A5015460829- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Pneumonia and Respiratory Infections
- Neonatal and Maternal Infections
- Respiratory viral infections research
- Otolaryngology and Infectious Diseases
- Bacterial Infections and Vaccines
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Identification and Susceptibility Testing
- Emergency and Acute Care Studies
- Gallbladder and Bile Duct Disorders
- Influenza Virus Research Studies
- Infective Endocarditis Diagnosis and Management
- Kawasaki Disease and Coronary Complications
- Evolution and Genetic Dynamics
- Tropical and Extratropical Cyclones Research
- Meteorological Phenomena and Simulations
- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Microbial infections and disease research
- Antibiotics Pharmacokinetics and Efficacy
- Climate variability and models
Public Health Agency of Sweden
2014-2022
Swedish Institute
2004-2013
Karolinska Institutet
2003-2009
Psychiatry Baselland
2009
University of California, San Diego
2009
Umeå University
2009
Uppsala University
2009
Karolinska University Hospital
2003-2007
The efficacy and safety of high-dose intravenous polyspecific immunoglobulin G (IVIG) as adjunctive therapy in streptococcal toxic shock syndrome (STSS) were evaluated a multicenter, randomized, double-blind, placebo-controlled trial. trial was prematurely terminated because slow patient recruitment, results obtained from 21 enrolled patients (10 IVIG recipients 11 placebo recipients). primary end point mortality at 28 days, 3.6-fold higher rate found the group. A significant decrease...
ABSTRACT The past 2 decades have brought worrying increases in severe Streptococcus pyogenes diseases globally. To investigate and compare the epidemiological patterns of these within Europe, data were collected through a European Union FP-5-funded program (Strep-EURO). Prospective population-based surveillance S. infection diagnosed during 2003 2004 was undertaken 11 countries across Europe (Cyprus, Czech Republic, Denmark, Finland, France, Germany, Greece, Italy, Romania, Sweden, United...
ABSTRACT In an attempt to compare the epidemiology of severe Streptococcus pyogenes infection within Europe, prospective data were collected through Strep-EURO program. Surveillance for cases S. diagnosed during 2003 and 2004 was undertaken in 11 countries across Europe by using a standardized case definition questionnaire. Patient as well bacterial isolates characterized T M/ emm typing, selected strains analyzed presence superantigen genes. Data clinical microbiological patterns infections...
Significance Epidemics of microbial infections are a considerable threat to human and animal health. Analysis 3,615 genome sequences, coupled with virulence studies in animals, permitted us delineate the nature timing molecular events that contributed an ongoing global epidemic caused by group A Streptococcus , “flesh-eating” pathogen. We clarified decades-long uncertainty about sequence genomic alterations underpinned epidemic. Analyses this type crucial for developing better strategies...
This study provides evidence for intravenous immunoglobulin as a safe adjunctive therapy that contributes to improved survival in streptococcal toxic shock syndrome. In addition, this gives further clinical support the use of clindamycin these patients. Background. Streptococcal syndrome (STSS) and necrotizing fasciitis are 2 most severe invasive manifestations caused by group A Streptococcus (GAS). Intravenous (IVIG) has been suggested treatment with beneficial effect on mortality. However...
The incidence and severity of invasive group A streptococcal infection demonstrate great variability over time, which at least, in part, seems to be related type distribution among the human population.An enhanced surveillance study (746 isolates) was performed Sweden from April 2002 through December 2004. Noninvasive isolates either throat or skin (773 were collected parallel for comparison. Clinical epidemiological data obtained 88% patients with disease isolate characteristics, including...
The effects of pneumococcal conjugated vaccines (PCVs) need to be investigated. In Stockholm County, Sweden, PCV7 was introduced in the childhood immunisation programme 2007 and changed PCV13 2010. Over 90% all invasive isolates during 2005–2014 (n=2336) carriage isolates, 260 before 647 after vaccine introduction, were characterised by serotyping, molecular typing antibiotic susceptibility, serotype diversity calculated. Clinical information collected for children adults with disease (IPD)....
Pneumococcal conjugate vaccine 10 (PCV10) and pneumococcal 13 (PCV13), are used in childhood immunization programs worldwide, but direct comparisons of impacts against invasive disease (IPD) equivalent populations have not been performed. We compared the vaccines (prevaccination 2007-2009 vs postvaccination 2013-2016) Sweden, where 21 counties use either PCV10 or PCV13 (introduced 2009-2010).
<h3>Rationale</h3> Host and bacterial factors as well different treatment regimens are likely to influence the outcome in patients with bacteraemic pneumococcal pneumonia. <h3>Objectives</h3> To estimate relative contribution of host antibiotic mortality <h3>Methods</h3> A cohort study 1580 adult community-acquired pneumonia was conducted between 2007 2009 Sweden. Data on initial were collected from patient records. Antibiotic resistance serotype determined for isolates. Logistic regression...
As with other pathogens, competitive interactions between Bordetella pertussis strains drive infection risk. Vaccines are thought to perturb strain diversity through shifts in immune pressures; however, this has rarely been measured because of inadequate data and analytical tools. We used 3344 sequences from 23 countries show that, on average, there 28.1 transmission chains circulating within a subnational region, the number strongly associated host population size. It took 5 10 years for B....
Administration of intravenous polyspecific immunoglobulin G (IVIG) has been proposed as adjunctive therapy for toxic shock syndrome caused by Streptococcus pyogenes or Staphylococcus aureus. We investigated whether superantigen-containing culture supernatants prepared from streptococcal isolates (n=21) and staphylococcal (n=20) cases severe sepsis were inhibited to an equal extent IVIG in proliferation experiments that used human peripheral blood mononuclear cells. All 3 preparations tested...
To evaluate the carriage prevalence, serotype distribution, and antibiotic resistance for pneumococcal isolates collected 4–8 years after introduction of conjugate vaccines (PCVs) in Stockholm, Sweden, to identify risk factors calculate invasive disease potential emerging serotypes. Nasopharyngeal aspirates were from 3024 children aged 0–<5 at regular visits 23 Child Health Centers Stockholm County 2011–2015, 787 parents 2014–2015. The was calculated serotypes using 824 patients all ages...
Recently, two related Streptococcus pyogenes strains with reduced susceptibility to ampicillin, amoxicillin, and cefotaxime, antibiotics commonly used treat S. infections, were reported. The had the same nonsynonymous (amino acid-substituting) mutation in pbp2x gene, encoding penicillin-binding protein 2X (PBP2X). This concerning report led us investigate our library of 7,025 genome sequences type emm1, emm28, emm89S. clinical recovered from intercontinental sources for mutations We...
ABSTRACT Since the late 1980s several studies have described increased incidence and severity of invasive group A streptococcal (GAS) infections. However, most on GAS pathogenesis focused information obtained during outbreaks. We analyzed isolate distribution host susceptibility as part a nationwide prospective surveillance study performed between January 2001 August 2002. isolates collected from 201 patients with infections, 335 noninvasive 17 asymptomatic carriers were characterized...
Pneumococcal conjugated vaccines (PCVs) have shown protection against invasive pneumococcal disease by vaccine serotypes, but an increase in non-vaccine serotype has been observed. Type-specific effects on clinical manifestation need to be explored. Clinical data from 2096 adults and 192 children with were correlated molecular serotypes. Invasive potential for serotypes calculated using 165 550 carriage isolates children. The was lower non-PCV13 compared vaccine-type strains. Patients...
Streptococcus pyogenes of the M1 serotype is commonly associated with large outbreaks invasive streptococcal infections and development toxic shock syndrome (STSS). The pathogenesis behind these believed to involve bacterial superantigens that induce potent inflammatory responses, but reason why strains are over-represented in STSS still not understood. In present investigation, we show a highly purified soluble form protein from S. pyogenes, which lacks membrane-spanning region, inducer T...
Abstract We conducted genetic and functional analyses of isolates from a patient with group B streptococcal (GBS) necrotizing fasciitis toxic shock syndrome. Tissue cultures simultaneously showed colonies high hemolysis (HH) low (LH). Conversely, the HH LH variants exhibited capsule (LC) (HC) expression, respectively. Molecular analysis demonstrated that 2 GBS were same clonal origin. Genetic found 3-bp deletion in covR gene HH/LC variant. Functionally, this isolate was associated an...
The incidence of invasive group A streptococcal infections in Sweden was 6.1 per 100,000 population 2012, the highest since disease became notifiable 2004. Furthermore, January and February 2013 marked a dramatic increase cases notified, partly explainable by an emm1/T1 isolates, type previously shown to cause severe more often than other types. Healthcare providers health authorities neighbouring countries have been informed about this increase.
Pneumonia is the major cause of death in children globally, with more than 900,000 deaths annually under five years age. Streptococcus pneumoniae causes most deaths, often form community acquired pneumonia. Pneumococcal conjugate vaccines (PCVs) are currently being implemented many low-income countries. PCVs decrease vaccine-type pneumococcal carriage, a prerequisite for invasive disease, and thereby affects disease transmission. In Uganda, PCV was launched 2014, but baseline data lacking...
This study describes a recent cluster of 30 patients (median age 52 years) with serious group A streptococcal (GAS) infections in Uppsala County, Sweden, from December 2006 to May 2007. Patients hospitalized severe GAS infection, i.e. cases either invasive (iGAS) disease or positive non-sterile site culture/rapid antigen test for and clinically considered as having critical disease, were included the study. Common clinical presentations skin soft tissue (53%) pneumonia (17%). Eight (27%)...
Beta-haemolytic group A streptococci (GAS) is a common cause of sore throat, usually spread person-to-person. Outbreaks related to infected food have more seldom been reported. The bacteria may originate from the throat or wounds on hands persons handling food. An outbreak in Sätila, Sweden, April/May 2003 involving 153 individuals who fell ill after eating contaminated ‘sandwich-layer cakes’ was investigated descriptive, retrospective cohort study. Questionnaires were distributed, one...
Background: Community-acquired pneumonia (CAP) is the leading cause of hospitalization among infectious diseases, and mainly caused by Streptococcus pneumoniae. Modifications were tested to improve accuracy CRB-65 as a simple but useful bedside scoring system, compare it with 3 established severity systems (PSI, CURB-65 CRB-65) predict 30-day mortality in bacteraemic pneumococcal CAP. Methods: A retrospective analysis was performed on data from 375 adult patients pneumonia. Mortality,...