A5046780212- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Sleep and related disorders
- Heart Rate Variability and Autonomic Control
- Circadian rhythm and melatonin
- Restless Legs Syndrome Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Cardiovascular Syncope and Autonomic Disorders
- Sleep and Work-Related Fatigue
- Tracheal and airway disorders
- Non-Invasive Vital Sign Monitoring
- Airway Management and Intubation Techniques
- Cardiovascular and Diving-Related Complications
- EEG and Brain-Computer Interfaces
- Asthma and respiratory diseases
- Dysphagia Assessment and Management
- Health and Medical Studies
- Parkinson's Disease Mechanisms and Treatments
- Voice and Speech Disorders
- Cardiovascular Health and Disease Prevention
- Gastroesophageal reflux and treatments
- Intensive Care Unit Cognitive Disorders
- Cardiovascular and exercise physiology
Charité - Universitätsmedizin Berlin
2016-2025
Woolcock Institute of Medical Research
2024
Southwest Medical University
2023-2024
Fourth People's Hospital of Taiyuan
2021-2024
Humboldt-Universität zu Berlin
1997-2023
University of Gothenburg
2023
Freie Universität Berlin
2018-2023
The Fourth People's Hospital
2022-2023
Zigong First People's Hospital
2023
Sahlgrenska University Hospital
2023
How did the study come about?Although in past century mortality West Germany decreased similarly as other Western nations, these changes were less pronounced East Germany. 1,2After German reunification 1990, there was a lack of scientifically valid data from to explain regional differences life expectancy and, consequently, need for population-based research northeast
In view of the high prevalence and relevant impairment patients with obstructive sleep apnoea syndrome (OSAS) lots methods are offered which promise definitive cures for or improvement OSAS. This report summarises efficacy alternative treatment options in An interdisciplinary European Respiratory Society task force evaluated scientific literature according to standards evidence-based medicine. Evidence supports use mandibular advancement devices mild moderate Maxillomandibular osteotomy...
Abstract Identification of obstructive sleep apnea and risk factors is important for reduction in symptoms cardiovascular risk, improvement quality life. The population‐based Study Health Pomerania investigated clinical diseases a general population northeast Germany. Additional polysomnography was applied to measure respiration with the objective assessing prevalence German cohort. One‐thousand, two‐hundred eight people between 20 81 years old (54% men, median age 54 years) underwent...
Primary treatment of obstructive sleep apnea can be accompanied by a persistence excessive sleepiness despite adherence. Furthermore, effectiveness is limited poor Currently available pharmacologic options for the in this population are limited.
Background In view of the reduced number hours devoted to sleep in modern western societies question arises what effects might result from duration on occurrence chronic diseases. Methods Data 23 620 middle-aged participants European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study, that were recruited between 1994–1998, analyzed by using Cox proportional hazard regression examine association self-reported at baseline incidence diseases, such as diabetes, myocardial...
Weight reduction is a standard recommendation for obstructive sleep apnea (OSA) treatment in people with obesity or overweight; however, weight loss can be challenging to achieve and maintain without bariatric surgery. Currently, no approved anti-obesity medication has demonstrated effectiveness OSA management. This study evaluating the efficacy safety of tirzepatide moderate severe obesity. SURMOUNT-OSA, randomized, placebo -controlled, 52-week phase 3 trial, investigating (apnea hypopnea-...
Studies from the USA have reported that sleep apnoea is common in congestive heart failure (CHF), with Cheyne-Stokes respiration (CSR) being most frequent type of sleep-disordered breathing (SDB) these patients. Within present study, authors sought to assess prevalence and SDB among CHF patients Germany. A total 203 participated this prospective multicentre study. All were stable New York Heart Association classes II III had a left ventricular ejection fraction (LVEF)<40%. The investigated...
A carefully designed study assessed the short-term (single dose) and long-term (14 days with multiple dosage) effects of a valerian extract on both objective subjective sleep parameters. The investigation was performed as randomised, double-blind, placebo-controlled, cross-over study. Sixteen patients (4 male, 12 female) previously established psychophysiological insomnia (ICSD-code 1.A.1.), median age 49 (range: 22 to 55), were included in main inclusion criteria reported primary according...
Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10% in the general population above 65 years age. Affected individuals suffer from uncomfortable sensations and urge move lower limbs that occurs mainly resting situations during evening or at night. Moving walking leads improvement symptoms. Concomitantly, patients report sleep disturbances consequences such as reduced daytime functioning. We conducted genome-wide association study (GWA) for...
Systemic hypertension is associated with obstructive sleep apnoea syndrome (OSAS) but the pathophysiological mechanisms are incompletely understood. A collaborative European network of 24 centres established a Sleep Apnoea Database to evaluate cardiovascular morbidity OSAS. 11 911 adults referred suspected OSAS between March 2007 and September 2013 underwent overnight studies, either cardiorespiratory polygraphy or polysomnography. We compared predictive value apnoea–hypopnoea index (AHI) 4%...
The European Sleep Apnoea Database (ESADA) reflects a network of 22 sleep disorder centres in Europe enabled by COST action B26 programme. This ongoing project aims to describe differences standard clinical care patients with obstructive apnoea (OSA) and establish resource for genetic research this disorder. Patients suspected OSA are consecutively included followed up according local standards. Anthropometrics, medical history, medication, daytime symptoms data (polysomnography or...
To evaluate the dose-response relationship of daridorexant, a new dual orexin receptor antagonist, on sleep variables in subjects with insomnia disorder.Adults (≤64 years) disorder were randomized (1:1:1:1:1:1) to receive daily oral placebo, daridorexant (5, 10, 25, or 50mg), 10mg zolpidem for 30 days. The primary efficacy outcome was change wake time after onset from baseline days 1 and 2. Secondary measures latency persistent 2, subjective onset, week 4. Safety also assessed.Of 1,005...
Objectives/Hypothesis This feasibility study was designed to show the preliminary safety and efficacy of targeted hypoglossal neurostimulation (THN), identify baseline predictors successful therapy. Study Design Open‐label, prospective, multicenter, single‐arm cohort study, conducted at seven centers in U.S.A. Europe. Methods Forty‐six participants with moderate severe obstructive sleep apnea (OSA), failing or intolerant continuous positive airway pressure, were implanted. Primary...
<ns4:p>Sleep medicine has been an expanding discipline during the last few decades. The prevalence of sleep disorders is increasing, and centers are in hospitals private care environment to meet demands. Sleep evidence-based guidelines for diagnosis treatment disorders. However, number caregivers this area not sufficient. Many new methods recording diagnosing have developed. chronic conditions require continuous monitoring therapy success. Cost-efficient technologies initial follow-up...
Sleeping problems are prevalent among children and adolescents, often leading to frequent consultations with pediatricians. While cognitive-behavioral therapy has shown effectiveness, especially in the short term, there is a lack of globally endorsed guidelines for use pharmaceuticals or over-the-counter remedies managing sleep onset insomnia. An expert panel pediatric specialists chronobiologists met October 2023 develop practical recommendations pediatricians on management insomnia...
Ballet dancers are competitive athletes who undergo extreme physical and mental stress work according to an irregular schedule, with long days of training, rehearsal, performance. Their most significant potential risks entail injury altered sleep. The elaborate training requirements for ballet do not allow regular chronobiological patterns or a normal sleep-wake rhythm. Our aim was investigate the rhythm sleep quality during rehearsal phases prior premiere. We used wrist actigraphy diaries...
Obstructive sleep apnoea (OSA) is associated with increased risk of dysglycaemia but the intimate link these conditions obesity makes discerning an independent relationship between them challenging. Glycosylated haemoglobin (HbA1c) levels predict adverse cardiovascular outcomes in nondiabetics there a lack population-level data exploring HbA1c OSA. A cross-sectional analysis 5294 participants multinational European Sleep Apnoea Cohort (European Database) study was performed, assessing OSA...