity, Physical Activity, Diet
- Bioinformatics and Genomic Networks
- Health Systems, Economic Evaluations, Quality of Life
- Voice and Speech Disorders
- Advanced Statistical Methods and Models
- Child Nutrition and Water Access
- Genetic Associations and Epidemiology
- Dietary Effects on Health
- Meta-analysis and systematic reviews
- Botulinum Toxin and Related Neurological Disorders
- Cerebrovascular and Carotid Artery Diseases
- Statistical Distribution Estimation and Applications
- Obesity and Health Practices
- Bariatric Surgery and Outcomes
- Lysosomal Storage Disorders Research
- Community Development and Social Impact
United Nations Children's Fund
2022-2024
Boston Children's Hospital
2023
University of Iowa
2012-2022
Krembil Research Institute
2020
Toronto Western Hospital
2020
McGill University
2020
Institute on Aging
2017
BioLegend (United States)
2017
Paracelsus Elena Klinik Kassel
2017
Institute for Neurodegenerative Disorders
2017
ABSTRACT Objective: The objective of this study was to assess longitudinal change in clinical and dopamine transporter imaging outcomes early, untreated PD. Methods: We describe 5‐year the MDS‐UPDRS other measures using results from Parkinson's Progression Markers Initiative, a cohort early disease (PD) participants at baseline. also provide data on 123‐I Ioflupane striatal binding correlation between 2 measures. Results: A total 423 PD were recruited, 358 remain year 5. Baseline score 32.4...
Background Low birthweight (LBW; <2500 g) is an important predictor of health outcomes throughout the life course. We aimed to update country, regional, and global estimates LBW prevalence for 2020, with trends from 2000, assess progress towards targets reduce by 30% 2030. Methods For this systematic analysis, we searched population-based, nationally representative data on Jan 1, Dec 31, 2020. Using 2042 administrative survey datapoints 158 countries areas, developed a Bayesian hierarchical...
Accurate prediction of blast loading from accidental hydrogen-air cloud explosion is critical for the planning, design, and operation hydrogen industry. This study proposes an efficient accurate model loads explosions in vented silos. Based on Bayesian regularization data augmentation, artificial neural network (ANN) generated trained with collected computational fluid dynamics (CFD) simulations using FLACS. The influences various parameters including silo dimensions (diameter height),...
Summary This paper brings together some modern statistical methods to address the problem of missing data in obesity trials with repeated measurements. Such occur when subjects miss one or more follow‐up visits, drop out early from an trial. A common approach dealing because dropout is ‘last observation carried forward’ (LOCF). method, although intuitively appealing, requires restrictive assumptions produce valid conclusions. We review need for trials, that must be made regarding such and...
Internal pilot designs involve conducting interim power analysis (without data analysis) to modify the final sample size. Recently developed techniques have been described avoid type~I error rate inflation inherent unadjusted hypothesis tests, while still providing advantages of an internal design. We present GLUMIP 2.0, latest version our free SAS/IML software for planning studies in general linear univariate model (GLUM) framework. The new analytic forms incorporated into updated solve...
Background Inflammation is increasingly recognised as playing a central role in atherosclerosis, and peripheral blood markers of inflammation have been associated with incident recurrent cardiac events. The relationship these potentially modifiable risk to prognosis after ischaemic stroke less clear. Levels Inflammatory Markers the Treatment Stroke (LIMITS) study will address hypotheses related inflammatory secondary prevention an efficient manner using well-established framework Secondary...
Wittes and Brittain recommended using an 'internal pilot study' to adjust sample size. The approach involves five steps in testing a general linear hypothesis for univariate model, with Gaussian errors. First, specify the design, hypothesis, desired test size, power, smallest 'clinically meaningful' effect, speculated error variance. Second, conduct power analysis choose provisionally planned Third, collect specified proportion of as internal sample, estimate variance (but do not...
The diagnosis of Parkinson's disease (PD) is challenging at all stages due to variable symptomatology, comorbidities, and mimicking conditions. Postmortem assessment remains the gold standard for a definitive diagnosis. While it well recognized that PD manifests pathologically in central nervous system with aggregation α-synuclein as Lewy bodies neurites, similar Lewy-type synucleinopathy (LTS) additionally found peripheral may be useful an antemortem biomarker. We have previously detection...
Background Reducing low birthweight (LBW, weight at birth less than 2,500g) prevalence by least 30% between 2012 and 2025 is a target endorsed the World Health Assembly that can contribute to achieving Sustainable Development Goal 2 (Zero Hunger) 2030. The 2019 LBW estimates indicated global of 14.6% (20.5 million newborns) in 2015. We aim develop updated global, regional, national levels for up 202 countries period 2000 2020. Methods Two types sources data will be sought: administrative...
The advent of intra-arterial neurothrombectomy (IAT) for acute ischemic stroke opens a potentially transformative opportunity to improve neuroprotection studies. Combining putative neuroprotectant with recanalization could produce more powerful trials but introduce heterogeneity and adverse event possibilities. We sought demonstrate feasibility IAT in by defining selection criteria an ongoing clinical trial.The study drug, 3K3A-APC, is pleiotropic cytoprotectant may reduce...
<i>Introduction:</i> The excess stroke mortality among African Americans and Southerners is well known. Because a higher proportion of the population living in ‘Stroke Belt’ American, then portion estimated risk death traditionally associated with African-American race may be attributable to geography (i.e., are ‘confounded’). In this paper we estimate that geography. <i>Methods:</i> numbers deaths at county level available from vital statistics system US. A total...
Summary. To compensate for a power analysis based on poor estimate of variance, internal pilot designs use some fraction the planned observations to reestimate error variance and modify final sample size. Ignoring randomness size may bias inflate test We propose evaluate three different tests that control an in general linear univariate model with fixed predictors Gaussian errors. Test 1 uses first plus those guaranteed be collected second estimate. 2 depends mostly 3 unadjusted modifies...
The truncated gamma distribution has been widely studied, primarily in life-testing and reliability settings. Most work assumed an upper bound on the support of random variable, i.e. space is (0, u). We consider a doubly-truncated variable restricted by both lower (l) (u) truncation point, which are considered known. provide simple forms for density, cumulative function (CDF), moment generating function, cumulant characteristic moments. extend results to describe CDF, moments noncentral...
Abstract Although obesity is associated with increased mortality rate and short‐term weight loss improves risk factors for mortality, it has not been convincingly shown that among obese people results in reduced rate. When considering the human literature, pointed out often a sign of illness investigators therefore need to separate intentional from unintentional loss. It generally assumed who state they do intend lose weight, change subsequently observed unintentional. Among such people,...
Abstract Uncertainty surrounding the error covariance matrix often presents biggest barrier to achieving accurate power analysis in ‘univariate’ approach repeated measures of variance (UNIREP). A poor choice gives either an overpowered study which wastes resources, or underpowered with little chance success. Internal pilot designs were introduced resolve such uncertainty about for t‐tests. In earlier papers, we extended use internal pilots any univariate linear model fixed predictors and...