A5004682309- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic function and diabetes
- Obstructive Sleep Apnea Research
- Vitamin D Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Ovarian function and disorders
- Diabetes Management and Research
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Lipoproteins and Cardiovascular Health
- Drug Transport and Resistance Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Biomarkers in Disease Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Bone Metabolism and Diseases
- Cardiovascular Function and Risk Factors
- Blood properties and coagulation
- Liver Disease Diagnosis and Treatment
- Antioxidant Activity and Oxidative Stress
- Neuroscience of respiration and sleep
- Peptidase Inhibition and Analysis
University of Pavol Jozef Šafárik
2013-2024
Univerzitná Nemocnica Louisa Pasteura
2006-2024
Kuopio University Hospital
2009
OBJECTIVE We evaluated insulin sensitivity and secretion across the entire range of fasting (FPG) 2-h plasma glucose (PG), we investigated differences in release different tolerance categories. RESEARCH DESIGN AND METHODS A total 6,414 Finnish men (aged 57 ± 7 years, BMI 27.0 3.9 kg/m2) from our ongoing population-based METSIM (Metabolic Syndrome Men) study were included. Of these subjects, 2,168 had normal tolerance, 2,859 isolated impaired (IFG), 217 (IGT), 701 a combination IFG IGT, 469...
Systemic hypertension is associated with obstructive sleep apnoea syndrome (OSAS) but the pathophysiological mechanisms are incompletely understood. A collaborative European network of 24 centres established a Sleep Apnoea Database to evaluate cardiovascular morbidity OSAS. 11 911 adults referred suspected OSAS between March 2007 and September 2013 underwent overnight studies, either cardiorespiratory polygraphy or polysomnography. We compared predictive value apnoea–hypopnoea index (AHI) 4%...
Pharmacogenetic studies revealed that variants in genes related to the pharmacokinetics of metformin were associated with glucose‐lowering effect metformin. The aim this study was investigate possible associations encoding organic cationic transporters–solute carrier family 22, members A1, A2 ( SLC22A1 , SLC22A2 ) and solute 47, member A1 SLC47A1 response type 2 diabetes. One hundred forty‐eight drug‐naive patients diabetes included study. Genotyping for rs622342, rs316019 rs2289669...
The aim of the present study was to analyse effects sulphonylurea treatment on parameters glycaemic control in relation transcription factor 7-like 2 (TCF7L2) genotypes. In 87 patients with type diabetes who failed achieve metformin monotherapy, 6-month addition reductions haemoglobin A1c (HbA1c) and fasting plasma glucose (FPG) levels were evaluated. Reduction HbA1c FPG response significantly higher CC genotype compared those CT+TT (1.16 ± 0.07 vs. 0.86 0.07%, p = 0.003; 1.57 0.12 1.14 0.14...
Gliptins act by increasing endogenous incretin levels. Glucagon-like peptide-1 receptor (GLP1R) and glucose-dependent insulinotropic peptide (GIPR) are their indirect drug targets. Variants of GLP1R GIPR have previously been associated with the effect. The aim present pilot study was to examine associations gene variants glycaemic response gliptins. A total 140 consecutive patients type 2 diabetes were followed-up 6 months after initiation gliptin treatment. rs6923761 (Gly168Ser) rs10423928...
Background:We aimed to analyse quantitative effects of treatment with sulphonylurea in addition metformin on parameters glycemic control relation KCNQ1 genotypes, and identify factors predictive for the response treatment.Material/Methods:Effect 6-month therapy according genotypes was evaluated 87 patients type 2 diabetes who failed achieve monotherapy. rs163184 (T>G) polymorphism determined by real-time PCR melting analysis unlabeled probe.Results:The reduction fasting plasma glucose (ΔFPG)...
Previous studies showed associations between variants in TCF7L2 gene and the therapeutic response to sulfonylureas. All sulfonylureas stimulate insulin secretion by closure of ATP-sensitive potassium (KATP) channel. The aim present study was compare genotype specific effect gliclazide binding KATP channel A-site (Group 1) with AB-site 2). A total 101 patients were treated for 6 months as an add-on therapy previous metformin treatment. rs7903146 C/T identified real-time PCR subsequent melting...
Objective(s) High variability in clinical response to metformin is often observed type 2 diabetes (T2D) patients, and it highlights the need for identification of genetic components affecting efficiency therapy. Aim this observational study evaluate role tagSNPs (tagging single nucleotide polymorphisms) from genomic regions coding six transporter genes with respect short-term efficiency. Design 102 6 transporters were genotyped group T2D patients treated 3 months. Methods Most significant...
Aim: We examined associations of eight SNPs in/near seven candidate genes with glycemic response to 6 month treatment DPP4 inhibitors. Patients & methods: 206 patients type 2 diabetes (116 men and 90 women) were treated sitagliptin or vildagliptin (both 100 mg/day) in combination metformin metformin/sulphonylurea over months, the reduction glycated hemoglobin (HbA1c) was measured. Results: Rs6923761 GLP1R significantly associated a HbA1c (adjusted p = 0.006). Homozygotes for minor A allele...
Aim of this study was to evaluate the effect vitamin D supplementation in obese, insulin resistant and deficient PCOS women on biochemical clinical hyperandrogenism menstrual irregularity comparison metformin or combined plus therapy. Thirty nine were randomized into three groups treated with alfacalcidiol (Group 1), therapy 2) 3) for 6 months. Serum TST, fTST, DHEAS, LH LH/FSH measured before after six months treatment. Menstrual cycle regularity, hirsutism, acne pregnancy rate assessed at...
The aim of the present pilot pharmacogenetic study was to analyse quantitative effects sulphonylurea treatment in addition metformin on parameters glycemic control with respect CDKAL1 genotypes patients type 2 diabetes. Effect 6-month therapy according evaluated 101 diabetes who failed achieve monotherapy. rs7756992 polymorphism determined by melting curve analysis small amplicon following real-time PCR. After fasting plasma glucose (FPG) levels were significantly different (p=0.045) among...
There is increasing evidence that intermittent hypoxia resulting from obstructive sleep apnoea (OSA) independently associated with dyslipidaemia. Currently, no data exist on potential links between OSA-related dyslipidaemia and susceptibility genes for in such patients. Our aim was to study the effects of apolipoprotein E (<i>APOE</i>) genotype severity atherogenic patients OSA. 519 clinically stable subjects prospectively recruited at a tertiary referral teaching hospital underwent full...
Abstract Background: The aim of this randomized clinical trial (RCT) was to evaluate the effect vitamin D supplementation in obese, insulin-resistant (IR) and D-deficient polycystic ovary syndrome (PCOS) women on metabolic abnormalities comparison metformin or combined plus therapy. Material methods: Thirty-nine PCOS who fulfilled inclusion criteria were into three groups treated with alfacalcidiol, alfacalcidiol therapy for 6 months. Body weight, body mass index (BMI), waist circumference,...
Cardiovascular diseases are among the leading causes of morbidity and mortality, particularly in individuals with type 2 diabetes. There is a need for new biomarkers to improve prediction cardiovascular events overall mortality. We investigated association selected atherosclerosis related biomarkers, specifically osteoprotegerin (OPG), 25-hydroxy-vitamin D (25(OH)D), C-reactive protein (CRP), lipopolysaccharide-binding (LBP), asymmetric dimethylarginine (ADMA), occurrence any event or...