A5077829069- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Galectins and Cancer Biology
- Veterinary medicine and infectious diseases
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Salmonella and Campylobacter epidemiology
- Gut microbiota and health
- Viral gastroenteritis research and epidemiology
- Microbial Metabolites in Food Biotechnology
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal motility and disorders
- Celiac Disease Research and Management
- Escherichia coli research studies
- Microscopic Colitis
- Dermatology and Skin Diseases
- Mycobacterium research and diagnosis
- Diet and metabolism studies
- Colorectal Cancer Screening and Detection
- Bacteriophages and microbial interactions
- Glycosylation and Glycoproteins Research
- IL-33, ST2, and ILC Pathways
- Digestive system and related health
- Diet, Metabolism, and Disease
NYU Langone Health
2014-2024
New York University
2013-2024
University of Alabama at Birmingham
1996-2022
Hinge Health
2022
University of Chile
2021
Instituto de Salud Carlos III
2016
University of Nicosia
2016
Hospital Universitario de La Princesa
2016
Hospital Infantil Universitario Niño Jesús
2016
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2016
Helicobacter pylori are gram-negative spiral bacteria that associated with chronic gastritis, a known precursor of gastric carcinoma. Persons at high risk for carcinoma have been shown to prevalence H. infection.
A longitudinal study of intestinal microbiota in children and their mothers shows that antibiotics, cesarean section, infant formula alter patterns microbial acquisition succession during the first 2 years childhood.
The microbiota of the human stomach and influence Helicobacter pylori colonization on its composition remain largely unknown. We characterized bacterial diversity within gastric mucosa by using a small subunit 16S rDNA clone library approach analyzed 1,833 sequences generated broad-range PCR from 23 endoscopic biopsy samples. A diverse community 128 phylotypes was identified, featuring at this site greater than previously described. majority were assigned to Proteobacteria , Firmicutes...
Helicobacter pylori , a chronic gastric pathogen of human beings, can be divided into seven populations and subpopulations with distinct geographical distributions. These modern derive their gene pools from ancestral that arose in Africa, Central Asia, East Asia. Subsequent spread attributed to migratory fluxes such as the prehistoric colonization Polynesia Americas, neolithic introduction farming Europe, Bantu expansion within slave trade.
We estimated the prevalences of Helicobacter pylori (formerly called Campylobacter pylori) infection and histologic gastritis in 113 asymptomatic persons, using endoscopic biopsy gastric antrum corpus. Unsuspected lesions, mainly mucosal erosions, were revealed at endoscopy 16 subjects (14 percent). Gastritis was found 42 (37 percent), whom 36 (32 percent total) to be infected with H. on basis hematoxylin-eosin staining. not any 71 normal features. noted both corpus 75 those (n = 27). The...
Background : Infection with Helicobacter pylori is a major risk factor for the development of atrophic gastritis and gastric cancer. H. strains can differ respect to presence cagA (cytotoxin-associated gene A), encoding high-molecular-weight immunodominant antigen. possessing have been associated enhanced induction acute inflammation. Purpose We investigated relationship between status in cohort subjects infected . Methods Gastrointestinal endoscopy biopsy sampling was used study natural...
Colonization of the gastric antrum by Helicobacter pylori (formerly Campylobacter pylori) has been associated with primary gastritis. We determined frequency colonization H. in gastric-antrum biopsy specimens from 93 children undergoing gastroscopy for evaluation upper gastrointestinal symptoms. also IgG antibody levels enzyme-linked immunosorbent assay coded serum samples these children, family members, and control subjects comparable ages.
This study examines the basis of resistance and sensitivity normal transformed cells to histone deacetylase inhibitor (HDACi)-induced cell death, specifically role caspases thioredoxin (Trx). An important attribute HDACis is that they induce cancer death at concentrations which are relatively resistant, making them well suited for therapy. The mechanism underlying this selectivity has not been understood. In we found HDACi suberoylanilide hydroxamic acid (SAHA) MS-275, a benzamide, cause an...
Study Objective: To determine the diagnostic value of assays to measure serum antibodies Campylobacter pylori, and use these prevalence C. pylori infection in a healthy population. Design: A survey patients having endoscopies for upper gastrointestinal symptoms, with other illnesses, controls. Setting: Outpatients attending endoscopy suites two university-affiliated medical centers. Patients: One hundred twenty who had gastroduodenoscopies, 61 lower intestinal 166 Intervention: Assay detect...
Persistent gastritis induced by Helicobacter pylori is the strongest known risk factor for adenocarcinoma of distal stomach, yet only a fraction colonized persons ever develop gastric cancer. The H. cytotoxin-associated gene ( cag ) pathogenicity island encodes type IV secretion system that delivers bacterial effector CagA into host cells after attachment, and + strains augment cancer risk. A aberrantly activated in precursor lesions β-catenin, activation β-catenin leads to targeted...
Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% strains bind fucosylated blood group antigen A, B, and O antigens (generalists), whereas 60% adherent South American Amerindian best (specialists). This specialization coincides with unique predominance in these Amerindians. Strains differed about 1500-fold binding affinities, diversifying selection was evident babA sequences. We propose cycles for increased decreased bacterial...
Psoriasis is a common chronic inflammatory disease of the skin. We sought to characterize and compare cutaneous microbiota psoriatic lesions (lesion group), unaffected contralateral skin from patients (unaffected similar loci in matched healthy controls (control group) order discern patterns that govern colonization their relationship clinical diagnosis.Using high-throughput 16S rRNA gene sequencing, we assayed bacterial communities 51 triplets characterized these samples using community...
Helicobacter pylori infection, thought to be causally related chronic gastritis, may also associated with an increased risk of gastric cancer. To determine whether association cancer does exist, we retrospectively evaluated serum samples from 69 patients histologically confirmed adenocarcinoma (32 at the cardia and 37 other sites) 218 one three categories nongastric cancers, or benign neoplasms. These were compared 252 cancer-free control subjects, a group comprising 76 asymptomatic...
Urease was purified 112-fold to homogeneity from the microaerophilic human gastric bacterium, Helicobacter pylori. The urease isolation procedure included a water extraction step, size exclusion chromatography, and anion exchange chromatography. enzyme exhibited Km of 0.3 +/- 0.1 mM Vmax 1,100 200 mumols urea hydrolyzed/min/mg protein at 22 degrees C in 31 Tris-HCl, pH 8.0. isoelectric point 5.99 0.03. Molecular mass estimated for native 380,000 30,000 daltons, whereas subunit values 62,000...
Colonization with Helicobacter pylori is a risk factor for gastric adenocarcinoma, but the magnitude of this association and its relationship to anatomic location cancer, duration follow-up, age at diagnosis, histologic subtype, H. strain differences are less clear. We conducted prospective nested case-control study serology address these questions.Case control subjects were selected from 29,133 50- 69-year-old males recruited into Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. At...
The seroprevalence of Helicobacter pylori infection was examined in the adult US population and among different ethnic groups. Stored sera from 7465 participants first phase third National Health Nutritional Examination Survey (1988–1991) were tested with a sensitive specific IgG ELISA, to diagnose infection. Seroprevalence H. all 32.5%. This increased age, 16.7% for persons 20–29 years old 56.9% those ⩾70 old. Age-adjusted prevalence substantially higher non-Hispanic blacks (52.7%) Mexican...
Background: Infection with Helicobacter pylori induces chronic gastritis in virtually all infected persons, and such has been associated an increased risk of developing gastric cancer. This is further enhanced cagA + (positive for cytotoxin-associated gene A) H. strains may be a consequence induced cell proliferation and/or alteration apoptosis (programmed death) the epithelium. Purpose: To determine whether genotype another virulence-related characteristic, vacA (vacuolating cytotoxin s1a...
The mechanism by which Helicobacter pylori, a noninvasive bacterium, initiates chronic antral gastritis in humans is unknown. We now show that H. pylori releases products with chemotactic activity for monocytes and neutrophils. This was inhibited antisera to either whole bacteria or pylori-derived urease. Moreover, surface proteins extracted from purified urease (a major component of the proteins) exhibited dose-dependent, antibody-inhibitable activity. In addition, synthetic 20-amino acid...
To determine whether a preexisting Helicobacter pylori infection increases the risk for developing duodenal or gastric ulcer.A nested case-control study based on cohort of 5443 Japanese-American men who had physical examination and phlebotomy from 1967 to 1970.All 10 general hospitals Hawaiian island Oahu.150 patients with ulcer 65 identified in participants after hospital surveillance period more than 20 years.Stored serum specimens matched controls were tested presence IgG antibody H....