A5079904432- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- COVID-19 diagnosis using AI
- Diabetes and associated disorders
- Family and Disability Support Research
- Metabolomics and Mass Spectrometry Studies
- Animal Nutrition and Physiology
- Myasthenia Gravis and Thymoma
- Viral gastroenteritis research and epidemiology
- Isotope Analysis in Ecology
- COVID-19 and healthcare impacts
- Bacillus and Francisella bacterial research
- Childhood Cancer Survivors' Quality of Life
- Autism Spectrum Disorder Research
- Immune responses and vaccinations
- Animal Behavior and Welfare Studies
- Poxvirus research and outbreaks
- COVID-19 epidemiological studies
- Animal testing and alternatives
- Chronic Obstructive Pulmonary Disease (COPD) Research
National Center for Global Health and Medicine
2020-2024
National Institute of Infectious Diseases
2022
Segawa Neurological Clinic for Children
2001
Saitama Cancer Center
1979-1991
There is limited understanding of the characteristics patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan.
To determine virus shedding duration, we examined clinical samples collected from the upper respiratory tracts of persons infected with severe acute syndrome coronavirus 2 Omicron variant in Japan during November 29-December 18, 2021. Vaccinees mild or asymptomatic infection shed infectious 6-9 days after onset diagnosis, even symptom resolution.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing disease 2019 (COVID-19) was announced as an outbreak by World Health Organization (WHO) in January 2020 and a pandemic March 2020. The majority of infected individuals have experienced no or only mild symptoms, ranging from fully asymptomatic cases to pneumonic disease. However, minority develop severe symptoms. objective this study identify susceptible HLA alleles clinical markers that can be used risk...
Before widespread coronavirus disease (COVID-19) vaccinations, Japan experienced three COVID-19 epidemic waves. This study aimed to evaluate the characteristics of hospitalised patients and reveal temporal changes.
Infectious virus shedding from individuals infected with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is used to estimate human-to-human transmission risk. Control of SARS-CoV-2 requires identifying the immune correlates that protect infectious shedding. Mucosal immunity prevents infection by SARS-CoV-2, which replicates in epithelium and spreads rapidly other hosts. However, whether mucosal SARS-CoV-2-infected unknown. We examined relationship between viral RNA dynamics,...
The global outbreak of mpox in 2022 and subsequent sporadic outbreaks 2023 highlighted the importance nonpharmaceutical interventions such as case isolation. Individual variations viral shedding dynamics may lead to either premature ending isolation for infectious individuals, or unnecessarily prolonged those who are no longer infectious. Here, we developed a modeling framework characterize heterogeneous infectiousness profiles – specifically, when infected individuals cease be based on load...
ObjectivesRapid antigen testing (RAT) for coronavirus disease 2019 (COVID-19) has lower sensitivity but high accuracy during the early stage when compared to reverse transcription quantitative polymerase chain reaction (RT-qPCR). The aim of this study was investigate concordance between RAT and RT-qPCR results, their prediction transmission.MethodsThis single-center retrospective observational inpatients with COVID-19 conducted from March 6 June 14, 2020. Nasopharyngeal swabs were used...
The outbreak of COVID-19 caused by infection with SARS-CoV-2 virus has become a worldwide pandemic, and the number patients presenting respiratory failure is rapidly increasing in Japan. An international meta-analysis been conducted to identify genetic factors associated onset severity COVID-19, but these have yet be fully clarified. Here, we carried out genomic analysis based on genome-wide association study (GWAS) Japanese determine whether reported or meta-GWAS are replicated population,...
IntroductionThe automated quantitative antigen test (QAT), which detects severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is suitable for mass screening. However, its diagnostic capability differentiated by time from onset and potential contribution to infectivity assessment have not been fully investigated.MethodsA retrospective, observational study using nasopharyngeal swab specimens disease (COVID-19) inpatients was conducted LumipulseⓇ SARS-CoV-2 test. Diagnostic accuracy...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing disease 2019 (COVID-19) was announced as an outbreak by World Health Organization (WHO) in January 2020 and a pandemic March 2020. The majority of infected individuals have experienced no or only mild symptoms, ranging from fully asymptomatic cases to pneumonic disease. However, minority develop severe symptoms. objective this study identify susceptible HLA alleles clinical markers for early...
Restriction fragment length polymorphisms of rat mitochondrial DNA (mtDNA) were examined using various kinds laboratory strains in Japan. The results show that mtDNA rats, Rattus norvegicus, are highly polymorphic; at least 7 types, Aa, Ba, Bb, Cb, Dc, Eb, and Fa, found with the use 6 restri-ction enzymes, EcoR I, Hind II, Hha Hpa Taq Hinf I. Types Eb distributed widely several strains, whereas types Dc Fa limited to some specific strains. These indicate restriction can be applied genetic monitoring
To clarify whether the determining effect of thymic lymphoma susceptible‐1 (Tls‐1) gene is on putative N‐propyl‐N‐nitrosourea (PNU) target cells among T‐lineage or other host factors, we investigated PNU‐induced lymphomagenesis in transplantation chimeras between susceptible F344 and resistant LES strain rats. Administration PNU to lethally irradiated (F344 X LES)F1 rats reconstituted with bone marrow from either parental invariably led development donor‐origin lymphomas. On hand, lymphomas...
Although biomarkers to predict coronavirus disease 2019 (COVID-19) severity have been studied since the early pandemic, no clear guidelines on using them in clinical practice are available. Here, we examined ability of four conserved sera from COVID-19 patients who received inpatient care between January 1, 2020 and September 21, 2021 at National Center for Global Health Medicine, collected appropriate time prediction. We predicted illness two situations: 1) prediction future oxygen...
The detection of other pathogens in patients with hospitalized coronavirus disease (COVID-19) are not frequent. Considering that data from Japan limited, we conducted an observational study including COVID-19 at the National Center for Global Health and Medicine January to September 2020. In total, 247 were included study. Rapid diagnostic tests, such as immunochromatography, performed 31 (12.6%). Film Array Respiratory Panel was 18 (7.3%) patients, none tests positive than severe acute...
Rearing and breeding scores were compared between groups of mice (JCL : ICR ddN strains) raised with two different types automatic water-supply systems; the Japanese type American type, using manual system as control. The superior in body weight gain to those systems. As survival rate, however, m; anual gave better results than type. weanling rate test, somewhat result either types. Accidental water leaks, which are serious problems systems, occurred frequently only when was used. Only one...