A5040197823- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Salivary Gland Disorders and Functions
- Glaucoma and retinal disorders
- Allergic Rhinitis and Sensitization
- Proteoglycans and glycosaminoglycans research
- Ocular Infections and Treatments
- Olfactory and Sensory Function Studies
- Advanced Glycation End Products research
- Skin Protection and Aging
- Ion Channels and Receptors
- Complement system in diseases
- Glycosylation and Glycoproteins Research
- Dermatology and Skin Diseases
- Circadian rhythm and melatonin
- Intraocular Surgery and Lenses
- Nasolacrimal Duct Obstruction Treatments
- Biochemical effects in animals
- Fibroblast Growth Factor Research
- Immune Response and Inflammation
- melanin and skin pigmentation
- Glutathione Transferases and Polymorphisms
- Medical and Biological Ozone Research
- Retinal and Macular Surgery
National Heart Lung and Blood Institute
2024-2025
Kitasato University
2017-2025
Kitasato Institute Hospital
2017-2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2015-2024
Keio University
2010-2021
Eunice Kennedy Shriver Center
2019
Office of Extramural Research
2019
MedStar Washington Hospital Center
2015-2016
Ministry of Education, Culture, Sports, Science and Technology
2012-2015
National Maternity Hospital
2015
Salivary gland hypofunction, also known as xerostomia, occurs a result of radiation therapy for head cancer, Sjögren's syndrome or aging, and can cause variety critical oral health issues, including dental decay, bacterial infection, mastication dysfunction, swallowing dysfunction reduced quality life. Here we demonstrate the full functional regeneration salivary that reproduces morphogenesis induced by reciprocal epithelial mesenchymal interactions through orthotopic transplantation...
Oxidative damage and inflammation are proposed to be involved in an age-related functional decline of exocrine glands. However, the molecular mechanism how oxidative stress affects secretory function glands is unclear. We developed a novel mev-1 conditional transgenic mouse model (Tet-mev-1) using modified tetracycline system (Tet-On/Off system). This demonstrated decreased tear production with morphological changes including leukocytic infiltration fibrosis. found that gene encodes Cyt-1,...
In certain epithelial tissues, activation of transient receptor potential (TRP) vanilloid subtype 1 (TRPV1) by noxious stimuli induces pro-inflammatory cytokine release, which helps to mitigate the challenge. While corneal epithelium elicits such responses a variety challenges, it remains unknown whether TRPV1 mediates secretion. Accordingly, we probed for expression and function in human (HCEC) rabbit cell (RCEC) lines, their primary counterparts, mouse situ. Cell membrane perinuclear was...
To investigate whether beta-catenin activation and epithelial-mesenchymal transition (EMT) is involved in the pathogenesis of pterygium.beta-Catenin E-cadherin expression were examined surgically excised tissue eye bank corneas with intact pterygium. Snail Slug, transcriptional repressors E-cadherin, matrix metalloproteinase (MMP)-7, a down-stream gene regulated by also investigated. Epithelial cells undergoing EMT-like changes identified double immunostaining for alpha-smooth muscle actin...
Chronic graft-versus-host disease (cGVHD), a serious complication following allogeneic HSCT (hematopoietic stem cell transplantation), is characterized by systemic fibrosis. The tissue renin-angiotensin system (RAS) involved in the fibrotic pathogenesis, and an angiotensin II type 1 receptor (AT1R) antagonist can attenuate Tissue RAS present lacrimal gland, lung, liver, known to be pathogenesis of lung liver. This study aimed determine whether gland assess effect AT1R on preventing liver...
The ocular surface is always attacked by oxidative stress, and cornea epithelial cells are supposed to have their own recovery system against stress. Therefore we hypothesized that tears supply key molecules for preventing stress in cornea. potential target molecule focused selenoprotein P (SeP). SeP a carrier of selenium, which an essential trace element many animals, metabolism the organism, was extremely expressed lacrimal gland. An experiment performed with eye drops rat dry model,...
Purpose.: To investigate the efficacy of 2% rebamipide ophthalmic solution on tear functions and ocular surface status superoxide dismutase-1(Sod1−/− ) mice. Methods.: Two percent Rebamipide was applied to 40-week-old male Sod1−/− wild-type (WT) mice four times a day for 2 weeks. We examined cytokine concentrations in fluid (by CytoBead assay), film break-up time, amount production, expressions mucins 1, 4, 5AC, by RT-PCR. also performed vital staining surface, PAS muc5AC,...
The purpose of this study was to evaluate the efficacy fish oil supplementation added usual dry eye treatment in subjects a randomized controlled trial. Twenty-seven typical were selected from 43 candidates by diagnostic criterion for study. They assigned group (n = 15) or placebo 12). Fish ingested capsules containing eicosapentaenoic acid (EPA, 1245 mg/day) and docosahexaenoic (DHA, 540 12 weeks. Placebo without EPA DHA. A visual analog scale test estimating subjective symptoms, Schirmer I...
Background Peripheral nerve damage of the cornea is a complication following surgery or infection which may lead to decreased visual function. We examined efficacy semaphorin 3A inhibitor, SM-345431, in promoting regeneration peripheral nerves mouse corneal transplantation model. Methodology/Principal Findings P0-Cre/Floxed-EGFP mice express EGFP cells were used as recipients with syngeneic wild-type donors. SM-345431 was administered subconjunctivally every 2 days while control received...
Purpose: To evaluate the efficacy and safety of new moist cool air device (MCAD) for ocular symptoms, tear film stability surface status in office workers with dry eye disease (DED). Methods: In this prospective single-centre clinical trial, 40 eyes 20 patients DED were recruited randomly divided into two groups (group MCAD exposure group without MCAD). All subjects are visual display terminals (VDTs) spending at least 4 h/day front VDTs. Patients using underwent applications a total five...
The morbidity of ocular diseases, including macular degeneration, diabetic retinopathy, and dry eye disease, has been gradually increasing worldwide. Because these diseases develop from age-associated dysfunctions, interventions against the aging process itself may be a promising strategy for their management. Among several approaches to interrupt processes, calorie restriction (CR) shown recover and/or slow age-related functional declines in various organs, eye. Here, we review as potential...
Purpose Two new drugs with mucin-inducing and secretion-promotive effects, rebamipide diquafosol, were recently approved as topical dry-eye treatments. We report two cases in which the long-term use of eye drops improved chronic ocular graft-versus-host disease (cGVHD)–related dry cicatricial pemphigoid (OCP)-like disease. Case Reports 1. A 61-year-old woman had cGVHD-related that resisted traditional medications. Next, we diquafosol addition to conventional The patient used for 6 months...