A5085134523- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS drug development and treatment
- Infectious Diseases and Tuberculosis
- COVID-19 Impact on Reproduction
- Pneumonia and Respiratory Infections
- Diagnosis and treatment of tuberculosis
- SARS-CoV-2 detection and testing
- Influenza Virus Research Studies
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- Infectious Diseases and Mycology
- Prenatal Screening and Diagnostics
- Reproductive System and Pregnancy
- Respiratory viral infections research
- Biosensors and Analytical Detection
- Biosimilars and Bioanalytical Methods
- Pregnancy and Medication Impact
- Autoimmune and Inflammatory Disorders
- Virology and Viral Diseases
- Long-Term Effects of COVID-19
- Data-Driven Disease Surveillance
Statens Serum Institut
2010-2022
Amager Hospital
2021-2022
Copenhagen University Hospital
2013-2022
Hvidovre Hospital
2001-2022
Engineering Service Center und Handel (Germany)
2021
Nordsjællands Hospital
2021
Community Link
2020
University of Copenhagen
2001-2020
Statistics Denmark
2020
Novo Nordisk Foundation
2020
Drug-resistant Mycobacterium tuberculosis is challenging elimination of (TB). We evaluated risk factors for TB and levels second-line drug resistance in M. patients Europe with multidrug-resistant (MDR) TB. A total 380 MDR 376 non-MDR were enrolled at 23 centers 16 countries during 2010-2011. 52.4% had never been treated TB, which suggests primary transmission tuberculosis. At initiation treatment 59.7% strains tested resistant to pyrazinamide, 51.1% ≥1 drug, 26.6% injectable drugs, 17.6%...
Does maternal infection with severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) in first trimester pregnancy have an impact on the fetal development as measured by nuchal translucency thickness and loss?Nuchal at scan was not significantly different pregnant women versus without SARS-CoV-2 early there no increased risk of loss trimester.Pregnant are more vulnerable to viral infections. Previous coronavirus epidemics been associated morbidity, mortality adverse obstetric outcomes....
ABSTRACT Tuberculosis patients may harbor both drug-susceptible and -resistant bacteria, i.e., heteroresistance. We used mixtures of rifampin-resistant -susceptible Mycobacterium tuberculosis strains to simulate heteroresistance in patient samples. Molecular tests can be for earlier discovery multidrug resistance (MDR), but the sensitivity detect is unknown. Conventional phenotypic drug susceptibility testing was most sensitive, whereas two line probe assays sequencing were unable clinically...
We sought to compare the effectiveness of two World Health Organization (WHO)-recommended regimens for treatment rifampin- or multidrug-resistant (RR/MDR) tuberculosis (TB): a standardised regimen 9–12 months (the “shorter regimen”) and individualised ≥20 (“longer regimens”). collected individual patient data from observational studies identified through systematic reviews public call data. included patients meeting WHO eligibility criteria shorter regimen: not previously treated with...
OBJECTIVE: To investigate the frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in parturient women, their partners, and newborns association such with obstetric neonatal outcomes. METHODS: From April 4 to July 3, 2020, a single university hospital Denmark, all women partners were invited participate study, along newborns. Participating had pharyngeal swab blood sample taken at admission; immediately after delivery, was drawn from umbilical cord. The swabs...
This is an exciting time for tuberculosis (TB) diagnostics. The technology rapid diagnosis of TB and rifampicin (RMP) resistance in pulmonary sputum smear-positive specimens well advanced, assays have high specificity with good sensitivity. Nevertheless, the current sensitivity detection means that these still cannot replace standard diagnostic methods or conventional drug susceptibility testing (DST). In extra-pulmonary specimens, performance molecular tools varies should be considered...
ABSTRACT Patients may harbor both drug-susceptible and -resistant bacteria, representing heteroresistance. We studied mixtures of isoniazid-resistant -susceptible Mycobacterium tuberculosis strains. Conventional drug susceptibility testing was the most sensitive method detection, whereas line probe assay sequencing were not able to detect clinically relevant 1% proportion resistant bacteria.
ABSTRACT Since the late 1980s several studies have described increased incidence and severity of invasive group A streptococcal (GAS) infections. However, most on GAS pathogenesis focused information obtained during outbreaks. We analyzed isolate distribution host susceptibility as part a nationwide prospective surveillance study performed between January 2001 August 2002. isolates collected from 201 patients with infections, 335 noninvasive 17 asymptomatic carriers were characterized...
ABSTRACT A multiplex PCR DNA strip assay (Genotype MTBDR) designed to detect rifampin ( rpoB ) and high-level isoniazid katG resistance mutations in Mycobacterium tuberculosis isolates was optimized for clinical specimens. Successful genotypic results were achieved with 36 of 38 (95%) smear-positive respiratory specimens, allowing rapid therapeutic adjustments transmittable drug-resistant tuberculosis.
A yellow-pigmented, scotochromogenic, slowly growing mycobacterial strain, designated T1921T, was isolated from the disseminated osteomyelitic lesions of a 7-year-old child with an underlying partial gamma interferon receptor alpha-1 deficiency. Hybridization by line probe assay indicated presence Mycobacterium species. Sequencing 16S rRNA gene, internally transcribed spacer (ITS) region and hsp65 rpoB genes revealed that strain T1921T could be differentiated all recognized species genus...
In Denmark, tetracycline resistance in Streptococcus pyogenes is frequent (>30%) whereas macrolide low (<5%). The aim of this study was to investigate the genetic background tetracycline- and macrolide-resistant S. (MRSP) correlation between use using international data. A total 133 MRSP isolates were received at Statens Serum Institut from nine Danish clinical microbiology laboratories between. November 2000, 2002. macrolide-resistance genes, erm(B), erm(A), mef(A) detected 46%, 18%, 32%...
<i>Background/Aims:</i> Sweet’s syndrome (SS) is a severe dermatosis that may be an extraintestinal manifestation of inflammatory bowel disease (IBD). Worldwide, 35 cases SS associated with IBD have been reported. We present the first case severe, recurrent in combination amebic infection and ulcerative colitis complicated multiple other manifestations. <i>Methods:</i> Disease course was monitored by serum YKL-40 C-reactive protein (CRP), white blood cell count,...
Rationale: Until 2020, extensively drug-resistant tuberculosis (XDR-TB) was defined as TB with resistance to rifampicin and isoniazid (multidrug-resistant [MDR-TB]), any fluoroquinolone (FQ), second-line injectable drug (SLID). In 2019, the World Health Organization issued new recommendations for treating patients TB, substantially limiting role of SLIDs in MDR-TB treatment thus putting definition XDR-TB into question. Objectives: To propose an up-to-date XDR-TB. Methods: We used a large...
Multidrug-resistant tuberculosis (MDR-TB) is a major burden to public health in Europe. Reported treatment success rates are around 50% or less, and cure even lower.To document the management outcome patients with MDR-TB Europe.We performed prospective cohort study, analyzing outcomes stratified by incidence of Treatment were compared World Health Organization alternative simplified definitions Tuberculosis Network European Trialsgroup (TBNET).A total 380 recruited followed up between 2010...
The aim of the present study was to evaluate a new improved multiplex polymerase chain reaction (PCR) hybridisation assay detect multidrug-resistant tuberculosis. assay, developed rifampin (rpoB) and isoniazid (katG) gene mutations causing Mycobacterium tuberculosis resistance, recently extended include inhA that code for low-level resistance. Interpretable results were obtained in 115 isolates all smear-positive clinical specimens. Rifampin resistance correctly identified specimens 20 21...
Point-of-care (POC) quantification of antibody responses against SARS-CoV-2 spike protein can enable decentralized monitoring immune after infection or vaccination. We evaluated a novel POC microfluidic cartridge-based device (ViroTrack Sero COVID-19 Total Ab) for quantitative detection total antibodies trimeric compared to standard laboratory chemiluminescence (CLIA)-based tests. Antibody 101 individuals were measured on capillary blood, venous whole plasma, and diluted plasma samples...