A5056150399- Tuberculosis Research and Epidemiology
- Immune Cell Function and Interaction
- Mycobacterium research and diagnosis
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Bone health and osteoporosis research
- bioluminescence and chemiluminescence research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Infectious Diseases and Tuberculosis
- Hip and Femur Fractures
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune cells in cancer
- Bladder and Urothelial Cancer Treatments
- Wildlife Ecology and Conservation
- Bone health and treatments
- Pneumonia and Respiratory Infections
- Inflammatory mediators and NSAID effects
- Asthma and respiratory diseases
- Monoclonal and Polyclonal Antibodies Research
- Diagnosis and treatment of tuberculosis
- HIV Research and Treatment
- COVID-19 Clinical Research Studies
- Health Systems, Economic Evaluations, Quality of Life
University of Southern Denmark
2016-2025
Mendel University in Brno
2009-2025
University of Göttingen
2023
Mercedes-Benz (Germany)
2022
BASF (Germany)
2022
Odense University Hospital
2018-2021
Research Center Borstel - Leibniz Lung Center
2008-2018
Dietrich Bonhoeffer Klinikum
2016
Institute for Exercise and Environmental Medicine
2015
German Center for Infection Research
2014
We describe a new cellular component of normal mouse thymuses, which is isolated by fractionated trypsin dissociation minced thymus tissue followed repeated unit gravity sedimentation. These cells are unusually large size, with diameters 30 mum and more. They represent complexes single filled high numbers lymphoid cells. The majority the engulfed not only fully intact, as judged morphological criteria, but, moreover, includes proportion mitotic figures. Electron microscopic investigations...
Population-level knowledge on individuals at high risk of severe and fatal coronavirus disease 2019 (COVID-19) is urgently needed to inform targeted protection strategies in the general population.We examined characteristics predictors hospitalization death a nationwide cohort all Danish tested for acute respiratory syndrome 2 (SARS-CoV-2) from 27 February 2020 until 19 May 2020.We identified 11 122 SARS-CoV-2 polymerase chain reaction-positive cases whom 80% were community-managed 20%...
In the absence of active tuberculosis, a positive tuberculin skin test (TST) or interferon-γ release assay (IGRA) result defines latent infection with Mycobacterium although results may vary depending on immunodeficiency.This study compared performance TST and IGRAs in five different groups immunocompromised patients, evaluated their ability to identify those at risk for development tuberculosis.Immunocompromised patients HIV infection, chronic renal failure, rheumatoid arthritis,...
Abstract Aims To investigate the putative association between semaglutide and non‐arteritic anterior ischaemic optic neuropathy (NAION). Materials Methods Data from national health registries in Denmark (2018–2024) Norway (2018–2022) were used to compare NAION risk individuals with type 2 diabetes initiating versus sodium‐glucose co‐transporter inhibitors (SGLT‐2is). A supplementary self‐controlled analysis examined among all users. National estimates pooled using a fixed‐effects model....
In recent years the number of reports describing phenotypically and functionally distinct subsets human blood leukocytes, in particular subtypes antigen-presenting cells has continuously increased. A great diversity was described not only for dendritic (DC), but also monocytes (Mo) macrophages (Mac). Similar to DC, different types Mo could be defined by phenotypes immunoregulatory functions. The characterization subpopulations revealed that some them exhibit common features with myeloid or...
SUMMARY Apart from the diagnostic value of anti-neutrophil cytoplasmic antibodies (ANCA), their detailed characterisation and that corresponding antigens have opened new ways for exploration pathogenesis primary systemic vasculitis. ANCA arc now thought to play an important functional role via activation phagocytic cells (e.g. polymorphonuclear neutrophils (PMN)). In this study we examined mechanisms by which could gain access proteinase 3 (PR3) in intact PMN, at two levels: ex vivo...
Abstract More than 150 million humans in tropical countries are infected by filarial nematodes which harbor intracellular bacterial endosymbionts of the genus Wolbachia (Rickettsiales). These bacteria have been implicated adverse effects drug treatment filariasis. The present study provides evidence that purified major surface protein (rWSP) acts as an inducer innate immune system through TLR2 and TLR4: 1) recombinant, stringently rWSP elicited release TNF-α, IL-12, IL-8 from cultured blood...
Short β-peptides can mimic natural peptide hormones, as has been shown with a cyclo-β-tetrapeptide (1) that displays micromolar affinity to human somatostatin receptors. β-Peptides are thus promising new class of peptidomimetics potential high bioavailability due their excellent resistance against proteases.
In infection experiments with genetically distinct Mycobacterium tuberculosis complex (MTBC) strains, we identified clade-specific virulence patterns in human primary macrophages and mice infected by the aerosol route, both reflecting relevant model systems. Exclusively human-adapted M. lineages, also termed clade I, comprising "modern" such as Beijing Euro-American Haarlem showed a significantly enhanced capability to grow compared that of II which include "ancient" as, e.g., East African...
The diagnosis of pleural tuberculosis (plTB) by the analysis effusions (PEs) with standard diagnostic tools is difficult. In routine clinical practice, present authors evaluated performance a commercially available Mycobacterium (MTB)-specific enzyme-linked immunospot assay on peripheral blood mononuclear cells (PBMCs) and effusion (PEMCs) in patients suspect plTB. T-SPOT. TB test (Oxford Immunotec Ltd, Abingdon, UK) was performed PBMCs PEMCs 20 radiological plTB 21 control subjects PE...
Statin use is common in older persons. Given uncertainties ongoing benefit, changes health status, and shifting goals of care preferences, statin discontinuation may be considered some persons, although there currently little evidence to guide this decision.
The use of tramadol and other opioids for pain management has been accompanied by a multitude challenges concerns worldwide. saw decline in Denmark during 2017–2019 slight increase the morphine oxycodone. Using Danish National Prescription Registry utilizing data until including 2023, we aimed to provide updated on utilization patterns Denmark. We found 35% from 2017 2023 most likely due media attention, regulatory actions, health campaigns targeted education physicians patients authorities....
Abstract Aim This study aims to conduct a hypothesis‐generating screening for acute cardiovascular effects of prescription medications. Methods Danish nationwide was conducted among incident cases diseases, including myocardial infarction (MI), ischemic stroke (IS), heart failure (HF), venous thromboembolism (VTE), myocarditis, and atrial fibrillation (AF), between January 2000 December 2022. Using case‐crossover design, we examined exposure individual drugs on the date event (focal date)...
In a large proportion of patients with active pulmonary tuberculosis (pTB), acid-fast bacilli smear results for sputum and bronchial secretions are negative. Detectable growth Mycobacterium (MTB) in cultures takes several weeks MTB-specific DNA amplification on variable these patients.We investigated whether rapid diagnosis pTB can be established by enumeration mononuclear cells from bronchoalveolar lavage (BAL) fluid routine clinical practice.Patients presenting to tertiary hospital medical...
Human monocytes (Mo) consist of a major subset Fcgamma-receptor I (CD64)-positive typical low accessory phagocytes, and minor CD64(-) DC-like with high T cell-accessory IFN-alpha-releasing activity. Both populations also differentially express CD16 (Fcgamma-receptor III). Double labeling anti-CD64 anti-CD16 mAb, as performed here, identified four different subsets. The consists / 16(+) cells antigen-presenting cell (APC) function macrophage-like phenotype, 16(-) less active APC but which...
The interaction of CD28 with its ligands is important for T-cell activation. Recent studies demonstrated the existence at least two on accessory cells, CD80 (B7-1) and CD86 (B7-2). In this study we demonstrate that, although are both expressed monocytes, they seem to have different functions. Freshly isolated monocytes express but CD80-negative. expression weakly induced after 6-8 hr in vitro culture enhanced by stimulation. faster than reaches peak level 4-6 stimulated cells. Reverse...
Rationale: The rapid diagnosis of pulmonary tuberculosis (TB) is difficult when acid fast bacilli (AFB) cannot be detected in sputum smears.Objectives: Following a proof principle study, we examined routine clinical practice whether individuals with AFB smear-negative TB can discriminated from those latent infection by local immunodiagnosis Mycobacterium tuberculosis–specific enzyme-linked immunospot (ELISpot) assay.Methods: Subjects suspected having active who were unable to produce or...
Kupffer cells were isolated from pronase‐perfused rat livers and maintained as a monolayer culture in state of high purity viability. Immediately after contact with zymosan particles, O 2 uptake the increased fivefold; about 50% net oxygen consumed was accounted for superoxide released into medium. Concomitantly, transient burst luminol‐dependent chemiluminescence, an activity NAD(P)H oxidase stimulation flow glucose through hexose monophophate shunt observed. Chemiluminescence production...
Bacterial infections are known to cause severe health-threatening conditions, including sepsis. All attempts get this disease under control failed in the past, and especially times of increasing antibiotic resistance, leads one most urgent medical challenges our times. We designed a peptide bind with high affinity endotoxins, potent pathogenicity factors involved triggering The Pep19-2.5 reveals endotoxin neutralization efficiency vitro, here, we demonstrate its antiseptic/anti-inflammatory...
Abstract Objective To perform an expedited assessment of cancer risk associated with exposure to N-nitrosodimethylamine (NDMA) through contaminated valsartan products. Design Nationwide cohort study. Setting Danish health registries on individual level prescription drug use, occurrence, and hospital diagnoses. Participants 5150 patients no history cancer, aged 40 years or older, using at 1 January 2012 initiating use between 30 June 2017. were followed from one year after entry (lag time...