A5035242320- Diabetes, Cardiovascular Risks, and Lipoproteins
- COVID-19 Clinical Research Studies
- Diabetes Management and Research
- Diabetes Treatment and Management
- Cardiovascular Health and Disease Prevention
- Physical Activity and Health
- Long-Term Effects of COVID-19
- Cardiovascular and exercise physiology
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Obesity, Physical Activity, Diet
- COVID-19 and healthcare impacts
- Blood Pressure and Hypertension Studies
- Diabetes Management and Education
- Pancreatic function and diabetes
- Heart Rate Variability and Autonomic Control
- Sepsis Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Health Promotion and Cardiovascular Prevention
- Diabetes and associated disorders
- Health, psychology, and well-being
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Skin Diseases and Diabetes
Danish Medicines Agency
2018-2021
Steno Diabetes Centers
2010-2019
Center for Clinical Research and Prevention
2018-2019
Frederiksberg Hospital
2018-2019
Danish Diabetes Academy
2014-2017
Glostrup Hospital
2017
Rigshospitalet
2017
Capital Region of Denmark
2016-2017
University of Copenhagen
2015-2016
University of Cambridge
2015
The role of glucose-stimulated release GLP-1 in the development obesity and type 2 diabetes is unclear. We assessed response to oral glucose a large study population lean obese men women with normal impaired regulation. Circulating concentrations glucose, insulin, during an tolerance test (OGTT) were analyzed individuals (NGT) (n = 774), prediabetes 525), or screen-detected 163) who attended Danish ADDITION-PRO 1,462). Compared NGT, had 25% lower OGTT, both 16-21% 120-min independent age...
Population-level knowledge on individuals at high risk of severe and fatal coronavirus disease 2019 (COVID-19) is urgently needed to inform targeted protection strategies in the general population.We examined characteristics predictors hospitalization death a nationwide cohort all Danish tested for acute respiratory syndrome 2 (SARS-CoV-2) from 27 February 2020 until 19 May 2020.We identified 11 122 SARS-CoV-2 polymerase chain reaction-positive cases whom 80% were community-managed 20%...
Hyperinsulinemia is an adaptive mechanism that enables the maintenance of normoglycemia in presence insulin resistance. We assessed whether glucagon also involved adaptation to A total 1,437 individuals underwent oral glucose tolerance test with measurements circulating glucose, insulin, and concentrations at 0, 30 120 min. Early suppression was defined as period from 0 min, late min after intake. Insulin sensitivity estimated by validated index. Individuals screen-detected diabetes had 30%...
Background Concerns over the safety of non-steroidal anti-inflammatory drug (NSAID) use during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been raised. We studied whether NSAIDs was associated with adverse outcomes and mortality SARS-CoV-2 infection. Methods findings conducted a population-based cohort study using Danish administrative health registries. included individuals who tested positive for period 27 February 2020 to 29 April 2020. NSAID users (defined...
Background Aortic stiffness is a strong predictor of cardiovascular disease endpoints. Cross-sectional studies have shown associations various risk factors with aortic pulse wave velocity, measure stiffness, but the long-term impact these on unknown. Methods In 3,769 men and women from Whitehall II cohort, wide range traditional novel were determined at baseline (1991–1993) velocity was measured follow-up (2007–2009). The prospective between each factor assessed through sex stratified linear...
Abstract Objective To perform an expedited assessment of cancer risk associated with exposure to N-nitrosodimethylamine (NDMA) through contaminated valsartan products. Design Nationwide cohort study. Setting Danish health registries on individual level prescription drug use, occurrence, and hospital diagnoses. Participants 5150 patients no history cancer, aged 40 years or older, using at 1 January 2012 initiating use between 30 June 2017. were followed from one year after entry (lag time...
Recent studies have suggested that a subgroup of obese individuals is not at increased risk obesity-related complications. This has been referred to as metabolically healthy obese. To investigate whether obesity factor for development ischemic heart disease (IHD) irrespective metabolic health. In all, 6238 men and women from the Danish prospective Inter99 study were followed during 10.6 (standard deviation = 1.7) years. General community. Participants classified according body mass index...
Abstract Background Venous thromboembolism (VTE) is a potentially fatal complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and thromboprophylaxis should be balanced against risk bleeding. This study examined risks VTE major bleeding in hospitalized community-managed SARS-CoV-2 patients compared with control populations. Methods Using nationwide population-based registries, 30-day positive were those test-negative an external cohort influenza patients....
Glucose-dependent insulinotropic polypeptide (GIP) may increase lipid clearance by stimulating uptake. However, given that GIP promotes release of insulin the pancreas and is anti-lipolytic, effect be indirect. In this study we examined association between metabolism in individuals with low to high risk type 2 diabetes assessed whether associations were modified or mediated through insulin. Analyses based on Danish cross-sectional ADDITION-PRO (n = 1405). Lipid was measured fasting plasma...
To facilitate research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a prospective cohort of all Danish residents tested for SARS-CoV-2 in Denmark is established.All by reverse transcriptase polymerase chain reactions (RT-PCR) are included. The identified using the Microbiology Database. Individual-level record linkage between administrative and health-care registries facilitated Civil Registration System. Information outcomes related to infection includes hospital...
Abstract Background Screening programmes for type 2 diabetes inevitably find more individuals at high risk than people with undiagnosed prevalent disease. While well established guidelines the treatment of exist, less is known about or prevention strategies found following screening. In order to make better use opportunities primary and its complications among this group, it important quantify progression rates examine development early markers cardiovascular disease microvascular diabetic...
There is little overlap between diabetes diagnosed by glycated hemoglobin (HbA1c) and blood glucose, it unclear which pathophysiological defects are captured when using HbA1c for diagnosis.We examined compared the relationship insulin sensitivity β-cell function in different subphenotypes of prediabetes type 2 (T2D).A cross-sectional analysis Danish ADDITION-PRO study was performed (n = 1713). Participants without known were classified into subgroups T2D based on fasting or 2-hour glucose...
Background: Up-to-date information on undiagnosed type 2 diabetes and prediabetes based current diagnostic criteria is lacking. The study aimed to model the total numbers of people with in Denmark existing population-based surveys. Methods: Two Danish studies HbA1c, date examination, gender, age known were identified: General Suburban Population Study, n = 21,205, Health Examination Survey, 18,065. prevalence known, pre-diabetes estimated population-level age-specific was from national...
Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes dysglycemia have shown associations with PA. To better understand PA glucose homeostasis, we examined association objectively measured energy expenditure (PAEE) detailed measures homeostasis.In 1,531 men women, low to high 7 days PAEE using a combined accelerometry heart rate monitor (ActiHeart). Measures indices homeostasis were derived from 3-point oral tolerance test in addition long-term...
Regional fat distribution rather than overall obesity has been recognized as important to understanding the link between and cardiovascular disease.We examined associations of abdominal visceral adipose tissue (VAT) subcutaneous (SAT) with risk factors in a Caucasian population men women normal glucose tolerance, prediabetes, or screen-detected diabetes.The study was based on cross-sectional analysis data from 1412 adults age 45-80 years. VAT SAT were assessed by ultrasound. The blood...
OBJECTIVE Aortic stiffness is an important predictor of future morbidity and mortality. Diabetes associated with increased aortic stiffness, but the importance nondiabetic glucometabolic status for accelerated stiffening unclear. We tested hypothesis that adverse in individuals without diabetes, independently known risk factors arterial stiffening. RESEARCH DESIGN AND METHODS Glucometabolic other cardiovascular were assessed at baseline 2008–09, carotid femoral pulse wave velocity (cfPWV)...
Abstract Objective To provide population-level knowledge on individuals at high risk of severe and fatal coronavirus disease 2019 (COVID-19) in order to inform targeted protection strategies the general population appropriate triage hospital contacts. Design, Setting, Participants Nationwide population-based cohort all 228.677 consecutive Danish tested (positive or negative) for acute respiratory syndrome 2 (SARS-CoV-2) RNA from identification first COVID-19 case February 27 th , 2020 until...
<h3>Importance</h3> During the ongoing coronavirus disease 2019 pandemic, case reports have suggested that use of nonsteroidal anti-inflammatory drugs (NSAIDs) may lead to adverse outcomes. <h3>Objective</h3> To study association NSAID with outcomes in patients hospitalized influenza or pneumonia. <h3>Design, Setting, and Participants</h3> This cohort used propensity score matching among 7747 individuals aged 40 years older who were influenza, confirmed by polymerase chain reaction antigen...
To examine the impact of ACE inhibitor (ACE-I)/angiotensin receptor blocker (ARB) use on rate SARS-CoV-2 infection and adverse outcomes. This nationwide case-control cohort study included all individuals in Denmark tested for RNA with PCR from 27 February 2020 to 26 July 2020. We estimated confounder-adjusted ORs a positive test among tested, inverse probability treatment weighted 30-day risk ratios (RRs) hospitalisation, intensive care unit (ICU) admission mortality comparing current...
Diabetes is associated with increased brachial and central blood pressure aortic stiffness. We examined the effect of intensive multifactorial treatment in general practice on indices peripheral hemodynamics among patients screen-detected diabetes.As part a population-based screening intervention study practice, 1,533 Danes aged 40-69 years were clinically diagnosed diabetes. General practitioners randomized to provide or routine care. After mean follow-up 6.2 years, an unselected subsample...
Physical activity is associated with reduced cardiovascular disease risk. However, improvements in conventional risk factors due to physical do not explain its full benefit. Therefore, we examined associations of objectively measured energy expenditure and intensity central hemodynamics provide new insight into the link between disease. We analyzed data from 1816 Danes (median age: 66 years) without was estimated using combined accelerometry heart rate monitoring. Aortic stiffness assessed...
Purpose: The aim of this study was to identify and describe somatic symptom profiles in the general adult population order enable further epidemiological research within multiple symptoms. Methods: Information on 19 self-reported common symptoms achieved from a population-based questionnaire survey 36,163 randomly selected adults Capital Region Denmark (55.4% women). participants stated whether they had been considerably bothered by each 14 days prior answering questionnaire. We used latent...
Ambiguity exists in relation to the role of physical activity (PA) for cardiovascular disease (CVD) risk reduction. We examined interplay between PA dimensions and more conventional CVD factors assess which were associated with first event whether subgroup differences exist. A total 1449 individuals [median age 65.8 (IQR: 61.2, 70.7) years] low high type 2 diabetes free from Danish ADDITION-PRO study included survival analysis. was measured by individually calibrated heart rate movement...