A5017237980- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Obstructive Sleep Apnea Research
- Medical Imaging and Pathology Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sarcoidosis and Beryllium Toxicity Research
- Tuberculosis Research and Epidemiology
- Drug-Induced Adverse Reactions
- Lung Cancer Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Neuroscience of respiration and sleep
- Patient Dignity and Privacy
- Cystic Fibrosis Research Advances
- Pneumothorax, Barotrauma, Emphysema
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- Parasites and Host Interactions
- Inhalation and Respiratory Drug Delivery
- Congenital Diaphragmatic Hernia Studies
- COVID-19 Clinical Research Studies
- Parasitic Diseases Research and Treatment
- Neonatal Respiratory Health Research
- Cardiac, Anesthesia and Surgical Outcomes
Vilnius University
2016-2025
Edinburgh Royal Infirmary
2022
Saratov State University
2022
Vilnius University Hospital Santariskiu Klinikos
2010-2022
Karolinska University Hospital
2021
Karolinska Institutet
2021
American College of Chest Physicians
2009
The World Health Organization (WHO) recommends that countries implement pharmacovigilance and collect information on active drug safety monitoring (aDSM) management of adverse events.The aim this prospective study was to evaluate the frequency severity events anti-tuberculosis (TB) drugs in a cohort consecutive TB patients treated with new (i.e. bedaquiline, delamanid) repurposed clofazimine, linezolid) drugs, based WHO aDSM project. Adverse were collected prospectively after attribution...
The World Health Organization (WHO) recommends countries introduce new anti-TB drugs in the treatment of multidrug-resistant tuberculosis. aim study is to prospectively evaluate effectiveness bedaquiline (and/or delamanid)- containing regimens a large cohort consecutive TB patients treated globally. This observational, prospective based on data collected and provided by Global Tuberculosis Network (GTN) centres analysed twice year. All (including children/adolescents) with and/or delamanid...
Background and Objectives: Kidney transplant recipients are at risk of developing more severe forms COVID-19 infection. The aim this study was to compare the clinical course infection among kidney patients a control group. Materials Methods: We examined 150 hospitalized with Patients were divided into (kidney recipients, n = 53) (without history transplantation, 97) groups. Demographics, characteristics, treatment data, outcomes assessed. Results: median patient age 56.0 (46.0–64.0) years,...
Euthanasia and assisted suicide, involving the intentional termination of a patient’s life, are subjects global debate influenced by cultural, ethical, religious beliefs. This study explored attitudes general public toward euthanasia, finding varying levels support. A cross-sectional was conducted. research specifically evaluated perspectives 5804 Lithuanian residents using survey distributed through social media, which presented medical scenarios on life-preserving interventions. Analysis...
Background: The aim of the present study was to identify specious radiologic and/or physiologic prognostic marker(s), which lead optimize patient follow-up frequency. Methods: Eighty consecutive patients with newly diagnosed pulmonary sarcoidosis. Patients underwent chest radiography, high-resolution computed tomography (HRCT) examination, function tests (PFT), bronchoscopy bronchoalveolar lavage (BAL) and lung biopsy, fluid (BALF) cell examination. Results: reduction in PFT values seen...
The topic of end-of-life decisions is important due to aging populations and the rising number terminal illnesses like cancer. As more people experience suffering, ethical, medical, legal debates these become significant healthcare policy. Understanding medical professionals' attitudes critical for shaping responsible practices legislation surrounding care. This cross-sectional study explores Lithuanian physicians toward assistance in dying (MAID), including euthanasia assisted suicide...
Purpose: To determine central corneal thickness (CCT) and the parameters in patients with obstructive sleep apnea (OSA), evaluate relationship between severity of OSA, minimum peripheral capillary oxygen saturation (min. SpO 2 ), morphological characteristics. Methods: Patients OSA diagnosed by full-night polysomnography before treatment were included. divided into 3 groups according to Apnea–Hypopnea Index (AHI). The control group (CG) was examined exclude possibility ocular diseases....
Drug-resistant tuberculosis (TB) is an important public health problem in Lithuania with MDR rates new cases reaching 11% 2012. Currently available diagnostic tools are not fully adequate for accurate and rapid result diagnosis of TB MDR-TB.To evaluate the performance Xpert(®) MTB/RIF assay early detection rifampicin (RIF) resistance routine settings Lithuania.A total 833 individual respiratory samples obtained from patients previously treated MDR-TB contacts were tested using Xpert assay....
The mechanisms driving the transition from inflammation to fibrosis in sarcoidosis patients are poorly understood; prognostic features lacking. Immune cell profiling may provide insights into pathogenesis and factors of disease. This study aimed establish associations simultaneous lymphocyte subset profiles blood, bronchoalveolar lavage fluid (BALF), lung biopsy tissue with newly diagnosed sarcoidosis.A total 71 sarcoid (SPs) 20 healthy controls (HCs) were enrolled study. CD31, CD38, CD44,...
We present an extremely rare manifestation of dirofilariasis in the pleural cavity. This is first human pulmonary reported Lithuania; according to our knowledge, only two other patients were documented with this pathology world.
Background/Aim: Severe pulmonary influenza A virus (IAV) infection causes lung inflammation and expression of inducible nitric oxide synthase (iNOS), leading to overproduction (NO). We studied whether zanamivir reduces through inhibition NO production in mice. Materials Methods: treated IAV-infected mice daily with intranasal zanamivir. Controls were infected either placebo-treated or untreated, not placebo-treated. Mice weighed daily. After euthanasia on day 3, lungs excised bronchoalveolar...
Background and Objective: Respiratory assistance tactic that is best for COVID-19-associated acute hypoxemic respiratory failure (AHRF) individuals has yet to be determined. Patients with AHRF may benefit from the use of a high-flow nasal cannula (HFNC) non-invasive ventilation (NIV). The goals this prospective observational research were estimate predictive factors HFNC NIV in COVID-19-related subjects. Materials Methods: enlisted participation 124 patients. A stepwise treatment approach...
Tyrimo tikslas. Išnagrinėti pleuros empiemos ir komplikuoto parapneumoninio pleurito priežastis rizikos veiksnius. Tirtųjų kontingentas tyrimo metodai. Ištirta 120 ligonių, sirgusių empiema (n=67) komplikuotu parapneumoniniu pleuritu (n=53). Pleuros diagnozuota radus pūlingo skysčio. Komplikuotas parapneumoninis pleuritas diagnozuotas ultragarsiniu tyrimu, aptikus inkapsuliuoto skysčio ertmėje, pH<7,0 bei skystyje nustačius neutrofilų daugiau kaip 50 proc. visų leukocitų. tikslas –...
The Khorana score may help physicians to identify patients at high risk of Pulmonary embolism (PE) and decide who is eligible for thromboprophylaxis, however, its role in lung cancer remains unclear.The aim this study was evaluate association between the PE development among advanced stage inpatients treated with chemotherapy.A retrospective cohort included 2008-2017 year data 217 IIIB IV clinical stages receiving chemotherapy. evaluated were divided two groups: a group 1 point 2 or more...
Background and Objective: Obstructive sleep apnea (OSA) is a heterogeneous chronic associated disorder. A common apnea-hypopnea index (AHI)-focused approach to OSA severity evaluation not sufficient enough capture the extent of related risks, it limits our understanding disease pathogenesis may contribute modest response conventional treatment. In order resolve heterogeneity issue, patients can be divided into more homogenous therapeutically prognostically significant groups-phenotypes. An...
Background/Aim: The prognostic role of thyroid transcription factor-1 (TTF1) in advanced lung cancer is not clearly established. present study aimed to evaluate the associations between clinicopathological characteristics, TTF1 expression, and overall survival (OS) patients with adenocarcinoma. Materials Methods: One hundred seventy-two were enrolled this retrospective study. OS was assessed according immunohistochemical expression adenocarcinoma tissue, age, gender, performance status (PS),...
ANCA-associated vasculitis (AAV) is an inflammatory systemic disorder affecting small to medium sized vessels and likely leading any organ dysfunction. Adequate treatment important avoid mortality or severe damage. In most cases initial (induction therapy) allows achieve remission. Induction therapy leads immunosuppression may cause infections. However, in patients even intensive immunosuppressive rarely complicated by invasive fungal infection. We present a case 29-year old male patient...
We evaluated the effect of antihyperglycemic therapy on survival patients with lung cancer (LC). The analysis included LC and concomitant type 2 diabetes. 15,929 were classified into five groups: metformin users, insulin sulphonylurea users non-diabetic group. A multivariate showed that exposure to either or was associated a lower risk LC-specific mortality, this approached statistical significance (HR 0.82, 95% CI 0.72-92 for HR 0.65, 0.44-95 insulin). When deaths from all causes...
<b>Background:</b> obesity is considered a major risk factor of obstructive sleep apnea (OSA). Studies shows that weight loss reduces apnea-hypopnea index (AHI). However there still debate if continuous positive airway pressure (CPAP) therapy helps to lose or leads gain in patients. <b>Aims:</b> evaluate (body mass - BMI) changes after 3 and 9 months CPAP initiation OSA <b>Methods:</b> prospective study was performed. Patients diagnosed with whom prescribed were included. BMI analyzed....