A5083631538- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Pancreatitis Pathology and Treatment
- Mitochondrial Function and Pathology
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- IgG4-Related and Inflammatory Diseases
- Genetics, Aging, and Longevity in Model Organisms
- Iron Metabolism and Disorders
- Esophageal Cancer Research and Treatment
- Gallbladder and Bile Duct Disorders
- Neuroendocrine Tumor Research Advances
- Glycosylation and Glycoproteins Research
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Gastrointestinal Tumor Research and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Ocular Surface and Contact Lens
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Neuroblastoma Research and Treatments
- MicroRNA in disease regulation
- Galectins and Cancer Biology
Kanazawa University Hospital
2015-2025
Kanazawa University
2016-2025
Tokai University
2013-2023
Kanazawa Hospital
2020-2022
Municipal Tsuruga Hospital
2021
Kanazawa Medical Center
2016-2018
National Hospital Organization
2016-2018
North Carolina State University
2014-2018
Keiju Medical Center
2017-2018
Matsumoto Livestock Hygiene Service Center
2017
Oxidative damage and inflammation are proposed to be involved in an age-related functional decline of exocrine glands. However, the molecular mechanism how oxidative stress affects secretory function glands is unclear. We developed a novel mev-1 conditional transgenic mouse model (Tet-mev-1) using modified tetracycline system (Tet-On/Off system). This demonstrated decreased tear production with morphological changes including leukocytic infiltration fibrosis. found that gene encodes Cyt-1,...
Summary Background Idiopathic mesenteric phlebosclerosis (IMP) is a rare disease, characterised by thickening of the wall right hemicolon with calcification veins. However, aetiology remains unknown. Aim To investigate possible association herbal medicines IMP. Method The clinical data four our own patients were collected. Furthermore, we searched for previous reports about similar detailed descriptions prescriptions that they had taken. We compared ingredients to identify toxic agent as...
Adipose tissue stromal cells contain a substantial number of mesenchymal stem cells. As such, their application to regeneration miscellaneous impaired organs has attracted much attention. We designed clinical study investigate freshly isolated autologous adipose tissue-derived stromal/stem (regenerative) cell (ADRC) therapy for liver cirrhosis and conducted treatment in four cirrhotic patients. ADRCs were from subcutaneous obtained by the liposuction method, followed with use Celution system...
The etiology of astrocyte dysfunction is not well understood even though neuronal defects have been extensively studied in a variety degenerative diseases. Astrocyte could be triggered by the oxidative stress that occurs during physiological aging. Here, we provide evidence intracellular or mitochondrial reactive oxygen species (ROS) at levels can cause hippocampal (neuronal) dysfunctions. Specifically, demonstrate occur area middle-aged Tet-mev-1 mice with SDHCV69E mutation. These are...
Historical data in the 1950s suggests that 7%, 11%, 33%, and 87% of couples were infertile by ages 30, 35, 40 45, respectively. Up to 22.3% have unexplained infertility. Oxidative stress is associated with male female However, there insufficient evidence relating influence oxidative on maintenance a viable pregnancy, including pregnancy complications fetal development. Recently, we established Tet-mev-1 conditional transgenic mice, which can express doxycycline-induced mutant SDHCV69E...
Malignant tumors usually involve a relatively hypoxic state, which induces overexpression of hypoxia‐inducible factor‐1α (HIF‐1α) to satisfactorily enable the tumor survive. Thus, inhibition mammalian target rapamycin (mTOR) pathway including HIF‐1α is expected play major role in suppression cell growth, having recently drawn much attention as an anti‐cancer therapeutic strategy for various malignant tumors. In present study, compared clear adenocarcinoma (CLA) ovary with serous (SEA),...
Histone deacetylase (HDAC) inhibitor is known to have a cytotoxic effect on ovarian cancer cell lines. The present study analyzed the association between immunohistochemical HDAC expression and clinicopathological findings, in particular, with histological type of chemotherapy. histology 201 cancers addressed was as follows: Serous carcinoma (SEC), 100 cases; clear (CCC), 56 endometrioid (EMC), 36 mucinous (MUC), 9 cases. Immunohistochemical analyses HDACs 1, 2, 3, 4, 5, 6 7 levels were...
Recently, a new disease entity termed gastric adenocarcinoma of fundic gland type (GA-FG) was proposed. We treated five cases GA-FG with endoscopic submucosal dissection. All tumors were small and located in the upper third stomach. Four macroscopically identified as 0-IIa one 0-IIb. Narrow-band imaging magnifying endoscopy showed an irregular microvascular pattern 2 regular remainder. arose from deep layer lamina propria mucosae invasion. Lymphatic invasion seen only case, while no venous...
Intracellular iron is tightly regulated by coordinated expression of transport and storage genes, such as transferrin receptor-1 (TfR1) ferritin. They are primarily through iron-induced dissociation iron-regulatory proteins (IRPs) from iron-responsive elements (IREs) in the 3′-UTR (untranslated region) TfR1 or 5′-UTR ferritin mRNA, resulting destabilization mRNA release translation block. Thus high decreases via degradation increases translational up-regulation. However, molecular mechanism...
The mammalian Shc family, composed of p46, p52, and p66 isoforms, serves as an adaptor protein in cell growth stress response. p66Shc was shown to be a negative lifespan regulator by acting prooxidant mitochondria; however, the regulatory mechanisms expression function are incompletely understood. This study provides evidence for new features serving antioxidant critical differentiation. Unique among transcription is activated through response element (ARE)–nuclear factor erythroid 2–related...
Relapse and diabetes mellitus (DM) are major problems for the prognosis of autoimmune pancreatitis (AIP). We examined type 1 AIP after corticosteroid therapy (CST)-induced remission in terms relapse DM.The study enrolled 82 patients diagnosed with who achieved CST. retrospectively evaluated rate administration period CST, clinical factors associated relapse, temporal change glucose tolerance.During follow-up, 32 (39.0%) experienced relapse. There was no significant factor that could predict...
Abstract Ovarian clear cell carcinoma (OCCC) is associated with a frequent loss in ARID1A function. reportedly suppresses histone deacetylase (HDAC)6 OCCC directly. Here, we evaluated the clinical significance of HDAC6 expression and its related factors terms status. Immunohistochemical HDAC6, hypoxia inducible factors-1α (HIF-1α), programmed death-1 ligand (PD-L1), CD44 (cancer stem marker), was analysed for 106 patients. High nuclear correlated patient death ( p = 0.038). In multivariate...
Whether or not pancreaticobiliary maljunction (PBM) is a risk factor for pancreatic cancer (PC) unclear. We present case of metachronous PC with PBM diagnosed after cholecystectomy gallbladder cancer, in which follow-up imaging was possible until onset. A 63-year-old man who had been and undergone 5 years earlier developed pancreatitis. Pancreatography revealed PBM, duct brush cytology adenocarcinoma. On reviewing the images, morphological abnormalities, observed before cholecystectomy, were...
The identification of effective diagnostic and prognostic biomarkers is critical to improving the outcomes patients with pancreatic ductal adenocarcinoma (PDAC). We explored potential serum levels laminin γ2 monomer (LG2m) as a biomarker in PDAC. This study included two cohorts. Cohort 1 142 PDAC patients, 55 intraductal papillary mucinous neoplasm (IPMN), 46 healthy individuals. 2 518 patients. medical records were reviewed. Cut-off for LG2m determined by receiver operating characteristic...
The usefulness of endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) for biliary obstruction has been widely reported in cases where a transpapillary approach is unsuitable or impossible [1] [2]. Covered self-expandable metal stents (CSEMSs) are often used EUS-HGS, and the presence cover provides peace mind that bile leakage will not occur, even if CSEMS passes through abdominal cavity [3]; however, we report here case which, despite successful EUS-HGS using CSEMS, peritonitis...