A5035751968- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Airway Management and Intubation Techniques
- Pneumonia and Respiratory Infections
- Infectious Diseases and Tuberculosis
- Asthma and respiratory diseases
- Medical Imaging and Pathology Studies
- Reproductive System and Pregnancy
- Pharmacological Effects of Natural Compounds
- Dysphagia Assessment and Management
- Antibiotics Pharmacokinetics and Efficacy
- HIV/AIDS drug development and treatment
- Antibiotic Use and Resistance
- Colorectal Cancer Treatments and Studies
- Allergic Rhinitis and Sensitization
- Nosocomial Infections in ICU
- Respiratory and Cough-Related Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biosimilars and Bioanalytical Methods
- Cancer survivorship and care
Onze Lieve Vrouwziekenhuis Hospital
2023-2025
Centre Hospitalier Universitaire de Saint-Pierre
2011-2019
Université Libre de Bruxelles
2018-2019
Karolinska Institutet
2015
Institut Universitari d'Investigació en Atenció Primària Jordi Gol
2015
Vall d'Hebron Hospital Universitari
2015
Queen Mary University of London
2015
KU Leuven
2013
Drug-resistant Mycobacterium tuberculosis is challenging elimination of (TB). We evaluated risk factors for TB and levels second-line drug resistance in M. patients Europe with multidrug-resistant (MDR) TB. A total 380 MDR 376 non-MDR were enrolled at 23 centers 16 countries during 2010-2011. 52.4% had never been treated TB, which suggests primary transmission tuberculosis. At initiation treatment 59.7% strains tested resistant to pyrazinamide, 51.1% ≥1 drug, 26.6% injectable drugs, 17.6%...
Mycobacterium tuberculosis strains resistant to almost all available anti-tuberculosis drugs are an increasing threat public health worldwide. Among existing with potential antimycobacterial effects, the combination of meropenem clavulanate has been shown have potent in vitro bactericidal activity against extensively drug-resistant (XDR-TB). To explore its clinical efficacy, a meropenem-clavulanate-containing salvage regimen was started six patients severe pulmonary XDR-TB, association only...
To evaluate the access to comprehensive diagnostics and novel antituberculosis medicines in European countries.
The combination of meropenem with clavulanate has high antimycobacterial activity in vitro against extensively drug-resistant Mycobacteriumtuberculosis strains. We report the successful use this association linezolid management an advanced tuberculosis disease complex second-line drug resistance a 14-year-old teenager.
Background Immunotherapy represents a recent milestone in the treatment of lung cancer, particularly with rapidly expanding development monoclonal antibodies targeting checkpoint inhibitors programmed cell death-1 (PD-1) pathway, such as nivolumab and pembrolizumab. Classical auto-immune side effects these treatments, often called immune-related adverse events (irAEs), can affect multiple organs, including lungs which potentially life-threatening pneumonitis may require rapid high doses...
Abstract Background and objective Antimicrobial resistance (AMR) is a global crisis, however, relatively little known regarding its impact in chronic respiratory disease the specific challenges faced by healthcare workers across world this field. We aimed to assess worker views on they face AMR disease. Methods An online survey was sent globally working through European Respiratory Society clinical research collaboration (AMR-Lung) focussed lung Responses from different geographic regions...
<sec><title>BACKGROUND</title>Anecdotal information suggests that clinical practice regarding the use of putative hepatoprotective agents in TB treatment varies across countries WHO European Region.</sec><sec><title>METHODS</title>Between November 2023 and May 2024, we conducted a standardised questionnaire survey on patients receiving among Tuberculosis Network Trials Group (TBnet) representatives...
Multidrug-resistant tuberculosis (MDR-TB) is a major burden to public health in Europe. Reported treatment success rates are around 50% or less, and cure even lower.To document the management outcome patients with MDR-TB Europe.We performed prospective cohort study, analyzing outcomes stratified by incidence of Treatment were compared World Health Organization alternative simplified definitions Tuberculosis Network European Trialsgroup (TBNET).A total 380 recruited followed up between 2010...
Background European-specific policies for tuberculosis (TB) elimination require identification of key populations that benefit from TB screening. Aim We aimed to identify groups foreign-born individuals residing in European countries most targeted prevention Methods The Tuberculosis Network Trials group collected, by cross-sectional survey, numbers patients Union (EU) countries, Iceland, Norway, Switzerland and the United Kingdom (UK) 2020 10 highest ranked origin terms cases each country...
The emergence of drug-resistant tuberculosis (TB) is a challenge to TB control in Europe.We evaluated secondline drug susceptibility testing Mycobacterium isolates from patients with multidrugresistant, pre-extensively (pre-XDR-TB) and XDR-TB at 23 TBNET sites 16 European countries.Over 30% bacilli pre-XDR-TB showed resistance any fluoroquinolone almost 70% second-line injectable drug.Respec
Objectives: To determine whether the incidence of tuberculosis with pregnancy is more common than would be expected from crude birth rate; to see there significant delay in diagnosis during pregnancy. Design: A cross-sectional survey. Setting: 13 clinics within different European countries and USA. Population/sample: All patients seen at these for a period > 1 year. Instrument: Questionnaire survey based on continuous data collection. Main outcome measures: number proportion women who were...
Extensively drug-resistant tuberculosis (XDR-TB), defined as TB caused by a Mycobacterium strain resistant to at least rifampicin, isoniazid, any fluoroquinolone and one of the injectable anti-tuberculosis drugs, remains worldwide public health threat. Among repurposed drugs empirically used for XDR-TB cases, carbapenems have been studied in vitro animal models, with encouraging results. However, only short-term follow-up data from clinical studies are currently available.To study long-term...
<b><i>Background:</i></b> Hypoxemia is a frequent adverse event occurring during flexible bronchoscopy and usually prevented by close monitoring and, if needed, oxygen supplementation nasal cannula. <b><i>Objective:</i></b> We aim to demonstrate that tracheal feasible, safe effective method restore saturation levels after desaturation. <b><i>Methods:</i></b> In first phase, we compare the or route in single blinded...
Abstract NK cells were recently suggested to be important for the initial control of M. tuberculosis infection. The phenotypes 3 main blood subsets, CD56bright, CD56dim, and CD56neg cells, characterized by flow cytometry in a cohort 81 prospectively enrolled subjects (21 untreated patients with active -aTB-, 35 latently TB infected -LTBI- subjects, 25 non-infected controls), using 9 different mAbs added whole blood. Compared LTBI aTB had lower proportions total numbers expressing early...
Abstract: Non-small cell lung cancer can exhibit driver oncogenes, including epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK), that are possible targets for therapy. The prevalence of these rearranged oncogenes is influenced by race, smoking habits, gender. Most data come from Caucasian Asian populations. To our knowledge, there no literature available about the in Sub-Saharan Africa, where tobacco epidemic still early stage. In this small case series, 6 patients...
Background: For patients receiving therapy with curative or palliative intent for a thoracic malignancy, prediction of quality life (QOL), once starts, remains challenging. The role health assessments by the patient instead doctor herein ill-defined. Aims: To assess evolution QOL in malignancies treated and intent, respectively. identify factors that determine one year after start cancer therapy. affect survival. Methods: We prospectively included consecutive malignancy who were starting...
<b>Introduction:</b> maximal voluntary ventilation (MVV) correlates well with exercise capacity and is used to assess the ventilatory function during in COPD patients. Dynamic hyperinflation (DH) often occurs MVV believed be due expiratory flow limitation. The present study has assessed whether DH can also occur normal subjects without <b>Methods:</b> 43 (25 men) lung performed at increasing breathing frequencies tidal volume, from 10 100 cycles per minute. Inspiratory (IC) was measured rest...