A5102708233- Genetic factors in colorectal cancer
- Cholinesterase and Neurodegenerative Diseases
- Colorectal Cancer Treatments and Studies
- Dementia and Cognitive Impairment Research
- Medical Imaging Techniques and Applications
- Nutrition and Health in Aging
- Body Composition Measurement Techniques
- Physical Activity and Health
- Alzheimer's disease research and treatments
- Intracranial Aneurysms: Treatment and Complications
- Gastric Cancer Management and Outcomes
- Anesthesia and Pain Management
- Muscle metabolism and nutrition
- Muscle activation and electromyography studies
- Obesity, Physical Activity, Diet
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Computational Drug Discovery Methods
- Blood Pressure and Hypertension Studies
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Vascular Malformations Diagnosis and Treatment
- Diet and metabolism studies
Juntendo University Shizuoka Hospital
2024-2025
Izumi City General Hospital
2014-2025
Yokogawa Electric (Japan)
2025
Nagoya University
2015-2024
Tokyo Metropolitan Institute of Gerontology
2008-2024
Osaka Electro-Communication University
2007-2024
Fukushima Medical University Hospital
2024
Shinshu University
2024
Tokyo Metropolitan Geriatric Hospital
2008-2023
NSABP Foundation
2011-2023
Aim To examine the relationship between calf circumference and muscle mass, to evaluate suitability of as a surrogate marker mass for diagnosis sarcopenia among middle‐aged older J apanese men women. Methods A total 526 adults aged 40–89 years participated in present cross‐sectional study. The maximum was measured standing position. Appendicular skeletal using dual‐energy X ‐ray absorptiometry, index calculated appendicular divided by square height (kg/m 2 ). cut‐off values were defined less...
Abstract Purpose: Host immune response to tumor may be an important prognostic factor for colon cancer patients. However, little is known on significance of histopathologic lymphoid reaction tumor, independent the number lymph nodes examined and tumoral molecular alterations, including microsatellite instability (MSI) CpG island methylator phenotype (CIMP), both which are associated with lymphocytic clinical outcome. Experimental Design: Using 843 colorectal patients in two prospective...
We have reported that the ambient gyrus is site with greatest accumulation of argyrophilic grains (AGs) and degeneration responsible for dementia grains. Here we analyzed 1,405 serial autopsy cases from 2 hospitals detected AGs only in older than 56 years age. The distribution followed a stereotypic regional pattern. Thus, propose following staging paradigm: stage I: restricted to its vicinity; II: more apparent anterior posterior medial temporal lobe, including pole, as well subiculum...
<b>Objective:</b> To characterize brain cholinergic deficits in Parkinson disease (PD), PD with dementia (PDD), and Lewy bodies (DLB). <b>Methods:</b> Participants included 18 patients PD, 21 PDD/DLB, 26 healthy controls. The group consisted of nine early each a duration less than 3 years, five whom were de novo patients, advanced greater or equal to years. PDD/DLB 10 PDD 11 DLB. All subjects underwent PET scans <i>N</i>-[<sup>11</sup>C]-methyl-4-piperidyl acetate measure...
The purpose of this study was to examine the prognostic and oxaliplatin predictive value mismatch repair (MMR) status common hot spot mutations, which we previously identified in stage II III colon cancer.Mutations BRAF, KRAS, NRAS, MET, PIK3CA were profiled 2,299 tumors from National Surgical Adjuvant Breast Bowel Project (NSABP) clinical trials C-07 (n = 1,836) C-08 463) with Type Plex chemistry mass spectrometry. tested worth adding 5-fluorouracil plus leucovorin, bevacizumab FOLFOX. Cox...
Abstract Purpose: STAT3 is a transcription factor that constitutively activated in some cancers. It seems to play crucial roles cell proliferation and survival, angiogenesis, tumor-promoting inflammation, suppression of antitumor host immune response the tumor microenvironment. Although signaling pathway potential drug target, clinical, pathologic, molecular, or prognostic features STAT3-activated colorectal cancer remain uncertain. Experimental Design: Utilizing database 724 colon rectal...
Abstract Background Genome-wide DNA hypomethylation plays a role in genomic instability and carcinogenesis. LINE-1 (L1 retrotransposon) constitutes substantial portion of the human genome, methylation correlates with global status. colon cancer has been strongly associated poor prognosis. However, whether hypomethylators constitute distinct subtype remains uncertain. Recent evidence for concordant within synchronous colorectal pairs suggests presence non-stochastic mechanism influencing...
Background: Cause of death (COD) information taken from certificates is often inaccurate and incomplete. However, the accuracy Underlying CODs (UCODs) recorded on has not been comprehensively described when multiple diseases are present.Methods: A total 450 consecutive autopsies performed at a geriatric hospital in Japan between February 2000 August 2002 were studied. We evaluated concordance rate, sensitivity, specificity major UCODs (cancer, heart disease, pneumonia) reported compared with...
National Surgical Adjuvant Breast and Bowel Project (NSABP) trial B-31 suggested the efficacy of adjuvant trastuzumab, even in HER2-negative breast cancer. This finding prompted us to develop a predictive model for degree benefit from trastuzumab using archived tumor blocks B-31.Case subjects with were randomly divided into discovery (n = 588) confirmation cohorts 991). A was built cohort through gene expression profiling 462 genes nCounter assay. predefined cut point tested cohort....
We measured brain acetylcholinesterase activity in 30 patients with Alzheimer's disease (AD) and 14 age-matched controls by positron emission tomography (PET) using a carbon 11-labeled acetylcholine analogue. Seven AD had repeat PET scans. The k3 values were calculated as an index of three-compartment analysis the metabolite corrected arterial input function. Twenty-eight (14 each early late onset subgroups) retained study so to equalize range average severity cognitive impairment within...
To determine whether radiographic images after radiofrequency (RF)-induced coagulation necrosis are correlated with the pathologic effects, we evaluated morphology and histologic characteristics of RF ablation lesions over a 6-month follow-up period compared results those radiologic studies. Thirty-three hepatocellular carcinoma (HCC) tumors maximum diameter 3 cm or less were treated percutaneously by using in 26 patients. Six resected 4 weeks ablation; remaining 27 underwent biopsy...
We investigated the incidence and extent of Lewy body (LB)-related α-synucleinopathy (LBAS) in olfactory bulb (OB) 320 consecutive autopsy patients from a general geriatric hospital (mean age, 81.5 ± 8.5 years). Paraffin sections were immunostained with anti-phosphorylated α-synuclein, tyrosine hydroxylase, phosphorylated tau, amyloid β antibodies. LBAS was found 102 (31.9%) central nervous system, including spinal cord; OB involved 85 (26.6%). Among these patients, 2 had only anterior...
The newly proposed 15- and 24-loci mycobacterial interspersed repetitive unit (MIRU)-variable-number tandem repeat (VNTR) typing method was evaluated for its ability to differentiate 181 Mycobacterium tuberculosis Beijing family strains. Compared with the original 12-loci MIRU-VNTR method, 15-loci system dramatically improved discriminatory power strains; however, large clusters that could be further differentiated by IS6110 restriction fragment length polymorphism (RFLP) were still...
Whole-body computed tomography (WBCT) has become commonly used in the management of blunt trauma (BT) high-income countries, but its indications are controversial. Advanced life support recommends conducting head CT for traumatized patients with a Glasgow Coma Scale (GCS) score 3 to 12. This nationwide study was conducted verify that WBCT is also beneficial these patients.The Japan Trauma Data Bank (2007-2010) identify BT systolic blood pressure greater than 75 mm Hg having GCS Because...
To investigate the effect of long-term tenofovir disoproxil fumarate (TDF) use on renal function, especially in patients with low body weight who are vulnerable to TDF nephrotoxicity.A single-center, observational study Tokyo, Japan.We performed a 10 years cohort 792 HIV-1-infected patients. The estimated glomerular filtration rate (eGFR) was investigated treatment-naive started TDF-containing antiretroviral therapy (n = 422) and those abacavir-containing as control 370). Three endpoints...
123I-meta-iodobenzyl-guanidine (123I-MIBG) myocardial scintigraphy is used as a diagnostic imaging test to differentiate Lewy body diseases (LBDs), including Parkinson disease and dementia with bodies, from other similar diseases. However, this lacks validation of its accuracy against the gold standard. Our aim was validate 123I-MIBG for LBD autopsy, standard.This retrospective, cross-sectional study included consecutive autopsy patients Brain Bank Aging Research who had undergone...
Acetylcholinesterase (AChE) activities in the brain of three patients with AD were measured once before and during donepezil treatment (5 mg/d two patients, 3 one patient) using PET N-[11C]methylpiperidin-4-yl acetate. Donepezil reduced k(3) values, an index AChE activity, cerebral cortex by 39 +/- 5%. All showed some degree symptomatic improvement, it was concluded that this improvement likely caused improved cholinergic activity inhibition brain.
Corticobasal syndrome, progressive supranuclear palsy and frontotemporal dementia are all part of a disease spectrum that includes common cognitive impairment movement disorders. The aim this study was to characterize brain cholinergic deficits in these We measured acetylcholinesterase activity by [11C] N-methylpiperidin-4-yl acetate positron emission tomography seven patients with corticobasal syndrome (67.6 ± 5.9 years), 12 (68.5 4.1 eight (59.8 6.9 years) 16 healthy controls (61.2 8.5...
The aim of this study was to investigate whether amyloid deposition is associated with Alzheimer's disease (AD)‐like cortical atrophy in Lewy body (LB) (LBD). Participants included 15 LBD dementia patients (8 bodies [DLB] and 7 Parkinson's [PD] [PDD]), 13 AD patients, 17 healthy controls. Age, gender, Mini–Mental State Examination scores were matched between patient groups. All subjects underwent PET scans [ 11 C]Pittsburgh Compound B measure brain as well three‐dimensional T1‐weighted MRI....
National Surgical Adjuvant Breast and Bowel Project protocol C-08 tested the worth of adding 1 year bevacizumab to oxaliplatin-based standard adjuvant chemotherapy regimen in treatment stage II/III colon cancer. Although overall result was negative, possibility that a molecularly defined subset could benefit from cannot be ruled out. We performed post hoc Cox regression analyses test for marker-by-treatment interactions pathological features survival using Kaplan–Meier method. All...