Judith Bruchfeld
A5030569559- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Long-Term Effects of COVID-19
- Pneumocystis jirovecii pneumonia detection and treatment
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Antibiotics Pharmacokinetics and Efficacy
- Cardiovascular Syncope and Autonomic Disorders
- Heart Rate Variability and Autonomic Control
- COVID-19 and Mental Health
- Intensive Care Unit Cognitive Disorders
- Biosimilars and Bioanalytical Methods
- Antibiotic Resistance in Bacteria
- Respiratory Support and Mechanisms
- HIV/AIDS drug development and treatment
- Drug-Induced Adverse Reactions
- Rheumatoid Arthritis Research and Therapies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmacovigilance and Adverse Drug Reactions
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pain Management and Treatment
- Apelin-related biomedical research
- Pharmaceutical studies and practices
Karolinska University Hospital
2016-2025
Karolinska Institutet
2016-2025
Biology of Infection
2022
National Health Service
2020
Feinstein Institute for Medical Research
2014-2016
University Hospital of Lausanne
2015
Armauer Hansen Research Institute
2012
Makerere University
2012
Stellenbosch University
2012
Stockholm University College of Music Education
2001-2003
Large studies on bedaquiline used to treat multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB) are lacking. This study aimed evaluate the safety effectiveness of bedaquiline-containing regimens in a large, retrospective, observational conducted 25 centres 15 countries five continents.428 culture-confirmed MDR-TB cases were analysed (61.5% male; 22.1% HIV-positive, 45.6% XDR-TB). admitted hospital for median (interquartile range (IQR)) 179 (92-280) days exposed 168...
In the absence of active tuberculosis, a positive tuberculin skin test (TST) or interferon-γ release assay (IGRA) result defines latent infection with Mycobacterium although results may vary depending on immunodeficiency.This study compared performance TST and IGRAs in five different groups immunocompromised patients, evaluated their ability to identify those at risk for development tuberculosis.Immunocompromised patients HIV infection, chronic renal failure, rheumatoid arthritis,...
Major clinical centers in Sweden have witnessed an inflow of patients with chronic symptoms following initial outpatient care for coronavirus disease-2019 (COVID-19) infection, suggestive postural orthostatic tachycardia syndrome. This report presents the first case series 3 Swedish diagnosed syndrome more than months after primary COVID-2019 infections. (Level Difficulty: Intermediate.)
The World Health Organization (WHO) recommends that countries implement pharmacovigilance and collect information on active drug safety monitoring (aDSM) management of adverse events.The aim this prospective study was to evaluate the frequency severity events anti-tuberculosis (TB) drugs in a cohort consecutive TB patients treated with new (i.e. bedaquiline, delamanid) repurposed clofazimine, linezolid) drugs, based WHO aDSM project. Adverse were collected prospectively after attribution...
Objective To estimate the risk of tuberculosis (TB) in patients with rheumatoid arthritis (RA) both and without exposure to biological therapy directly compare risks between therapies. Methods Data from Swedish National Population Registers, Tuberculosis Register Biologics were used conduct a prospective population-based national cohort study (2002–2011). We estimated rate incident TB general population biological-naïve biological-exposed diagnosed RA. Cox models HRs particular attention by...
Abstract Background The occurrence and healthcare use trajectory of post COVID‐19 condition (PCC) is poorly understood. Our aim was to investigate these aspects in SARS‐CoV‐2‐positive individuals with without a PCC diagnosis. Methods We conducted population‐based cohort study adults Stockholm, Sweden, verified infection from 1 March 2020 31 July 2021, stratified by the severity acute infection. outcome diagnosis registered any time 90–360 days after positive test. performed Cox regression...
Background. Childhood tuberculosis (TB) is difficult to diagnose reliably because signs and symptoms are nonspecific sputum for direct microscopy obtain, especially in very young children. This diagnostic dilemma thought have increased with the HIV pandemic. Few studies on treatment outcome of dually infected children high endemic countries been reported. study examines impact infection clinical presentation, criteria TB Ethiopian Methods. A prospective cohort diagnosed Addis Ababa from...
ABSTRACT We have identified a clonal complex of Mycobacterium bovis isolated at high frequency from cattle in Uganda, Burundi, Tanzania, and Ethiopia. named this related group M. strains the African 2 (Af2) bovis. Af2 are defined by specific chromosomal deletion (RDAf2) can be absence spacers 3 to 7 their spoligotype patterns. Deletion analysis isolates Algeria, Mali, Chad, Nigeria, Cameroon, South Africa, Mozambique did not identify any complex, suggesting that is localized East Africa. The...
Rationale Studies investigating the risk of active tuberculosis (TB) in association with pregnancy have not been conclusive. We aimed to investigate this a large retrospective register-based cohort study Sweden. Methods Data from women 15–49 years age who had given birth Sweden between 2005 and 2013 were extracted national childbirth register linked TB register. Cohort time was divided into three exposure periods: during pregnancy, six months (180 days) postpartum neither pregnant nor...
The World Health Organization (WHO) recommends countries introduce new anti-TB drugs in the treatment of multidrug-resistant tuberculosis. aim study is to prospectively evaluate effectiveness bedaquiline (and/or delamanid)- containing regimens a large cohort consecutive TB patients treated globally. This observational, prospective based on data collected and provided by Global Tuberculosis Network (GTN) centres analysed twice year. All (including children/adolescents) with and/or delamanid...
To evaluate the access to comprehensive diagnostics and novel antituberculosis medicines in European countries.
Abstract Background With ~ 50 million individuals suffering from post-COVID condition (PCC), low health related quality of life (HRQoL) is a vast problem. Common symptoms PCC, that persists 3 months the onset COVID-19 are fatigue, shortness breath and cognitive dysfunction. No effective treatment options have been widely adopted in clinical practice. Hyperbaric oxygen (HBO 2 ) candidate drug. Methods The objective this interim analysis to describe our cohort evaluate safety HBO for post...
Adverse effects (AE) to TB treatment cause morbidity, mortality and interruption. The aim of these clinical standards is encourage best practise for the diagnosis management AE.
We have previously developed a diagnostic test for tuberculosis based on detection of mycobacterial lipoarabinomannan (LAM) in urine. The method depended laborious concentration step. now an easy to perform magnetic immunoassay platform, utilizing high avidity monoclonal antibodies the LAM With this analytical sensitivity assay was increased 50-100-fold compared conventional ELISA. In pilot study HIV-negative patients with microbiologically verified TB (n=17) and healthy controls (n=22) 82%...