A5102758025- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Ocular Diseases and Behçet’s Syndrome
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Chronic Lymphocytic Leukemia Research
- Corneal surgery and disorders
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Eosinophilic Disorders and Syndromes
- Platelet Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Systemic Lupus Erythematosus Research
- Blood groups and transfusion
- Ophthalmology and Visual Impairment Studies
- Corneal Surgery and Treatments
- Microbial metabolism and enzyme function
- Blood disorders and treatments
St Mary's Hospital
2010-2025
Teikyo University
2016-2025
Kitasato University
2025
St. Mary’s Hospital
2007-2025
Teikyo University Hospital
2018
Kitasato Institute Hospital
2018
Dokkyo Medical University Saitama Medical Center
2015
Iwate Medical University
2015
Manhattan Eye, Ear and Throat Hospital
2009-2014
Osaka City University
2014
In Brief Purpose: The purpose of the study was to evaluate choroidal thickness in patients with central serous chorioretinopathy, a disease attributed increased vascular hyperpermeability. Methods: Patients chorioretinopathy underwent enhanced depth imaging spectral-domain optical coherence tomography, which obtained by positioning tomography device close enough eye acquire an inverted image. Seven sections, each comprising 100 averaged scans, were within 5° × 30° rectangle encompass macula....
Oxidative stress has long been linked to the pathogenesis of neurodegenerative diseases; however, whether it is a cause or merely consequence degenerative process still unknown. We show that mice deficient in Cu, Zn-superoxide dismutase (SOD1) have features typical age-related macular degeneration humans. Investigations senescent Sod1(-/-) different ages showed older animals had drusen, thickened Bruch's membrane, and choroidal neovascularization. The number drusen increased with age,...
In Brief Purpose: To examine predictive factors for visual acuity in highly myopic eyes. Methods: Consecutive patients with high myopia (≥6 diopters [D]) no other pathology such as lacquer cracks the fovea, choroidal neovascularization, or macular schisis, were evaluated. The study was performed 2 retina centers, one United States and Japan. Enhanced depth imaging optical coherence tomography obtained, central foveal, outer retinal hyporeflective layer inner segment to pigment epithelium...
In Brief Purpose: To investigate the effects of phosphodiesterase-5 inhibitor, sildenafil citrate, on choroidal thickness using eye-tracked enhanced depth imaging spectral-domain optical coherence tomography. Methods: a prospective interventional study, 8 healthy subjects (4 men and 4 women) with no ocular history underwent tomography at baseline, 1 hour, 3 hours after ingestion 100 mg citrate. Choroidal measurements for both eyes were taken by 2 masked readers 1-hour, 3-hour time points....
Lutein has been the focus of recent study as a possible therapeutic approach for retinal diseases, but molecular mechanism its neuroprotective effect remains to be elucidated. The aim this was investigate, with use mouse endotoxin-induced uveitis (EIU) model, effects lutein against neural damage caused by inflammation.EIU induced intraperitoneal injection lipopolysaccharide (LPS). Each animal given subcutaneous or vehicle three times: concurrently and 3 hours before after LPS injection....
Upshaw-Schulman syndrome (USS) is a congenital thrombotic thrombocytopenic purpura (TTP) due to mutations in the gene that encodes for ADAMTS13 (ADAMTS13), but its clinical signs may be mild or absent during childhood. We have identified 37 patients with USS (24 females, 13 males) belonging 32 families. The nine women from six families who were diagnosed their first pregnancy are focus of this report. Six had episodes thrombocytopenia childhood misdiagnosed as idiopathic purpura....
OBJECTIVE—Pathogenic mechanisms underlying diabetes-induced retinal dysfunction are not fully understood. The aim of the present study was to show relationship renin-angiotensin system (RAS) with synaptic vesicle protein synaptophysin and neuronal activity in diabetic retina. RESEARCH DESIGN AND METHODS—C57BL/6 mice streptozotocin-induced diabetes were treated angiotensin II type 1 receptor (AT1R) blocker telimsartan or valsartan, function analyzed by electroretinography. Retinal production...
In Brief Purpose: To describe simultaneous scanning laser ophthalmoscope indocyanine green angiographic and eye-tracked spectral-domain optical coherence tomography findings in eyes with polypoidal choroidal vasculopathy (PCV). Methods: Eighteen of 18 patients PCV because a variety different diagnoses were imaged angiography to localize the polyps their associated vascular structures respect retinal layers. Results: Regardless underlying diagnosis, imaging localized within larger Type 1...
The purpose of this study was to characterize retinal manifestations optic pit maculopathy using high-resolution optical coherence tomography.Consecutive patients with maculopathy, diagnosed by their typical appearance ophthalmoscopy, were imaged color fundus photography and tomography. location characteristics any fluid within under the retina determined.The mean age 16 (7 women) 35.9 years (standard deviation: 18.5 years). visual acuity ranged from 20/20 20/1000 (median, 20/200). Retinal...
The purpose of this study was to investigate the fundus autofluorescence and optical coherence tomography findings in eyes with acute zonal occult outer retinopathy (AZOOR).A retrospective observational case series spectral domain a patients AZOOR.There were 19 11 (10 women), who had mean age 49.1 +/- 13.9 years. Fundus abnormalities seen 17 eyes, more common peripapillary area, smaller extent than abnormalities. Nine showed progression hypoautofluorescence area during follow-up 69.7 months....
We evaluated the usefulness of prognostic markers in patients with diffuse large B‐cell lymphoma (DLBCL) treated cyclophosphamide, vincristine, doxorubicin, and prednisolone (CHOP) ± rituximab (R‐CHOP) Japan. studied 730 DLBCL; 451 received CHOP 279 R‐CHOP. analyzed biopsy samples immunohistochemically for germinal center B cells (CD10, Bcl‐6), postgerminal (Multiple myeloma‐1), apoptosis (Bcl‐2). The median follow‐up period surviving was 56.4 months group 25.2 R‐CHOP group. DLBCL were...
To investigate spectral domain optical coherence tomography and autofluorescence findings in eyes with pseudoxanthoma elasticum.A retrospective analysis of visual acuity, tomography, consecutive patients elasticum was performed. The evaluated for retinal architecture, subretinal accumulations, photoreceptor layer thickness. Autofluorescence near-infrared reflectance images were reviewed correlative findings.There 21 (42 eyes) a mean age 56.1 ± 12.4 years. Subretinal fluid found 14 eyes, 7...
Abstract We have studied Ags recognized by HLA class I-restricted CTLs established from tumor site to better understand the molecular basis of immunology. HLA-A24-restricted and tumor-specific T cells infiltrating into lung adenocarcinoma two antigenic peptides encoded a cyclophilin B gene, family genes for cyclophilins involved in cell activation. These at positions 84–92 91–99 induced CTL activity against PBMCs leukemia patients, but not epithelial cancer patients or healthy donors. In...