Objective: Polypharmacy is the concomitant use of several drugs by a single person, and it increases risk adverse drug-related events in older adults. Little known about epidemiology polypharmacy at population level. We aimed to measure prevalence incidence investigate associated factors. Methods: A prospective cohort study was conducted using register data with national coverage Sweden. total 1,742,336 individuals aged ≥65 years baseline (November 1, 2010) were included followed until death...

ABSTRACT Background Several drugs have been linked to the risk of microscopic colitis (MC), a condition characterised by watery, non‐bloody diarrhoea. Antibiotics can induce similar symptoms, but their connection MC remains unclear. Aim To investigate antibiotic‐related risks in adults aged 65 years and older. Methods This was nationwide, self‐controlled case series study including ≥ with new prescription for antibiotics biopsy‐confirmed, incident (Sweden, 2007–17). We identified cases from...

Abstract INTRODUCTION Polypharmacy is common among older adults and people with dementia. Multi‐medication therapy poses risks of harm but also targets comorbidities risk factors associated dementia, offering therapeutic potential. METHODS We evaluated the effects two polypharmacy regimens monotherapies on male female App NL‐G‐F knock‐in mice. assessed functional, emotional, cognitive outcomes;amyloid pathology; serum metabolomics profiles. RESULTS A combination metoprolol, simvastatin,...

The female advantage in life expectancy (LE) is found worldwide, despite differences living conditions, the status of women and other factors. However, this has decreased recent years low-mortality countries. Few researchers have looked at gender gap LE old age (age 65) a longer historical perspective. Have always had an do different countries share same trends? Life data for 17 were assessed from Human Mortality Database 1751 to 2007. Since most changes taking place today are driven by...

Background Polypharmacy is common among older adults. However, little known about the composition of polypharmacy: which are most frequently used drugs, and how much do these drugs contribute to overall prevalence polypharmacy. Methods A total 822,619 Swedes aged ≥75 years was identified from Total Population Register. Through record-linkage with Swedish Prescribed Drug Register Social Services we could analyze concurrent drug use in entire population (both individuals living community...

OBJECTIVE To evaluate the chronicity of polypharmacy among older adults and to identify factors associated with chronic polypharmacy. DESIGN Longitudinal cohort study using register data. SETTING Nationwide, Sweden. PARTICIPANTS All 711,432 (aged 65 years older) living in Sweden five or more prescription drugs October 2010 were included followed up until December 2013. Mean age at baseline was 77 (SD = 7.8) years, 59% women, 7% lived nursing homes. MEASUREMENT Monthly changes exposure Data...

We used data from SWEOLD, a Swedish nationally representative study of individuals aged 77 years or older, to examine midlife indicators job strain in relation cognitive performance and impairment. In all, 827 participants completed an abridged 11-point version the Mini-Mental State Examination in-person 1992 and/or 2002 had self-reported occupation-based scores for control demands collected 1968. Seventeen percent scored below cutoff Controlling age, sex, education, self-rated health, year...

the number of centenarians increases rapidly. Yet, little is known about their health and use medications.to investigate pharmacological drug in community-dwelling institutionalised compared with nonagenarians octogenarians.we analysed data on dispensed drugs for (n = 1,672), 76,584) octogenarians 383,878) from Swedish Prescribed Drug Register, record-linked to Social Services Register. Multivariate logistic regression analysis was used analyse whether age associated drugs, after adjustment...

Abstract Paracetamol (acetaminophen) is one of the most commonly used analgesics in Europe; however, both safety and efficacy paracetamol have recently been questioned. Little known about cross‐national differences sales paracetamol. Using national wholesale statistics nationwide prescription drug registers, we investigated trends total prescribed use Nordic countries. The (Anatomical Therapeutic Chemical ( ATC ) classification system code: N02 BE 01) measured as defined daily doses DDD per...

Objective: To determine whether or not the exposure to multiple drugs (polypharmacy) increases risk of fall-related injury among older adults, beyond effect fall-risk increasing and chronic multimorbidity. Methods: Nested case-control study using linked register data with national coverage in Sweden. We defined cases as adults (≥70 years) who had an incident non-elective admission due a fall between 1 January 31 December 2013. Cases were matched 1:1 on sex, age index date randomly selected...

The continuation of preventive drugs among older patients with advanced cancer has come under scrutiny because these are unlikely to achieve their clinical benefit during the patients' remaining lifespan.A nationwide cohort study adults (those aged ≥65 years) solid tumors who died between 2007 and 2013 was performed in Sweden, using routinely collected data record linkage. authors calculated monthly use cost throughout last year before death.Among 151,201 persons (mean age, 81.3 years...

Background: The high burden of disease-oriented drugs among older adults with limited life expectancy raises important questions about the potential futility care. Aim: To describe use questionable clinical benefit during last 3 months who died from life-limiting conditions. Design: Longitudinal, retrospective cohort study decedents. Death certificate data were linked to administrative and healthcare registries national coverage in Sweden. Setting: Older (≥75 years) conditions potentially...

ObjectivesTo map out the total use of long-term care (LTC; ie, home or institutional care) during last 2 years life and to investigate what extent gender differences in LTC were explained by cohabitation status age at death.DesignThe National Cause Death Register was used identify decedents. Use based on Social Services (SSR) sociodemographic factors provided Statistics Sweden.Setting ParticipantsAll persons living Sweden who died November 2015 aged ≥67 (n = 5948).MethodsZero inflated...

Abstract Sweden is known for high life expectancy and economic egalitarianism, yet in recent decades it has lost ground both respects. This study tracked income inequality old-age span variation between 2006 2015, examined whether patterns varied across levels of neighborhood deprivation. Income remaining at ages 65, 75, 85 increased. The gap age 65 grew by more than a year the lowest highest quartiles, men (from 3.4 years to 4.5 2015) women 2.3 years). widening was driven different rates...

Use of benzodiazepines (BZ) and related drugs is subject to considerable debate due problems with dependency adverse events. We aimed describe compare their use across the Nordic countries. Data on clonazepam, BZ-sedatives, BZ-hypnotics, benzodiazepine-related (BZRD) in adults (≥20 years) were obtained from nationwide registers Denmark, Finland, Iceland, Norway, Sweden, 2000-2020. Main measures therapeutic intensity (TI:DDD/1000 inhabitants [inhab.]/day) annual prevalence (users/1000...

A major challenge in the health care system is lack of knowledge about possible harmful effects multiple drug treatments old age.The present study aims to characterize a mouse model polypharmacy, order investigate whether long-term exposure drugs could lead adverse outcomes.To this purpose we selected five from ten most commonly used by older adults Sweden (metoprolol, paracetamol, aspirin, simvastatin and citalopram).Five-month-old wild type male mice were fed for eight weeks with control...

Current research on potentially inappropriate prescribing (PIP) in polymedicated older adults with atrial fibrillation (AF) and multimorbidity is predominantly focused PIP of oral anticoagulants (OAC). Our study aimed to assess (i) the overall prevalence multimorbid AF, (ii) potential associated factors PIP, (iii) association adverse health outcomes a nationwide sample Swedish adults.

ABSTRACT Objective To investigate the age, period, and cohort effects of polypharmacy in older adults using Swedish register data covering period 2006 to 2020. Design Repeated cross‐sectional study routinely‐collected health care data. Setting Nationwide, Sweden. Participants A 10% random sample was drawn each year from source population all aged ≥ 65 Sweden, 2006–2020 (cumulative n > 3,000,000). Measurement Polypharmacy defined as use 5 medicines. Drug were extracted National Prescribed...

Evidence on the cardiotoxicity of nonaspirin nonsteroidal antiinflammatory drugs (NSAIDs), particularly diclofenac and newer selective cyclooxygenase (COX)-2 inhibitors, has accumulated over last decade. Our objective was to examine whether use NSAIDs in Nordic countries changed with emerging evidence, regulatory statements, clinical guidelines advocating caution for specific NSAIDs.Drug utilization study.Nationwide wholesale statistics prescription registries Denmark, Finland, Iceland,...