A5028028790- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral gastroenteritis research and epidemiology
- Rheumatoid Arthritis Research and Therapies
- COVID-19 Impact on Reproduction
- Pediatric health and respiratory diseases
- Escherichia coli research studies
- Microbial infections and disease research
- Vaccine Coverage and Hesitancy
- Pregnancy and preeclampsia studies
- Streptococcal Infections and Treatments
- Pharmacovigilance and Adverse Drug Reactions
- Global Maternal and Child Health
- Herpesvirus Infections and Treatments
- Whipple's Disease and Interleukins
- Respiratory viral infections research
- Celiac Disease Research and Management
- Microscopic Colitis
- Musculoskeletal synovial abnormalities and treatments
- Legionella and Acanthamoeba research
- Viral Infections and Outbreaks Research
Public Health Agency of Sweden
2014-2025
Karolinska University Hospital
1960-2023
Karolinska Institutet
2013-2021
Swedish Institute
2011-2018
Instituto de Salud Carlos III
2005-2011
Centro Nacional de Epidemiología
2005-2006
European Centre for Disease Prevention and Control
2005
Stockholm University College of Music Education
2003
Ericsson (Sweden)
1961
Large studies on bedaquiline used to treat multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB) are lacking. This study aimed evaluate the safety effectiveness of bedaquiline-containing regimens in a large, retrospective, observational conducted 25 centres 15 countries five continents.428 culture-confirmed MDR-TB cases were analysed (61.5% male; 22.1% HIV-positive, 45.6% XDR-TB). admitted hospital for median (interquartile range (IQR)) 179 (92-280) days exposed 168...
<h3>Importance</h3> The outcomes of newborn infants women testing positive for SARS-CoV-2 in pregnancy is unclear. <h3>Objective</h3> To evaluate neonatal relation to maternal test positivity pregnancy. <h3>Design, Setting, and Participants</h3> Nationwide, prospective cohort study based on linkage the Swedish Pregnancy Register, Neonatal Quality Register Communicable Diseases. Ninety-two percent all live births Sweden between March 11, 2020, January 31, 2021, were investigated by 8, 2021....
The World Health Organization (WHO) recommends that countries implement pharmacovigilance and collect information on active drug safety monitoring (aDSM) management of adverse events.The aim this prospective study was to evaluate the frequency severity events anti-tuberculosis (TB) drugs in a cohort consecutive TB patients treated with new (i.e. bedaquiline, delamanid) repurposed clofazimine, linezolid) drugs, based WHO aDSM project. Adverse were collected prospectively after attribution...
In the European Union (EU) 72,334 tuberculosis (TB) cases were notified in 2011, of which 16,116 (22%) had extrapulmonary (EPTB). The percentage TB with EPTB ranged from 4% to 48% reporting countries. This difference might be explained by differences risk factors for or challenges diagnosis. To assess practices diagnosis we asked Union/European Economic Area (EU/EEA) countries participate a report describing diagnostic procedures and diagnosing EPTB. Eleven EU Member States participated...
Objective To estimate the risk of tuberculosis (TB) in patients with rheumatoid arthritis (RA) both and without exposure to biological therapy directly compare risks between therapies. Methods Data from Swedish National Population Registers, Tuberculosis Register Biologics were used conduct a prospective population-based national cohort study (2002–2011). We estimated rate incident TB general population biological-naïve biological-exposed diagnosed RA. Cox models HRs particular attention by...
Background As tuberculosis (TB) incidence rates decrease faster in native than migrant populations European countries, addressing health becomes increasingly important TB programmes. Aim To inform prevention and control policies, we analysed data on migrants low TB-incidence countries (TB < 10/100,000 population) during 2014–2020 by origin, destination, recent vs non-recent immigration. Methods Data patients were derived from the Surveillance System (TESSy) Eurostat or national...
<title>Abstract</title> <bold>Introduction:</bold> In low TB incidence countries, prevention and care activities addressing migrants are essential for control. Understanding characteristics of the migrant patient population is important planning providing appropriate care. This study aims to inform strategies by describing subpopulations in Europe understand whether differences exist their profiles. <bold>Methods:</bold> cross-sectional descriptive among patients reported European...
Rationale Studies investigating the risk of active tuberculosis (TB) in association with pregnancy have not been conclusive. We aimed to investigate this a large retrospective register-based cohort study Sweden. Methods Data from women 15–49 years age who had given birth Sweden between 2005 and 2013 were extracted national childbirth register linked TB register. Cohort time was divided into three exposure periods: during pregnancy, six months (180 days) postpartum neither pregnant nor...
In low-incidence countries in the European Union (EU), tuberculosis (TB) is concentrated big cities, especially among certain urban high-risk groups including immigrants from TB high-incidence countries, homeless people, and those with a history of drug alcohol misuse. Elimination cities requires control measures focused on multiple layers population. The particular complexities major EU metropolises, for example high population density social structure, create specific opportunities...
The World Health Organization (WHO) recommends countries introduce new anti-TB drugs in the treatment of multidrug-resistant tuberculosis. aim study is to prospectively evaluate effectiveness bedaquiline (and/or delamanid)- containing regimens a large cohort consecutive TB patients treated globally. This observational, prospective based on data collected and provided by Global Tuberculosis Network (GTN) centres analysed twice year. All (including children/adolescents) with and/or delamanid...
Objective Interferon gamma release assays like Quantiferon Gold In-Tube (QFT) are used to identify individuals infected with Mycobacterium tuberculosis. A dichotomous cut-off (0.35 IU/ml) defines a positive QFT without considering test variability. Our objective was evaluate the introduction of borderline range under routine conditions. Methods Results samples from Sweden (2009–2014) were collected. (0.20–0.99 introduced in 2010 recommending follow-up sample. The association between results...
Linezolid treatment has a high risk of toxicity and adverse drug reactions (ADR) are frequent. Few studies have investigated factors major ADRs separately, therefore, we aimed to evaluate including peripheral neuropathy in relation concentration levels linezolid high-resource setting for multidrug-resistant tuberculosis (MDR-TB). We conducted retrospective cohort study participants treated with linezolid-containing MDR-TB regimen Sweden 1992–2018. Data was collected from medical records....
Aliment Pharmacol Ther 2011; 33: 689–696 Summary Background Research suggests a positive association between coeliac disease and tuberculosis (TB), but that research has often been limited to in-patients small sample size. We examined the relationship TB disease. Aim To examine of Methods collected biopsy data from all pathology departments in Sweden (n = 28) identify individuals who were diagnosed with 1969 2007 (Marsh 3: villous atrophy; n 29 026 unique individuals). Population-based sex-...
Our aim was to analyze the difference between methods for genotyping of Mycobacterium tuberculosis complex isolates. We collected results from Restriction Fragment Length Polymorphism (RFLP) and Mycobacterial Interspersed Repetitive Units - Variable Numbers Tandem Repeat (MIRU-VNTR) in a geographically limited area (Stockholm) during period three years. The number proportion isolates belonging clusters reduced by 45 35% respectively when combining two compared with using RFLP or MIRU-VNTR...
Vaccines against SARS-CoV-2 are highly effective in preventing severe disease and mortality. Although pregnant women at increased risk of COVID-19, vaccination uptake among varies. We used the Swedish Norwegian population-based health registries to identify investigate background characteristics associated with not being vaccinated. In this study 164 560 giving birth between May 2021 2022, 78% Sweden 87% Norway have been vaccinated least one dose delivery. Not while was age below 30 years,...
SummaryObservations are reviewed which suggest that venereal infection may be a factor contributing to the development of Reiter's syndrome and related types arthritis. Of agents thus transmitted, so-called pleuropneumonia-like or mycoplasma organisms those most likely involved. Bloodborne spread assumed underly articular manifestations, since their presence in synovial fluid arthritic joints has occasionally been demonstrated culturally by number investigators.In present study,...
Objective To assess associations of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and pregnancy outcomes considering testing policy test‐positivity‐to‐delivery interval. Design Nationwide cohort study. Setting Sweden. Population From the Pregnancy‐Register we identified 88 593 singleton births, 11 March 2020–31 January 2021, linked to data on SARS‐CoV‐2‐positivity from Public Health Agency, information neonatal care admission Neonatal Quality Register. Adjusted odds...
Quantiferon-TB Gold Plus (QFT-Plus) is an interferon gamma release assay used to diagnose latent tuberculosis (LTB). A borderline range (0.20 0.99 IU/ml) around the cutoff (0.35 has been suggested for earlier QFT version.
Abstract Introduction The majority of tuberculosis (TB) cases in Sweden occur among migrants from endemic countries through activation latent infection (LTBI). has LTBI-screening policies for that have not been previously evaluated. This study aimed to assess the cost-effectiveness current screening strategy Stockholm. Methods A Markov model was developed predict costs and effects program compared a scenario no LTBI over 50-year time horizon. Epidemiological cost data were obtained local...
Rheumatoid arthritis is a risk factor for tuberculosis (TB), particularly following treatment with biologic agents. Since these therapies are increasingly used in ankylosing spondylitis (AS), other types of spondyloarthritis (SpA), and psoriatic (PsA), we investigated the corresponding TB risks patients.We identified individuals AS/SpA/PsA, non-AS/SpA/PsA comparators by linking Swedish national patient, population, TB, rheumatology registers, followed them occurrence. Incidence rates were...