A5026510214- Liver physiology and pathology
- Cancer Cells and Metastasis
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Ubiquitin and proteasome pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- FOXO transcription factor regulation
- Cancer, Hypoxia, and Metabolism
- Liver Disease and Transplantation
- Ferroptosis and cancer prognosis
- Pancreatitis Pathology and Treatment
- MicroRNA in disease regulation
- Cancer-related gene regulation
- RNA modifications and cancer
- Angiogenesis and VEGF in Cancer
- PI3K/AKT/mTOR signaling in cancer
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
Kanazawa University Hospital
2012-2025
Kanazawa University
2015-2025
University of North Carolina at Chapel Hill
2016-2023
Kanazawa Medical University
2015
The hepatitis B virus (HBV) regulatory protein X (HBx) activates gene expression from the HBV covalently closed circular DNA (cccDNA) genome. Interaction of HBx with DDB1-CUL4-ROC1 (CRL4) E3 ligase is critical for this function. Using substrate-trapping proteomics, we identified structural maintenance chromosomes (SMC) complex proteins SMC5 and SMC6 as CRL4(HBx) substrates. infection degraded SMC5/6 in human hepatocytes vitro humanized mice vivo. targets ubiquitylation by subsequent...
Abstract Recent evidence suggests that hepatocellular carcinoma (HCC) is organized by a subset of cells with stem cell features (cancer cells; CSCs). CSCs are considered pivotal target for the eradication cancer, and liver have been identified use various markers. However, little information known about expression patterns characteristics marker-positive CSCs, hampering development personalized CSC-targeted therapy. Here, we show CSC markers EpCAM CD90 independently expressed in cancer. In...
Background/Objectives: Atezolizumab and bevacizumab combination therapy has been established as a standard of care for first-line treatment; however, its efficacy safety have not fully evaluated patients previously treated with systemic therapy. Methods: In this phase II trial, advanced hepatocellular carcinoma lenvatinib were enrolled to receive dose 1,200 mg atezolizumab 15 mg/kg every 3 weeks. The primary endpoint was progression-free survival. secondary endpoints included overall...
The survival of patients with hepatocellular carcinoma (HCC) is often individually different even after surgery for early-stage tumors. Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) has been introduced recently to evaluate hepatic lesions regard vascularity and the activity organic anion transporter OATP1B3. Here we report that Gd-EOB-DTPA-enhanced MRI (EOB-MRI) in combination serum alpha-fetoprotein (AFP) status reflects...
Abstract Recent evidence suggests that a certain type of hepatocellular carcinoma (HCC) is hierarchically organized by subset cells with stem cell features (cancer cells; CSC). Although normal and CSCs are considered to share similar self-renewal programs, it remains unclear whether differentiation programs also maintained in effectively used for tumor eradication. In this study, we investigated the effect oncostatin M (OSM), an interleukin 6–related cytokine known induce hepatoblasts into...
Abstract The behaviors and fates of immune cells in cancer patients, such as dysfunction stem-like states leading to memory formation T cells, are intense focus investigation. Here we show, by post hoc analysis peripheral blood lymphocytes hepatocellular carcinoma patients previously undergoing vaccination with tumour-associated antigen-derived peptides our clinical trials (registration numbers UMIN000003511, UMIN000004540, UMIN000005677, UMIN000003514 UMIN000005678), that induced...
The immuno-pathogenic mechanisms of chronic hepatitis C virus (HCV) infection remain to be elucidated and pose a major hurdle in treating or preventing HCV-induced advanced liver diseases such as cirrhosis. Macrophages are component the inflammatory milieu disease, generally derived from circulating monocytes; however very little is known about their role diseases. To investigate activation macrophages fibrosis, we utilized recently developed humanized mouse model with autologous human...
Since hepatocellular carcinoma (HCC) is a typical hypervascular malignant tumor with poor prognosis, targeting angiogenesis an important therapeutic strategy for advanced HCC. Involvement of bone morphologic protein 9 (BMP9), transforming growth factor-beta superfamily member, has recently been reported in the development liver diseases and angiogenesis. Here, we aimed to elucidate role BMP9 signaling promoting HCC assess antiangiogenic effect BMP receptor inhibitors By analyzing tissue gene...
Backgrounds and Aims Structural dynamics of basement membrane components are still to be elucidated in the process hepatocarcinogenesis. We evaluated characteristics HCC expressing laminin γ2 monomer (LG2m), a component not detected normal tissues, for diagnosis. further determined whether elevated serum LG2m is risk factor development patients with chronic hepatitis C (CHC). Approach Results In cell lines, was expressed alpha‐fetoprotein (AFP)‐negative, CD90‐positive cells characterized by...
Cancer stemness evinces interest owing to the resulting malignancy and poor prognosis. We previously demonstrated that hepatic stem cell-like hepatocellular carcinoma (HpSC-HCC) is associated with high vascular invasion Dickkopf-1 (DKK-1), a Wnt signaling regulator, highly expressed in HpSC-HCC. Here, we assessed diagnostic prognostic potential of serum DKK-1. Its levels were significantly higher 391 patients HCC compared 205 chronic liver disease. Receiver operating characteristic curve...
The hepatitis B virus (HBV) infects many people worldwide. As HBV infection frequently leads to liver fibrosis and carcinogenesis, developing anti-HBV therapeutic drugs is urgent. Therapeutic for preventing covalently closed circular DNA (cccDNA) production, which can eliminate infection, are unavailable. host factor dedicator of cytokinesis 11 (DOCK11) involved in the synthesis maintenance cccDNA
The malignant nature of hepatocellular carcinoma (HCC) is closely related to the presence cancer stem cells (CSCs). Bone morphologic protein 9 (BMP9), a member transforming growth factor-beta (TGF-β) superfamily, was recently reported be involved in liver diseases including cancer. We aimed elucidate role BMP9 signaling HCC-CSC properties and assess therapeutic effect BMP receptor inhibitors HCC. have identified that high expression tumor tissues or serum from patients with HCC leads poorer...
Whether or not pancreaticobiliary maljunction (PBM) is a risk factor for pancreatic cancer (PC) unclear. We present case of metachronous PC with PBM diagnosed after cholecystectomy gallbladder cancer, in which follow-up imaging was possible until onset. A 63-year-old man who had been and undergone 5 years earlier developed pancreatitis. Pancreatography revealed PBM, duct brush cytology adenocarcinoma. On reviewing the images, morphological abnormalities, observed before cholecystectomy, were...
The identification of effective diagnostic and prognostic biomarkers is critical to improving the outcomes patients with pancreatic ductal adenocarcinoma (PDAC). We explored potential serum levels laminin γ2 monomer (LG2m) as a biomarker in PDAC. This study included two cohorts. Cohort 1 142 PDAC patients, 55 intraductal papillary mucinous neoplasm (IPMN), 46 healthy individuals. 2 518 patients. medical records were reviewed. Cut-off for LG2m determined by receiver operating characteristic...
Abstract Aim This study aimed to evaluate the impact of revised deceased donor liver transplantation (DDLT) criteria on hepatocellular carcinoma (HCC) patients newly eligible under Child–Pugh classification B (CP‐B), by focusing prognosis and risk HCC recurrence beyond Japan while waiting list. Methods A retrospective analysis was carried out 1155 diagnosed with at Kanazawa University Hospital between 2006 2021. Prognosis were analyzed for DDLT criteria. Results Of patients, 57 (4.9%)...
Mint3 enhances aerobic ATP production with subsequent nuclear translocation of hypoxia-inducible factor-1 (HIF-1) and activation angiogenesis-related genes. It remains unclear if when is activated whether it involved in hepatocarcinogenesis. We explored the expression surgically resected hepatocellular carcinoma (HCC) tissues. evaluated effects knockdown on spheroid formation capacity subcutaneous tumor growth immune-deficient mice. used knockout mice to evaluate chemically induced HCC...
Photodynamic therapy (PDT) with talaporfin sodium shows promise as a salvage treatment for locoregional recurrence of esophageal cancer after chemoradiotherapy (CRT). However, its application in cervical is limited due to anatomical challenges, such the restricted maneuverability standard endoscopes and difficulty achieving stable perpendicular laser irradiation. This study introduces modified PDT technique using thin endoscope customized attachment lesion stabilization precise targeting....
Combination therapy with lenvatinib and hepatic arterial infusion chemotherapy (HAIC) using cisplatin had a high antitumor effect for advanced hepatocellular carcinoma (HCC); however, the efficacy of adding HAIC to remains unclear. We retrospectively reviewed charts HCC patients who were treated or plus compared between them. The received 12 mg 8 once daily by weight in both groups, 65 mg/m2 through artery every 4 weeks group. A total 140 included this analysis, 40 each group groups selected...
Sorafenib is a multiple receptor tyrosine kinase inhibitor known to prolong overall survival in patients with advanced hepatocellular carcinoma (HCC). Predicting this drug's benefits challenging because clinical responses are rarely measurable during treatment. In study, we hypothesized that serum cytokines levels could predict the of HCC patients, as sorafenib targets signaling pathways activated tumor stromal microenvironment and potentially affects cytokine profiles.Of 143 advanced-stage...
Cancer stem cells (CSCs) are a pivotal target for eradicating hepatocellular carcinoma (HCC). We previously reported that distinctive CSCs regulating tumorigenicity (EpCAM+ CSCs) and metastasis (CD90+ have different epithelial/mesenchymal gene expression signatures. Here, we examined the influence of sorafenib, multiple-receptor tyrosine kinase inhibitor used as first-line treatment advanced HCC, on EpCAM+ CD90+ CSCs. showed higher c-Kit gene/protein than cells. Sorafenib reduced number with...
Osteopontin (OPN) is involved in cell proliferation, migration, inflammation, and tumor progression various tissues. OPN induces stemness by interacting with CD44, but the functional relevance of OPN-mediated interferon (IFN) signaling hepatitis C virus (HCV) replication stem populations remains unclear. In this study, we investigated effect on HCV IFN cancer cells (CSCs) positive for epithelial adhesion molecule (EpCAM) CD44. We show that EpCAM+/CD44+ CSCs marked when compared to...