A5056341876- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Use and Resistance
- COVID-19 and healthcare impacts
- Inflammatory Bowel Disease
- Congenital Heart Disease Studies
- Viral Infections and Outbreaks Research
- Veterinary Equine Medical Research
- Microscopic Colitis
- Sepsis Diagnosis and Treatment
- Viral Infections and Vectors
- COVID-19 and Mental Health
- Muscle metabolism and nutrition
- Hepatitis C virus research
- COVID-19 Impact on Reproduction
- Mechanical Circulatory Support Devices
- Respiratory viral infections research
- Disaster Response and Management
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Cardiac, Anesthesia and Surgical Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Respiratory Support and Mechanisms
Teine Keijinkai Hospital
2024-2025
National Center for Global Health and Medicine
2019-2025
Hamamatsu University School of Medicine
2021-2025
Hokkaido University
2016-2024
Center for Global Health
2021-2024
Sapporo City University
2024
Kobe University
2023-2024
Weatherford College
2024
National Center for Geriatrics and Gerontology
2022
Iwata City Hospital
2021
There is limited understanding of the characteristics patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan.
The scientific community is focused on developing antiviral therapies to mitigate the impacts of ongoing novel coronavirus disease 2019 (COVID-19) outbreak. This will be facilitated by improved understanding viral dynamics within infected hosts. Here, using a mathematical model in combination with published load data, we compare within-host SARS-CoV-2 analogous MERS-CoV and SARS-CoV. Our quantitative analyses revealed that reproduction number at symptom onset was statistically significantly...
Objectives To investigate the risk factors contributing to severity on admission. Additionally, of worst and fatality were studied. Moreover, compared based three points: early severity, fatality. Design An observational cohort study using data entered in a Japan nationwide COVID-19 inpatient registry, COVIREGI-JP. Setting As 28 September 2020, 10480 cases from 802 facilities have been registered. Participating cover wide range hospitals where patients with are admitted Japan. Participants...
Before widespread coronavirus disease (COVID-19) vaccinations, Japan experienced three COVID-19 epidemic waves. This study aimed to evaluate the characteristics of hospitalised patients and reveal temporal changes.
Lassa fever (LF) is a zoonotic disease that widespread in West Africa and involves animal-to-human human-to-human transmission. Animal-to-human transmission occurs upon exposure to rodent excreta secretions, i.e. urine saliva, via the bodily fluids of an infected person. To elucidate seasonal drivers LF epidemics, we employed mathematical model analyse datasets human infection, population dynamics climatological variations capture underlying dynamics. The surveillance-based incidence data...
Background Development of an effective antiviral drug for Coronavirus Disease 2019 (COVID-19) is a global health priority. Although several candidate drugs have been identified through in vitro and vivo models, consistent compelling evidence from clinical studies limited. The lack trials may stem part the imperfect design trials. We investigated how antivirals need to be designed, especially focusing on sample size randomized controlled Methods findings A modeling study was conducted help...
<b><i>Introduction:</i></b> Old age is an independent risk factor (RF) for severe COVID-19; evidence clinico-epidemiological characteristics among elderly COVID-19 patients scarce. We aimed to analyze clinical and epidemiological comorbidities associated with inpatients in age-stratified populations of cohort. <b><i>Methods:</i></b> conducted a retrospective cohort study, using nationwide registry data hospitalized before October 31, 2020...
The scientific community is focussed on developing antiviral therapies to mitigate the impacts of ongoing novel coronavirus disease (COVID-19) outbreak. This will be facilitated by improved understanding viral dynamics within infected hosts. Here, using a mathematical model in combination with published load data collected from same specimen (throat / nasal swabs or nasopharyngeal sputum tracheal aspirate), we compare within-host for patients current outbreak analogous MERS-CoV and SARS-CoV...
Delta variant of concern (VOC) is the current predominant severe acute respiratory coronavirus type 2 strain causing disease 2019 (COVID-19); however, information regarding impact VOC on clinical features and outcomes in pediatric patients with COVID-19 limited. We conducted a retrospective observational study using data <18 years age COVIREGI-JP, registry Japan. The were divided into two groups according to timing enrollment (pre-Delta era, October 2020 May 2021; August 2021),...
BackgroundAntibody testing can easily evaluate the clinical status of patients, aid in diagnosis multisystem inflammatory syndrome, and monitor immunity level population. However, applicability serological tests detecting antibodies against severe acute respiratory syndrome 2 (SARS-CoV-2) spike-binding protein remains limited. This study aimed to quantify both serum-derived neutralizing immunoglobulin-G (IgG) antibody activity amount anti-SARS-CoV-2 Spike-IgG (S-IgG) convalescent...
A large epidemic of cholera, caused by Vibrio cholerae, serotype Ogawa, has been ongoing in Yemen, 2017. To improve the situation awareness, present study aimed to forecast cholera epidemic, explicitly addressing reporting delay and ascertainment bias. Using weekly incidence suspected cases, updated as a revised curve every week, was incorporated into estimation model. case fatality risk calculated World Health Organization, bias adjusted, enabling us parameterize family logistic curves...
Social contact surveys can greatly help in quantifying the heterogeneous patterns of infectious disease transmission. The present study aimed to conduct a survey Japan, offering estimates by age and location validating social matrix using seroepidemiological dataset influenza.An internet-based questionnaire was conducted, covering all 47 prefectures Japan including total 1476 households. quantified assuming reciprocity maximum likelihood method. By imposing several parametric assumptions for...
Abstract In early 2020, Japan repatriated 566 nationals from China. Universal laboratory testing and 14-day monitoring of returnees detected 12 cases severe acute respiratory syndrome coronavirus 2 infection; initial screening results were negative for 5. Common outcomes remaining asymptomatic (n = 4) pneumonia 6). Overall, performed poorly.
Abstract Objective To evaluate the efficacy and safety of direct hemoperfusion using a polymyxin B‐immobilized polystyrene column (PMX‐DHP) in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐positive pneumonia patients. Methods This study was case series conducted at designated infectious diseases hospital. Twelve SARS‐CoV‐2‐positive patients with partial pressure arterial oxygen/percentage inspired oxygen (P/F) ratio < 300 were treated PMX‐DHP on two consecutive days each...
Among patients with coronavirus disease 2019 (COVID-19), the factors that affect anti-severe acute respiratory syndrome 2 (SARS-CoV-2) antibody production remain unclear. This study aimed to identify such among convalescing from COVID-19.This comprised who had been diagnosed COVID-19 between January 1 and June 30, 2020 gave consent for anti-SARS-CoV-2 spike protein measurement using enzyme-linked immunosorbent assay during their and/or convalescent phases. Factors related elevated titers...
Abstract Background The large number of antibiotic prescriptions for non-bacterial upper respiratory infections has been reported globally. reduction unnecessary use is critical. Elucidating geographical factors associated with using nationwide data may guide national policy regarding stewardship. Methods This study evaluated patients sole diagnosis health insurance claims across all Japanese prefectures. A multivariable negative binomial regression analysis was implemented the outcome...
Carbapenem-resistant Gram-negative bacilli (CRGNB), especially Enterobacterales, Pseudomonas aeruginosa and Acinetobacter baumannii, are critical pathogens associated with excess morbidity mortality. To elucidate their molecular epidemiology clinical outcomes in Japan, patients CRGNB were enrolled the MDR organisms research network (MDRnet) consisting of eight tertiary care facilities. Between 2019 2022, 246 unique carbapenem-resistant Enterobacterales (CRE), P. (CRPA) A. baumannii (CRAB)...
Horse kicks are a rare cause of injury and tend to severe complications such as visceral organ injury. Traumatic duodenal injuries associated with high mortality rates. Furthermore, their reconstructive procedures vary widely require appropriate on-the-spot judgment by the surgeon. We experienced case blunt abdominal trauma complete transection first portion duodenum caused horse kick without any lesions. A good postoperative course was achieved trimming pyloric part stomach performing an...
The interaction between the Niemann-Pick C1 (NPC1) protein and glycoprotein (GP) of filoviruses is essential for viral entry into host cells. Single nucleotide polymorphisms (SNPs) in NPC1, which lead to amino acid substitutions, can significantly alter efficiency. However, quantitative impact these SNPs remains unclear. To address this, we investigate vitro cell-to-cell infection using a plaque assay with vesicular stomatitis virus (VSV) expressing Ebola Marburg GP. We employ an agent-based...