A5101743119- Liver Disease Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Inflammatory Bowel Disease
- Liver Diseases and Immunity
- Advanced biosensing and bioanalysis techniques
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Atherosclerosis and Cardiovascular Diseases
- Helicobacter pylori-related gastroenterology studies
- Peroxisome Proliferator-Activated Receptors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hepatitis Viruses Studies and Epidemiology
- Diet, Metabolism, and Disease
- Cholesterol and Lipid Metabolism
- Organ Transplantation Techniques and Outcomes
- Immune Response and Inflammation
- Genetic factors in colorectal cancer
- Tuberculosis Research and Epidemiology
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- interferon and immune responses
- Diet and metabolism studies
Ondokuz Mayıs University
2025
Bursa Uludağ Üni̇versi̇tesi̇
2019-2024
Marmara University
2009-2024
Ankara Bilkent City Hospital
2024
Bilkent University
2024
Recep Tayyip Erdoğan University
2024
Ordu University
2021
Tokat Gaziosmanpaşa Üniversitesi
2019
Creative Commons
2015
Izmir Kâtip Çelebi University
2015
Data regarding outcome of COVID-19 in patients with autoimmune hepatitis (AIH) are lacking.
Abstract Background and Aim The prevalence clinical significance of extrahepatic autoimmune diseases (EHAIDs) have not been evaluated in a large cohort primary biliary cholangitis (PBC). Methods medical records 1554 patients with PBC from 20 international centers were retrospectively reviewed. Development decompensated cirrhosis (ascites, variceal bleeding, and/or hepatic encephalopathy) hepatocellular carcinoma considered endpoints. Results A total 35 different EHAIDs diagnosed 440 (28.3%)...
We investigated associations between baseline use of immunosuppressive drugs and severity Coronavirus Disease 2019 (COVID-19) in autoimmune hepatitis (AIH).Data AIH patients with laboratory confirmed COVID-19 were retrospectively collected from 15 countries. The outcomes who on immunosuppression at the time compared to not medication. clinical courses classified as (i)-no hospitalization, (ii)-hospitalization without oxygen supplementation, (iii)-hospitalization supplementation by nasal...
Vascular endothelial growth factor (VEGF) is the important angiogenic associated with tumor and metastasis in a wide variety of solid tumors. The aim this study to investigate suppressive effect chitosan/small interfering RNA (siRNA)-VEGF nanoplexes rat breast cancer model. Chitosan/siRNA (siVEGF-A, siVEGFR-1, siVEGFR-2) NRP-1 were prepared 15 to1 ratio injected (intratumorally) into breast-tumor-bearing Sprague-Dawley rats. Tumor volumes measured during 21 days. To chitosan/siRNA on VEGF...
INTRODUCTION: Risk stratification based on biochemical variables is a useful tool for monitoring ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC). Several UDCA response criteria and scoring systems have been proposed risk prediction in PBC, but these not validated large external cohorts. METHODS: We performed study data of 1746 UDCA-treated PBC from 25 centers Europe, United States, Canada. The prognostic performance the (GLOBE UK-PBC) (Barcelona, Paris I,...
Background: Familial Mediterranean Fever is a common genetic autoinflammatory disease prevalent in the region. The clinical course of characterized by fever and serositis attacks. While defects innate immune system are known to play role pathogenesis disease, impact adaptive remains unclear. Therefore, main objective this study analyze cells FMF patients investigate their relationship with disease. Methods: Our includes 88 confirmed MEFV gene mutations. demographic characteristics, symptoms,...
Vascular endothelial growth factor (VEGF) plays a critical role in angiogenesis. The aim of this study was to use chitosan/short hairpin VEGF (shVEGF) [short RNA (shRNA)-expressing pDNA targeting VEGF-A] complexes the treatment rat breast cancer model. Therefore, chitosan/shVEGF were prepared (2/1) ratio and injected breast-tumor bearing Sprague–Dawley rats. Intratumoral intraperitoneal injections applied compared. Tumor volumes measured during 36 days. To investigate effect on expression,...
Observed low prevalence of SLE among familial Mediterranean fever (FMF) patients in several large cohorts suggests a possible protective effect the MEFV mutations from SLE. In contrast, patient carriers for common had rather complex disease expression with an increased frequency febrile episodes and pleurisy decreased renal complication rate. Our aim was to investigate gene their on organ involvement well-defined group biopsy-proven nephritis patients.The four (M694V, M680I, V726A E148Q)...
Journal Article Association between bactericidal/permeability increasing protein (BPI) gene polymorphism (Lys216Glu) and inflammatory bowel disease Get access Hakan Akın, Akın * a Marmara University Faculty of Medicine, Gastroenterology Department, Istanbul, Turkey Corresponding author. Gastroenterology, Üniversitesi Hastanesi Gastroenteroloji Bölümü 34660, Altunizade, Turkey. Tel.: + 90 5326584237; fax: 2662452051. Search for other works by this author on: Oxford Academic PubMed Google...
Congenital adrenal hyperplasia (CAH) is a group of genetic endocrine disorders, caused by enzyme deficiencies in the conversion cholesterol to cortisol. More than 90% cases have 21-hydroxylase deficiency (21-OHD). The clinical phenotype disease classified as classic, severe form, and nonclassic, mild form. In this study, it was planned characterize mutations that cause 21-OHD Turkish CAH patients direct sequencing multiplex ligation-dependent probe amplification (MLPA) analysis investigate...
Cardiovascular risk factors and atherosclerosis precursors were examined in 365 Turkish children adolescents. Study participants recruited at five different state schools. We tested single multi-locus effects of six polymorphisms from candidate genes, chosen based on prior known association with lipid levels adults, for low (≤10th percentile) high density lipoprotein cholesterol (HDL-C) (≥90th triglycerides (TG), the related continuous outcomes. observed an between CETP variant rs708272...
AIM: Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells.Increased ADM level has been linked to hyperdynamic circulation arterial vasodilatation cirrhotic portal hypertension (CPH).The role of non-cirrhotic (NCPH) unknown.plasma levels were studied patients with NCPH, compensated decompensated cirrhosis order determine its contribution (PH) these groups.METHODS: There 4 groups subjects.Group 1 consisted 27 (F/M: 12/15)...
Insulin resistance is associated with obesity, glucose intolerance or diabetes, hypertension, dyslipidemia, and cardiovascular disease. Constellation of these risk factors iscalled metabolic syndrome (MetS). MetS common among postmenopausal women. Low sex hormone binding globulin (SHBG) levels associate an increased in Variations SHBG gene low circulating levels. We aim to study the association between polymorphisms - rs1799941 (A/G) rs6257 (T/C) women.The population consisted 182 women 119...
Metabolic syndrome (MetS) is a complex disorder characterized by coexistence of several cardiometabolic (CM) factors, i.e. hyperlipidemia, obesity, high blood pressure and insulin resistance. The presence MetS strongly associated with increased risk cardiovascular disease (CVD). was originally defined as an adult disorder, but has become increasingly recognized in children adolescents. Genetic variants influence biological components common to the CM factors that comprise MetS. We...