A5029561674- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Inflammatory Bowel Disease
- Digestive system and related health
- Microscopic Colitis
- Liver Diseases and Immunity
- Viral-associated cancers and disorders
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- RNA Research and Splicing
- Autoimmune and Inflammatory Disorders
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and disorders
- Lysosomal Storage Disorders Research
- Diet, Metabolism, and Disease
- Galectins and Cancer Biology
- Pancreatitis Pathology and Treatment
Hospital Base
2025
Clínica Las Condes
2018-2025
Hospital Clínico de la Universidad de Chile
2017-2025
Center for Rheumatology
2024
Pontificia Universidad Católica de Chile
2007-2023
Advanced Center for Chronic Diseases
2017-2022
University of Chile
2015-2020
Anthrologica
2020
Icahn School of Medicine at Mount Sinai
2013-2017
Miller Orthopedic Specialist
2017
Abstract Background Multiple aberrant microRNA expression has been reported in gastric cancer. Among them, microRNA-335-5p (miR-335), a regulated by DNA methylation, to possess both tumor suppressor and promoter activities. Results Herein, we show that miR-335 levels are reduced cancer significantly associate with lymph node metastasis, depth of invasion, ultimately poor patient survival cohort Amerindian/Hispanic patients. In two cell lines AGS and, Hs 746T the exogenous decreases...
Niemann-Pick type C disease (NPC) is a neurovisceral lipid storage disorder mainly characterized by unesterified cholesterol accumulation in lysosomal/late endosomal compartments, although there also an important for several other kind of lipids. The main tissues affected the are liver and cerebellum. Oxidative stress has been described various NPC cells tissues, such as Although considerable alterations occur liver, pathological mechanisms involved hepatocyte damage death have not clearly...
Abstract Background The enzyme 11β‐hydroxysteroid‐dehydrogenase type 1 (11β‐ HSD 1) catalyses the reactivation of intracellular cortisol. We explored potential role 11β‐ overexpression in visceral adipose tissue ( VAT ) non‐alcoholic fatty liver disease NAFLD assessing sequential changes expression, hepatic and tissue, occurrence portal hypercortisolism obese mice. expression was also assessed tissues from patients undergoing bariatric surgery. Methods Peripheral corticosterone levels...
Chronic gastritis is an inflammation of the gastric mucosa and has multiple etiologies. Here we discuss pathological alterations induced by Helicobacter pylori (HP) leading to chronic epigenetic bases underlying these changes. We review histology normal overview role HP in multistep cascade GC. attempt define Operative Link for Gastritis Assessment (OLGA) staging system assessing risk The gastritis, mainly DNA methylation, are presented through examples such as (i) methylation promoter...
Abstract Neutrophils are the most abundant cell type in immune system and play an important role innate response. Using a diverse range of mouse models with either defective dendritic (DC) development or conditional DC depletion, we provide vivo evidence indicating that conventional DCs regulation neutrophil homeostasis. Flk2, Flt3L, Batf3 knockout mice, which have defects development, increased numbers liver neutrophils steady state. Conversely, frequency is reduced DC-specific PTEN...
Reprimo (RPRM), a downstream effector of p53-induced cell cycle arrest at G2/M, has been proposed as putative tumor suppressor gene (TSG) and potential biomarker for non-invasive detection gastric cancer (GC). The aim this study was to evaluate the epigenetic silencing RPRM by promoter methylation its function in GC lines. Furthermore, clinical significance protein product association with p53/p73 family explored. Epigenetic evaluated four Protein expression 20 non-tumor matched cases....
Hospital-acquired infections by multidrug-resistant Gram-negative bacteria (MDRGN) have become a global public health problem. Colistin is considered one of the last therapeutic options due to its limited clinical effectiveness and high rate adverse effects. Unfortunately, use has increase in recent years given MDRGN-associated narrow alternatives. With aim improving using pharmacokinetic/pharmacodynamic knowledge, higher doses colistin been used but with few reported outcomes. A...
Helicobacter pylori infects the human stomach and modifies signaling pathways that affect gastric epithelial cell proliferation viability. Chronic exposure to this pathogen contributes onset of atrophy, an early event in genesis cancer associated with H. infection. Susceptibility pylori- induced death ultimately depends on presence protective host factors. Although expression inhibitor-of-apoptosis protein survivin adults is frequently linked development cancer, evidence indicating present...
Background: Somatotropic axis dysfunction associated with non-alcoholic fatty liver disease (NAFLD) has potential multisystemic detrimental effects. Here, we analysed the effects of growth hormone (GH) and insulin-like factor-1 (IGF-1) supplementation on histology, adipokine profile muscle function in an NAFLD model. Methods: C57BL/6 mice were fed a high fat diet (HFD) for 12 weeks separated into three groups treated 4 with: (1) High (n = 10); (2) HFD + GH 9 μg/g/d (3) IGF-1 0.02 µg/g/d 9)....
Histologic assessment of high-risk gastritis for the development gastric cancer is not well defined. The identification tissue markers together with integration histologic features will be required this assessment.Matched tumor/nontumor adjacent mucosa (NTAM) 91 early and 148 chronic cases were evaluated characteristics (atrophy, intestinal metaplasia, inflammation, polymorphonuclear infiltration, Helicobacter pylori) by Sydney System. Atrophy risk was also Operative Link on Gastritis...
Reprimo-like (RPRML) is an uncharacterized member of the Reprimo gene family. Here, we evaluated role RPRML and whether its regulation by DNA methylation a potential non-invasive biomarker gastric cancer. expression was immunohistochemistry in 90 patients with cancer associated clinicopathologic characteristics outcomes. The biology investigated vitro, through ectopic overexpression. Functional experiments included colony formation, soft agar, MTS, Ki67 immunofluorescence assays....
Background. The plasminogen activator inhibitor type-1 (PAI-1) has been implicated in the regulation of fibrinolysis and extracellular matrix components. single base pair guanine insertion/deletion polymorphism (4G/5G) within promoter region PAI-1 gene influences synthesis may modulate hepatic fibrogenesis. Aim. To evaluate influence serum levels 4G/5G on risk liver fibrosis associated to non-alcoholic fatty disease (NAFLD) morbidly obese patients. Material methods. Case-control study 50...
Liver biopsy diagnosis of primary sclerosing cholangitis (PSC) is difficult. We performed a detailed histologic analysis PSC cases using novel bioinformatics to identify features that may be useful in its diagnosis.PSC liver explants were examined and compared with biliary cirrhosis hepatitis C act as controls. Demographic, macroscopic, variables analyzed both conventional statistics an integrative approach, significance microarrays (SAM), hierarchical clustering (HCA).The group was younger...
Reprimo (RPRM), a member of the RPRM gene family, is tumor-suppressor involved in regulation p53-mediated cell cycle arrest at G2/M. has been associated with malignant tumor progression and proposed as potential biomarker for early cancer detection. However, expression role RPRM, well its are poorly understood their physiology yet unstudied. In this scenario, model system like zebrafish could serve to dissect family members vivo. Phylogenetic analysis reveals that RPRML have differentially...
Gallbladder cancer (GBC) is one of the deadliest malignancy and treatment options are deplorably limited. Better strategies prevention urgently needed but knowledge on risk factors remains scarce. Recent data suggested that arsenic (As) may be involved in GBC carcinogenesis question debated. To date, there no As measurement samples. This pilot study aimed to measure concentrations tissue samples from patients with compared non-cancerous gallbladder (NCGB). Included underwent cholecystectomy...