A5077338110- Vector-borne infectious diseases
- Parasites and Host Interactions
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Pneumocystis jirovecii pneumonia detection and treatment
- Parasite Biology and Host Interactions
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Multiple Sclerosis Research Studies
- Clostridium difficile and Clostridium perfringens research
- Malaria Research and Control
- Liver Disease and Transplantation
- HIV/AIDS drug development and treatment
- Antimicrobial Resistance in Staphylococcus
- Travel-related health issues
- Respiratory viral infections research
- Insect and Pesticide Research
- Antifungal resistance and susceptibility
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- Infective Endocarditis Diagnosis and Management
- Microscopic Colitis
- Immunodeficiency and Autoimmune Disorders
- Research on Leishmaniasis Studies
University of Rostock
2016-2025
Universitätsmedizin Rostock
2013-2024
Universidad Autónoma de Madrid
2024
Universitätsmedizin Greifswald
2022
Genomic (Brazil)
2022
Charles University
2022
University Medical Center
2016-2022
University of Prishtina
2019
Bernhard Nocht Institute for Tropical Medicine
1989-2019
University Clinical Center of Kosovo
2019
Vector-based SARS-CoV-2 vaccines have been associated with vaccine- induced thrombosis thrombocytopenia syndrome (VITT/TTS), but the causative factors are still unresolved. We comprehensively analyzed ChAdOx1 nCoV-19 (AstraZeneca) and Ad26.COV2.S (Johnson Johnson) vaccines. contains significant amounts of host cell protein impurities, including functionally active proteasomes, adenoviral proteins. A much smaller amount impurities was found in Ad26.COV2.S. Platelet factor 4 formed complexes...
Summary Aims To evaluate the immunogenicity and safety of a seasonal influenza vaccine in cohort multiple sclerosis (MS) patients receiving different immunomodulating/immunosuppressive therapies assess predictors immune response. Methods A prospective, multicenter, non‐randomized observational study including 108 trivalent vaccination was conducted. Influenza‐specific antibody titers (H1N1, H3N2, B) were measured to rates seroprotection seroconversion/significant titer increase. Univariable...
Fever tends to start at a lower level of parasitemia in Plasmodium vivax or ovale than P. falciparum malaria, but hyperparasitemia and complications are more likely occur malaria. Therefore, we compared the relationship between host response parameters before therapy 97 patients with faciparum malaria (18 complications), 28 malaria.In both types correlated blood levels tumour necrosis factor alpha (TNF-alpha), lactate dehydrogenase (LDH), Thrombin-antithrombin III (TAT) elastase, these were...
Albumin is an important transport protein for non-water-soluble protein-bound drugs and uraemic toxins. Its capacity reduced in patients with advanced chronic kidney disease (CKD) unbound fractions of toxins are related to complications CKD. We investigated whether this reduction could be quantified how it correlated the stages Albumin-binding (ABiC) a dye-based method that quantifies remaining binding one major site (site II) albumin molecule.Blood samples from 104 CKD were incubated...
Abstract Background. Antibiotic-associated diarrhea (AAD) and Clostridium difficile-associated (CDAD) are common complications of antibiotic use. Data on the efficacy probiotics to prevent AAD CDAD unclear. We aimed evaluate Saccharomyces boulardii in hospitalized adult patients. Methods. conducted a multicenter, phase III, double-masked, randomized, placebo-controlled trial patients who received systemic treatment 15 hospitals Germany between July 2010 October 2012. Participants Perenterol...
Intrahepatic granuloma formation and fibrosis characterize the pathological features of Schistosoma mansoni infection. Based on previously observed substantial anti-fibrotic effects 24-nor-ursodeoxycholic acid (norUDCA) in Abcb4/Mdr2(-/-) mice with cholestatic liver injury biliary fibrosis, we hypothesized that norUDCA improves inflammation-driven S. infection.Adult NMRI were infected 50 cercariae after 12 weeks received either norUDCA- or ursodeoxycholic (UDCA)-enriched diet (0.5% wt/wt)...
Abstract Background While vaccination programs against the severe acute respiratory syndrome virus 2 (SARS-CoV-2) are globally ongoing, disparate strategies for deployment of spike antigen show varying effectiveness. Methods In order to explore this phenomenon, we sought compare early immune responses AZD1222 and BNT162b2. SARS-CoV-2 seronegative participants received a single dose either vaccine were analyzed cell, effector T antibody dynamics. Results induced transient leukopenia major...
To quantitatively assess the role of Candida species in antibiotic-associated diarrhea (AAD), stool samples from a total 395 patients and control subjects were cultured differential isolation medium: 98 had AAD, 93 taking antibiotics but did not have (A+D−), 97 (A−D+), 107 (A−D−). In addition, secreted aspartyl proteinase (Sap) production was tested. AAD patients, positivity (77/98) overgrowth (62/98) different that among A+D− (75/93 [P=.860] 52/93 [P=.375], respectively). A−D+ (40/97,...
The objective of the present study was to establish a system real-time polymerase chain reactions (PCRs) for specific detection Yersinia pestis using LightCycler (LC) instrument. Twenty-five strains Y. pestis, 94 other species and 33 clinically relevant bacteria were investigated. Assays 16S rRNA gene target plasminogen activator (resides on 9.5-kb plasmid) murine toxin fraction 1 antigen (both 100-kb combined use in two multiplex assays including an internal amplification control detecting...
The optimal management of inoperable desmoid tumors is still unclear. We report a 26 year-old female patient with familial adenomatous polyposis suffering from recurrent intraabdominal tumor and its sequential treatment.Treatment strategies included low-dose tamoxifen (30 mg orally per day), high-dose (90 subsequent combination goserelin acetate (3.6 subcutaneously once every four weeks) plus tamoxifen, medroxyprogesterone (1000 day) interferon gamma (3 Mio IU 3 times week).The resulted in...
Reisinger, Emil C.; Vogetseder, Werner; Berzow, Dirk; Köfler, Dieter; Bitterlich, Gabriele; Lehr, Hans A.†; Wachter, Helmut*; Dierich, Manfred P. Author Information
Organ failure in Plasmodium falciparum malaria is associated with neutrophil activation and endothelial damage. This study investigates whether neutrophil-induced damage involves apoptosis it can be prevented by neutralization of secretory products. Endothelial cells from human umbilical veins were coincubated neutrophils healthy donors sera eight patients P. malaria, three vivax controls. was demonstrated terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL)...