A5020555133- Cancer survivorship and care
- Angiogenesis and VEGF in Cancer
- Family Support in Illness
- Palliative Care and End-of-Life Issues
- Cancer-related cognitive impairment studies
- COVID-19 and healthcare impacts
- Venous Thromboembolism Diagnosis and Management
- Childhood Cancer Survivors' Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- Lymphatic System and Diseases
- Telemedicine and Telehealth Implementation
- Cardiac and Coronary Surgery Techniques
- Protease and Inhibitor Mechanisms
- Colorectal Cancer Surgical Treatments
- Nanoplatforms for cancer theranostics
- Inflammatory Biomarkers in Disease Prognosis
- Psoriasis: Treatment and Pathogenesis
- Sleep and related disorders
- Health and Wellbeing Research
- Global Cancer Incidence and Screening
- Blood transfusion and management
- Complement system in diseases
- Mesenchymal stem cell research
- Insect symbiosis and bacterial influences
- Retinoids in leukemia and cellular processes
Zealand University Hospital
2019-2025
Hvidovre Hospital
2001-2010
University of Copenhagen
2002-2010
Copenhagen University Hospital
2007
Follow-up after breast cancer with regular visits has failed to detect recurrences, be cost-effective, and address patient needs.
Background and purpose: We previously demonstrated positive effects on quality of life mental health following breast cancer when comparing a nurse-led follow-up program without scheduled visits (MyHealth) to regular follow-up. This study aims examine whether MyHealth also positively impacts self-reported work ability. Patients/material methods: A total 288 patients, potentially active the labour market, were randomized or control after primary treatment for early-stage (2017–2019). included...
focused on patients living with metastatic cancer. We examined the feasibility of SleepNow intervention combining cognitive behavioral therapy for insomnia (CBT-I) physical exercise in men prostate cancer (mPCa). Patients/material and methods: conducted a randomized trial under treatment castration resistant mPCa (Insomnia Severity Index [ISI] score ≥ 8). Patients were 1:1 to either or usual care. is manualized 12-week program consisting bi-weekly sessions four nurse-led CBT-I. care received...
Interleukin (IL)-6, a key player in the inflammatory response, may be useful biomarker rheumatoid arthritis (RA). The aim was to determine analytical variability, reference interval healthy subjects, and long- short-term variation serum plasma IL-6 subjects RA patients. An enzyme-linked immunosorbent assay from R&D used for determination of IL-6. concentration did not depend on type anticoagulant or 3-h time delay between sampling processing repeated freeze-thaw cycles. median 318 were 1.3...
Abstract Mannan‐binding lectin (MBL) and MBL‐associated serine protease 2 (MASP‐2) are central components of the MBL pathway complement activation, may have potential as clinical biomarkers in colorectal cancer (CRC). Prior to usage, knowledge biological variations molecules is needed. We here investigate MASP‐2 healthy persons over time relation gender, age physical activity. concentrations were determined serum from adults a 3‐week period this was repeated 6 months later ( n = 32); during...
Abstract Serum YKL-40 is a potential biomarker of prognosis in cancer patients, but assessment serum requires knowledge its normal variation. In this study, we evaluated diurnal, weekly, and long-term variation healthy subjects using commercial ELISA. The intra-assay coefficient was ≤5.0% interassay ≤10.2%. Systematic changes diurnal measurements could not be shown. Physical exercise for 20 min had no effect on YKL-40. within-subject variation, including over time interassay, 28.8% 30.2%...
Background : Soluble vascular endothelial growth factor (VEGF) is a promising biomarker in monitoring rheumatoid arthritis (RA), but studies of pre‐analytical and biologic variability are few. Methods VEGF was measured by ELISA methods serum plasma from healthy persons RA patients. Pre‐analytical factors were investigated. A reference interval for established 306 persons. Diurnal, day‐to‐day, week‐to‐week, long‐term variability, impact exercise evaluated. Results Delayed processing time,...
Background: Traditionally, women treated for breast cancer (BC) have been followed up through regular oncologist-led visits in outpatient clinics, focusing on detection of recurrences, new primary BC, symptom management, and psychological support. However, this follow-up routine is expensive its effectiveness has questioned. Consequently, alternative programs tested. The Guided Self-Determination method (GSD), which facilitates partnership between health-care provider patient, shown to...
Background During the COVID-19 pandemic, teleconsultations (TC) have been increasingly used in cancer care as an alternative to outpatient visits. We aimed examine patient-related and cancer-specific characteristics associated with experiences TC among patients during pandemic. Material methods This population-based survey included breast, lung, gastrointestinal, urological, gynaecological cancers appointments clinics, Department of Clinical Oncology Palliative Care, Zealand University...
Major restructuring of surveillance after breast cancer treatment with less follow-up consultations may result in insecurity and fear recurrence (FCR) among the resourceful patients. We investigate association between patients' education FCR if self-efficacy mediates associations FCR.A questionnaire survey was conducted from 2017 to 2019, 1773 patients shortly having their switched regular outpatient visits an oncologist either nurse-led or patient-initiated follow-up, a subsequent 12...
Background and Objectives Poor prognosis after resection of primary colorectal cancer may be related to the combination perioperative blood transfusion subsequent development infectious complications. White cell‐ platelet‐derived growth substances, including vascular endothelial factor (VEGF), involved in this process. Therefore, we studied vitro release VEGF from white cells platelets stimulated by bacterial antigens supernatants stored red cell components. Materials Methods Eight units...
Abstract Objective Pre‐ and post‐operative plasma tissue inhibitor of metalloproteinases‐1 (TIMP‐1) levels have a prognostic impact on patients with colorectal cancer. However, the surgical trauma may play an essential role in regulation TIMP‐1 levels, which turn influence subsequent measurements. Patients methods Consecutively, 48 colon cancer (CC) 12 nonmalignant colonic disease were randomised to undergo elective laparoscopically assisted or open resection followed by fast track recovery....
This pilot study investigated the hypothesis that tumour itself is source of elevated vascular endothelial growth factor (VEGF) concentrations which are often observed in peripheral blood from patients with rectal cancer. Twenty‐four consecutive primary cancer were included. Blood samples drawn preoperatively veins (I) and intraoperatively (II), arteries (III), (IV). In four compartments, VEGF measured serum, EDTA plasma, supernatants lysed whole blood. Additionally, automated complete white...
Background: The urokinase-type plasminogen activation (uPA) system and the mannan-binding lectin (MBL) complement pathway are involved in regulation of immune responses. blood concentrations these molecules individual patient thus could be related to risk postoperative infectious complications. aim this retrospective study was determine association between soluble uPA receptor (suPAR) MBL development bacterial Methods: Blood samples were drawn preoperatively from 544 patients scheduled...
Abstract Purpose During the COVID-19 pandemic, teleconsultations have increasingly been used to reduce physical contact and thus risk of infection. This study investigated how patients with cancer experienced pandemic they perceived change from in-person consultations telephone in an oncology outpatient clinic. The aim was provide insights that could optimize future use care. Methods qualitative included 15 colorectal, breast, gynecological, lung, or prostate treated at clinic Department...
Oncologist-led follow-up after breast cancer (BC) is increasingly replaced with less intensive based on higher self-management, which may overburden the resourceful patients. We examined whether socioeconomic factors measured recently implementation of a new program for BC patients were associated health-related quality life (HRQoL) and self-management 12 months later.Between January August 2017, we invited 1773 in Region Zealand, Denmark, to participate baseline questionnaires. The had...
Abstract We developed the Navigate intervention to improve survival among vulnerable lung cancer patients. In this intervention-only study, we examined feasibility in terms of recruitment , retention attendance adherence, and acceptability specify adjustments study procedures components prior a randomized trial. The includes nurse navigation, patient-reported outcomes, physical exercise. Patients ≥ 18 years old, diagnosed with non-small cell at any stage, performance status ≤ 2, eligible for...
Introduction. Vascular Endothelial Growth Factor (VEGF) plays a prominent role in tumor angiogenesis and plasma VEGF concentration may carry prognostic information colorectal cancer. The receptor 1 (VEGFR-1) is regulatory which shredded into of patients with For both molecules, large biological variation lack standardization assay procedures are major challenges. Methods. We investigated pre-analytical, analytical, as well short term long VEGFR-1 volunteers. In addition, we evaluated markers...
Increased plasma concentrations of vascular endothelial growth factor (sVEGF) are associated with poor prognosis colorectal cancer patients. The aim was to investigate the contribution tumor VEGF and receptor 1 (VEGFR1). Preoperative blood samples from a peripheral vein intraoperative artery, vein, were drawn 28 patients undergoing elective surgical resection primary rectal cancer. Plasma VEGFR1 determined by ELISA. Counts white cells platelets performed in all samples. No significant...
Objective. The influence of surgery on release soluble vascular endothelial growth factor (sVEGF) and the inhibitory receptor (sVEGFR1) is unknown. effect major minor variations in sVEGF sVEGFR1 concentrations vivo was studied, bacterial antigen‐induced from whole blood vitro. Material methods. Sixty‐one patients with abdominal diseases undergoing five different surgical procedures were included study. Blood samples drawn before after operation. White cells platelets counted, plasma...
Abstract Background: Follow-up after breast cancer with regular specialist-led visits has failed to prove superiority over other strategies in terms of recurrence detection and survival, but it is still a cornerstone follow-up many healthcare systems. provided by the general practitioner or specialist nurse been reported more cost-effective non-inferior patient-reported health-related quality life (HRQoL) meeting needs survivors. However, no have demonstrated indisputable strategies....