A5067427124- Legionella and Acanthamoeba research
- Bacterial biofilms and quorum sensing
- Pneumonia and Respiratory Infections
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Streptococcal Infections and Treatments
- Vibrio bacteria research studies
- Antifungal resistance and susceptibility
- Water Treatment and Disinfection
- Neonatal and Maternal Infections
- Antibiotic Resistance in Bacteria
- Infective Endocarditis Diagnosis and Management
- Respiratory viral infections research
- Mycobacterium research and diagnosis
- Yersinia bacterium, plague, ectoparasites research
- Biosensors and Analytical Detection
- Bacillus and Francisella bacterial research
- Pleural and Pulmonary Diseases
- Antimicrobial Resistance in Staphylococcus
- Bacterial Infections and Vaccines
- Pneumocystis jirovecii pneumonia detection and treatment
- Psychology of Social Influence
- Peripheral Neuropathies and Disorders
- Parasitic Infections and Diagnostics
- Otolaryngology and Infectious Diseases
- Pneumothorax, Barotrauma, Emphysema
Glasgow Royal Infirmary
2014-2024
University of Edinburgh
2017-2023
Queen Elizabeth University Hospital
2023
Edinburgh Royal Infirmary
2023
University of Glasgow
2023
European Society of Clinical Microbiology and Infectious Diseases
2022-2023
Roslin Institute
2017
Glasgow Life
2015
Haemophilia Foundation Australia
2015
Stobhill Hospital
1998-2014
The 23rd World Scout Jamboree in 2015 took place Japan and included over 33,000 scouts from 162 countries. Within nine days of the meeting ending, six cases laboratory-confirmed invasive serogroup W meningococcal disease occurred among their close contacts Scotland Sweden. isolates responsible were identical to one-another by routine typing and, where known (4 isolates), belonged ST-11 clonal complex (cc11) which is associated with large outbreaks high case fatality rates. Recent studies...
Recently, two related Streptococcus pyogenes strains with reduced susceptibility to ampicillin, amoxicillin, and cefotaxime, antibiotics commonly used treat S. infections, were reported. The had the same nonsynonymous (amino acid-substituting) mutation in pbp2x gene, encoding penicillin-binding protein 2X (PBP2X). This concerning report led us investigate our library of 7,025 genome sequences type emm1, emm28, emm89S. clinical recovered from intercontinental sources for mutations We...
We characterized the epidemiology, host-pathogen characteristics, and outcomes of severe adult pulmonary Streptococcus pyogenes infections that coincided with a high community caseload in central Scotland, UK. The had illness death rates were associated socioeconomic deprivation, influenza A co-infection, M1UK lineage S. pyogenes.
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Laboratory results of 67 cases legionnaires' disease caused by Legionella pneumophila serogroup (Sg) 1 spanning a 6-year period were analysed both phenotypic and genotypic methods. The methods compared urinary antigen enzyme immunoassay (EIA), an immunofluorescent antibody (IFA) test, direct fluorescent (DFA), culture 5S rRNA PCR with Southern blotting confirmation. Urine was available in 53 cases, which 35 (66%) positive, peak observed at 5-10 days after onset symptoms. IFA test positive 62...
The mip gene of Legionella pneumophila was demonstrated by PCR and probing in paired acute-phase convalescent-phase sera from five patients with Legionnaires' disease but not the 100 pneumonia that showed no serological evidence infection. may help cases presenting diagnostic difficulty.
Four cases of legionellosis caused by Legionella longbeachae serogroup (sg) 1 were identified in Scotland from 2008 to 2010. All case patients had exposure commercially manufactured growing media or potting soils, commonly known as multipurpose compost (MPC), greenhouse conditions, prior disease onset. Two been using the same brand MPC but clinical isolates distinct genotypically amplified fragment length polymorphism (AFLP) analysis. However, an indistinguishable AFLP profile was also found...
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Abstract Legionella pneumophila, a Gram-negative bacillus, is the causative agent of Legionnaire’s disease, form severe community-acquired pneumonia. Infection can have high morbidity, with proportion patients requiring ICU admission, and up to 10% mortality, which exacerbated by lack efficacy typical empirical antibiotic therapy against spp. The fastidious nature entire Legionellaceae family historically required inclusion activated charcoal in solid medium remove growth inhibitors,...
Group B Streptococcus (GBS) is a common intestinal colonizer during the neonatal period, but also may cause late-onset sepsis or meningitis in up to 0.5% of otherwise healthy colonized infants after day 3 life. Transmission routes and risk factors this form invasive GBS disease (iGBS) are not fully understood. Cases iGBS with recurrence (n=25) those occurring parallel twins/triplets (n=32) from UK Ireland (national surveillance study 2014/15) Germany Switzerland (retrospective case...
Legionella longbeachae is the primary cause of legionellosis in Australasia and Southeast Asia an emerging pathogen Europe United States; however, our understanding population diversity L. from patient environmental sources limited. We analyzed genomes 64 isolates, which 29 were a cluster cases linked to commercial growing media Scotland 2013 35 non-outbreak-associated isolates other countries. identified extensive genetic across species, associated with intraspecies interspecies gene flow,...
Legionella pneumophila is the most common cause of severe respiratory infection known as Legionnaires' disease. However, microorganism typically a symbiont free-living amoeba, and our understanding bacterial factors that determine human pathogenicity limited. Here we carried out population genomic study 902 L. isolates from clinical environmental samples to examine their genetic diversity, global distribution basis for pathogenicity. We find capacity disease representative breadth species...
Strains of type emm89 Streptococcus pyogenes have recently increased in frequency as a cause human infections several countries Europe and North America. This increase has been molecular epidemiologically linked with the emergence new genetically distinct clone, designated clade 3. We sought to extend our understanding this epidemic behavior by genetic characterization strains responsible recent years for an Scotland.We sequenced genomes retrospective cohort 122 recovered from patients...
Application of a SERS DNA detection assay for the identification bacterial meningitis pathogens in clinical samples.
Legionella pneumophila serogroup 1 (Lp1) sequence type (ST) 23 is one of the most commonly detected STs in Italy where it currently causes all investigated outbreaks. ST23 has caused both epidemic and sporadic cases between 1995 2018 was analysed at genomic level compared with isolated other countries to determine possible similarities differences. A core genome multi-locus typing (cgMLST), based on a previously described set 1,521 genes, single-nucleotide polymorphisms (SNPs) approaches...