A5038009551- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Muscle activation and electromyography studies
- Superconducting Materials and Applications
- Trauma and Emergency Care Studies
- Genetic Neurodegenerative Diseases
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Stroke Rehabilitation and Recovery
- HVDC Systems and Fault Protection
- Neuroscience and Neural Engineering
- Emergency and Acute Care Studies
- Cardiovascular Function and Risk Factors
- Infectious Encephalopathies and Encephalitis
- Cardiac Arrest and Resuscitation
- Physics of Superconductivity and Magnetism
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- RNA regulation and disease
- Botulinum Toxin and Related Neurological Disorders
- Amyotrophic Lateral Sclerosis Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Genetics and Neurodevelopmental Disorders
Gifu University
2016-2025
National Center for Global Health and Medicine
2015-2024
Center for Global Health
2010-2024
Japan Association for Development of Community Medicine
2007-2024
Gifu University Hospital
2006-2022
Juntendo University
2020
Keio University
2007-2016
GlaxoSmithKline (India)
2015
Jichi Medical University
2014
Osaka Prefectural Institute of Public Health
1992-2013
Recent studies have shown that scalp electroencephalogram (EEG) based brain-computer interface (BCI) has a great potential for motor rehabilitation in stroke patients with severe hemiplegia. However, key elements BCI architecture functional recovery yet to be clear. We this study focused on the type of feedback patients, which is given contingently their motor-related EEG context. The efficacy visual and somatosensory feedbacks was compared by two-group chronic who are suffering All were...
Amyotrophic lateral sclerosis (ALS) is a rare disease involving selective and progressive degeneration disappearance of motor neurons. Oxidative stress believed to contribute its pathogenesis. We have investigated the efficacy safety edaravone, free radical scavenger previously approved for treatment acute cerebral infarction, in ALS patients. Within an open trial design, 20 subjects with received either 30 mg (5 subjects) or 60 (15 edaravone via intravenous drip once per day. Two weeks...
The reliability of ultrasonographic detection (US) hemoperitoneum in blunt abdominal trauma was evaluated a prospective study 72 patients. Independent the examiner, sensitivity, specificity, and accuracy were, respectively, 86.7%, 100%, 97.2%. Laparotomy indicated 76.9% US hemoperitoneum-positive cases. No negative laparotomies were performed this group. If is revealed vital signs are unstable, we think laparotomy indicated. We believe that an emergency center quick, safe screening method...
A new method for the evaluation of stroke patients, designated Stroke Impairment Assessment Set (SIAS) is presented. The SIAS primarily employs single-task assessment various functions and rates performance on scales 0 to 5 or 3. items evaluated include motor function, muscle tone, sensation, range motion, pain, trunk control, visuospatial perception, aphasia unaffected side. Scores each item are plotted a radar chart, so that deficits can be identified at glance. inter-observer variation in...
To explore the effectiveness of neurorehabilitative training using an electroencephalogram-based brain- computer interface for hand paralysis following stroke.A case series study.Eight outpatients with chronic stroke demonstrating moderate to severe hemiparesis.Based on analysis volitionally decreased amplitudes sensory motor rhythm during imagery involving extending affected fingers, real-time visual feedback was provided. After successful imagery, a mechanical orthosis partially extended...
To clarify the influence of moderate hypothermia on production proinflammatory cytokines.Controlled in vitro study.Research laboratory.Peripheral blood mononuclear cells from healthy adult human subjects.Stimulation with 1 microg/mL lipopolysaccharide at 33 degrees C and 37 C.Concentrations released tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 were measured chronologically by enzyme immunoassay. The number mRNA copies these cytokines was determined competitive reverse...
Abstract Background The mu event-related desynchronization (ERD) is supposed to reflect motor preparation and appear during imagery. aim of this study examine the modulation ERD with transcranial direct current stimulation (tDCS). Methods Six healthy subjects were asked imagine their right hand grasping something after receiving a visual cue. Electroencephalograms (EEGs) recorded near left M1. rhythm (mu ERD) by imagery was measured. tDCS (10 min, 1 mA) used modulate cortical excitability...
Brain computer interface technology is of great interest to researchers as a potential therapeutic measure for people with severe neurological disorders. The aim this study was examine the efficacy brain interface, by comparing conventional neuromuscular electrical stimulation and interface-driven stimulation, using an A-B-A-B withdrawal single-subject design.A 38-year-old male hemiplegia due putaminal haemorrhage participated in study. design involved 2 epochs. In epoch A, patient attempted...
Anti-IgLON5 disease is a rare and likely underdiagnosed subtype of autoimmune encephalitis. The displays heterogeneous phenotype that includes sleep, movement bulbar-associated dysfunction. presence IgLON5-antibodies in CSF/serum, together with strong association HLA-DRB1*10:01∼DQB1*05:01, supports an basis. In this study, multicentric human leukocyte antigen (HLA) study 87 anti-IgLON5 patients revealed stronger HLA-DQ than HLA-DR. Specifically, we identified predisposing rank-wise...
Our analysis of chromosomal aberrations in primary gastric cancers using comparative genomic hybridization has revealed novel, high and frequent copy number increases the long arm chromosome 20, indicating that this region contains novel amplified genes involved cancer progression. AIB1, a member steroid receptor co-activator-1 family, been cloned on 20q12 as candidate target gene for amplification human breast cancers. In study, we examined numbers AIB1 copies well their expression relation...
OBJECTIVE To assess vital signs, QT intervals, and newly diagnosed cardiovascular disease during severe hypoglycemia in diabetic patients. RESEARCH DESIGN AND METHODS From January 2006 to March 2012, we conducted a retrospective cohort study type 1 2 patients with at national center Japan. Severe was defined as the presence of any hypoglycemic symptoms that could not be resolved by themselves prehospital settings. RESULTS A total 59,602 cases visited emergency room ambulance were screened,...
Whole-body computed tomography (WBCT) has become commonly used in the management of blunt trauma (BT) high-income countries, but its indications are controversial. Advanced life support recommends conducting head CT for traumatized patients with a Glasgow Coma Scale (GCS) score 3 to 12. This nationwide study was conducted verify that WBCT is also beneficial these patients.The Japan Trauma Data Bank (2007-2010) identify BT systolic blood pressure greater than 75 mm Hg having GCS Because...
Background Whether rapid transportation can benefit patients with trauma remains controversial. We determined the association between prehospital time and outcome to explore concept of "golden hour" for injured patients. Methods findings conducted a retrospective cohort study transported from scene hospitals by emergency medical service (EMS) January 1, 2016, November 30, 2018, using data Pan-Asia Trauma Outcomes Study (PATOS) database. Prehospital intervals were categorized into response...
The F wave represents only a small percentage of the motoneuron pool invaded antidromically by any single impulse. We studied 22 median nerves from 11 healthy subjects to determine whether recurrent discharges are preferentially generated in select group motoneurons with certain physiologic characteristics. Partial excitation nerve elicited no consistent bias toward either lower or higher threshold motor fibers. When fast conducting axons were progressively blocked using collision technique,...
Oscillatory activity of the sensorimotor cortex shows coherence with muscle within 15- to 35-Hz frequency band (β-band) during weak moderate sustained isometric contraction. We aimed examine acute changes in this corticomuscular coupling due fatigue and its effect on steadiness exerted force. quantified between electroencephalogram (EEG) recorded over rectified surface electromyogram (EMG) tibialis anterior as well coefficient variance dorsiflexion force (Force(CV)) sum auto-power spectral...
Oscillatory activity of the sensorimotor cortex has been reported to show coherence with muscle in 15- 35-Hz frequency band (β-band) during weak moderate intensity isometric contraction. The present study examined variance magnitude corticomuscular across a large number subjects. We quantified between EEG over and rectified electromyogram (EMG) from tibialis anterior tonic contraction at 30% maximal effort 100 healthy young individuals. estimated peak EEG-EMG (Cohmax) ratio sum autopower...
The shock index (SI), defined as heart rate (HR) divided by systolic blood pressure (SBP), is reported to be a more sensitive marker of than traditional vital signs alone. In previous literature, use the reverse (rSI), taken SBP HR, recommended instead SI for hospital triage. Among traumatized patients aged > 55 years, multiplied age (SIA) might provide better prediction early post-injury mortality. Separately, Glasgow Coma Scale (GCS) score has been shown very strong predictor. When...