A5039730007- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Obstructive Sleep Apnea Research
- Adipokines, Inflammation, and Metabolic Diseases
- Long-Term Effects of COVID-19
- Neuroscience of respiration and sleep
- Sleep and related disorders
- Respiratory and Cough-Related Research
- Asthma and respiratory diseases
- Heart Rate Variability and Autonomic Control
- Bone health and osteoporosis research
- Cardiovascular and Diving-Related Complications
- Mechanical Circulatory Support Devices
- COVID-19 Clinical Research Studies
- Airway Management and Intubation Techniques
- Nutrition and Health in Aging
- Biomarkers in Disease Mechanisms
- Bone Metabolism and Diseases
- Protease and Inhibitor Mechanisms
- Adipose Tissue and Metabolism
- Peptidase Inhibition and Analysis
- COVID-19 and Mental Health
- Sleep and Wakefulness Research
- Neonatal Respiratory Health Research
- Cerebrospinal fluid and hydrocephalus
University of Pavol Jozef Šafárik
2016-2025
Univerzitná Nemocnica Louisa Pasteura
2016
Detská Fakultná Nemocnica s Poliklinikou
2010
Abstract Rationale Persistent respiratory symptoms following Coronavirus Disease 2019 (COVID-19) are associated with residual radiological changes in lung parenchyma, a risk of development into fibrosis, and impaired pulmonary function. Previous studies hinted at the possible efficacy corticosteroids (CS) facilitating resolution post-COVID lungs, but available data is limited. Aim To evaluate effects CS treatment syndrome patients. Patients methods Post-COVID patients were recruited...
Potential links between metabolic derangements and adipose tissue (AT) inflammation in patients with chronic obstructive pulmonary disease (COPD) are unexplored. We investigated AT expressions of interleukin (IL)-6, tumor necrosis factor (TNF)-α, CD68 (macrophage cell surface receptor), caspase-3, Bax, their relationships to the phenotype nine cachectic, 12 normal-weight, overweight, 11 obese COPD (age<mml:math...
<i>Background:</i> CD40, a transmembrane receptor of the tumor necrosis factor gene superfamily, is activated in response to cellular stress, including hypoxia, and orchestrates process inflammation via secondary messengers such as mitogen-activated protein kinase 4 (MKK4) c-Jun NH<sub>2</sub>-terminal kinases (JNK). <i>Objectives:</i> We hypothesized that MKK4 JNK expression increased adipose tissue patients with very severe chronic obstructive pulmonary...
Increases in resting energy expenditure (REE) likely contribute to weight loss various chronic diseases. In obstructive pulmonary disease (COPD), relationships between the ventilatory impairment and increased REE, disturbances adipokines were previously described. Therefore, we investigated serum levels adipose tissue expression of leptin adiponectin, their REE patients with COPD. 44 stable COPD (38 male; age 62.3+/-7.2 years), was assessed using indirect calorimetry. Subcutaneous samples...
Obstructive sleep apnoea (OSA) has been associated with disturbances in energy metabolism and insulin resistance, nevertheless, the links between OSA severity, resting expenditure (REE) resistance (homeostasis model assessment, HOMA-IR) remained unexplored. Therefore, we investigated effects of severity on REE, relationships REE HOMA-IR patients OSA. Forty men [mean (SD) age 49.4 (11.4) years] underwent overnight polysomnography; was assessed using indirect calorimetry. adjusted for fat-free...
Obstructive sleep apnea (OSA) is associated with dyslipidemia and increased cardiovascular risk. We assessed the effects of apolipoprotein E ( APOE) genotype on low-density lipoprotein (LDL) high-density (HDL) particle size lipid subclasses (separated by gradient gel electrophoresis) in patients OSA. Stable (n = 181) prospectively recruited underwent full polysomnography. Both LDL I proportion were reduced from ∊3∊3 homozygotes to ∊2 carriers ∊4 (analysis variance: P .024; .040,...
Severe respiratory failure is one of the most serious complications coronavirus disease 2019 (COVID-19). In a small proportion patients, mechanical ventilation fails to provide adequate oxygenation and extracorporeal membrane (ECMO) needed. The surviving individuals need long-term follow-up as it not clear what their prognosis is.To complex clinical picture patients during exceeding year after ECMO therapy due severe COVID-19.All subjects involved in study required acute stage COVID-19....
In this review, early career and senior members of Assembly 5 (Airway Diseases, Asthma, COPD Chronic Cough) present key recent findings pertinent to airway diseases that were presented during the European Respiratory Society International Congress 2023 in Milan, Italy, with a particular focus on asthma, COPD, chronic cough bronchiectasis. During congress, an increased number symposia, workshops abstract presentations organised. total, 739 abstracts submitted for majority these by members....
The study analysed post-acute COVID-19 symptoms and the pulmonary function test (PFT) results in patients surviving native strain of virus.The was prospective; inclusion criteria were positive PCR for SARS-CoV-2 age 18-100. Exclusion active respiratory infection, known or suspicious pre-existing disease, cardiac failure, recent acute embolism, anaemia, neuromuscular diseases. recruitment period 1st March 2020 - 25th December 2020. initial examination performed 4-12 weeks after disease onset....
Non-invasive positive pressure ventilation (NIPPV) is increasingly used as a treatment method for patients with respiratory failure. The first recommendations the use of NIPPV in Slovakia were developed by Slovak Society Pulmonology and Phthisiology 2007 partially revised 2015. New scientific evidence prompted present update, which based on widely accepted international guidelines was adapted to address local needs. Important features update include classification acute indications into...
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