A5057435596- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Pancreatitis Pathology and Treatment
- Long-Term Effects of COVID-19
- Pediatric Hepatobiliary Diseases and Treatments
- COVID-19 Clinical Research Studies
- Renal Transplantation Outcomes and Treatments
- Gallbladder and Bile Duct Disorders
- Hepatitis Viruses Studies and Epidemiology
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis B Virus Studies
- Alcohol Consumption and Health Effects
- Pancreatic and Hepatic Oncology Research
- SARS-CoV-2 and COVID-19 Research
- Hormonal Regulation and Hypertension
- Diabetes and associated disorders
- Herpesvirus Infections and Treatments
- Global Maternal and Child Health
- Neurological Complications and Syndromes
- Gastrointestinal disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
Hospital Clínico de la Universidad de Chile
2013-2025
University of Chile
2008-2024
Clinica Santa Maria
2021-2023
Weatherford College
2021
Medicina
2018
Universidad de Los Andes, Chile
2012
Clínica Las Condes
2008
A few case reports of autoimmune hepatitis-like liver injury have been reported after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. We evaluated clinical features, treatment response and outcomes following SARS-CoV-2 vaccination in a large series.We collected data from cases 18 countries. The type was assessed with the R-value. study population categorized according to features immune-mediated hepatitis (positive autoantibodies elevated immunoglobulin G levels)...
Data regarding outcome of COVID-19 in patients with autoimmune hepatitis (AIH) are lacking.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a complex disorder whose prevalence rapidly growing in South America. The disturbances the microbiota–gut–liver axis impact damaging processes toward fibrosis. Gut microbiota status shaped by dietary and lifestyle factors, depending on geographic location. We aimed to identify microbial signatures group of Chilean MASLD patients. Forty subjects were recruited, including healthy controls (HCs), overweight/obese (Ow/Ob),...
We investigated associations between baseline use of immunosuppressive drugs and severity Coronavirus Disease 2019 (COVID-19) in autoimmune hepatitis (AIH).Data AIH patients with laboratory confirmed COVID-19 were retrospectively collected from 15 countries. The outcomes who on immunosuppression at the time compared to not medication. clinical courses classified as (i)-no hospitalization, (ii)-hospitalization without oxygen supplementation, (iii)-hospitalization supplementation by nasal...
The independent effect of liver biochemistries as a prognostic factor in patients with COVID-19 has not been completely addressed. We aimed to evaluate the value abnormal tests on admission hospitalized COVID-19. performed prospective cohort study including 1611 confirmed SARS-CoV-2 infection from April 15, 2020 through July 31, 38 different Hospitals 11 Latin American countries. registered clinical and laboratory parameters, function tests, during hospitalization. All were followed until...
Chronic renal failure causes left ventricular hypertrophy, but the molecular mechanisms involved remain unknown. We, therefore, investigated whether mineralocorticoid receptor is implicated in cardiac hypertrophy observed uremic rats and blockade could be protective chronic failure. Experimental groups were: control rats, (NPX) with 5/6 nephrectomy (5 weeks), NPX fed spironolactone for 5 weeks. Systolic blood pressure was increased both Echocardiography revealed concentric uremia, which...
Infection by the hepatitis B virus (HBV) represents a significant global socio-sanitary burden. While liver transplantation (LT) is an important therapeutic option, treatments that prevent HBV reinfection are necessary. The combination of anti-hepatitis immunoglobulin (HBIG) and nucleoside/nucleotide analogs (NA) standard post-transplant treatment; however, there limitations in using HBIG, particularly its cost. We present two illustrative clinical cases as examples management dual NA...
Patients with metabolic dysfunction-associated steatotic liver disease (MASLD) are at an increased cardiovascular risk. On the contrary, non-alcoholic fatty (NAFLD) is highly prevalent in patients coronary heart (CHD). However, it not known whether significant CHD show a higher frequency of fibrosis. This study aimed to determine MASLD and fibrosis assess stenosis significantly associated observational analytical included adult without any who underwent angiography for suspected artery (Jul...
Viral infections have been described to increase the risk of decompensation in patients with cirrhosis. We aimed determine effect SARS-CoV-2 infection on outcome hospitalized cirrhosis and compare performance different prognostic models for predicting mortality.We performed a prospective cohort study including 2211 confirmed from April 15, 2020 through October 1, 38 Hospitals 11 Latin American countries. registered clinical laboratory parameters without All were followed until discharge or...
Autoimmune hepatitis (AIH) is a chronic liver disease with relevant inflammatory component and an unknown etiology. Evidence for clinical characteristics risk factors in large cohorts of patients acute AIH (AAIH) lacking. We clinically characterized AAIH, the prevalence combined adverse outcome (death or transplantation (LT)), its factors.A retrospective study adult diagnosed AAIH at three centers (Santiago, Chile; 2000-2018) was conducted. Clinical laboratory were obtained. A biopsy...
Acute liver failure (ALF) is a life-threatening condition that remains challenging for physicians despite several advances in supportive care. Etiologies vary worldwide, with herpes simplex virus (HSV) hepatitis representing less than 1% of cases. Despite its low incidence, ALF lethal cause acute necrotizing and has high mortality. Early antiviral treatment beneficial survival decreased transplantation necessity. However, plasmapheresis, theoretical potential benefit, scarcely reported.A...
Retrospective studies suggest that coronavirus disease (COVID-19) commonly involves gastrointestinal (GI) symptoms and complications. Our aim was to prospectively evaluate GI manifestations in patients hospitalized for COVID-19. This international multicentre prospective cohort study recruited COVID-19 at 31 centres Spain, Mexico, Chile, Poland, between May September 2020. Patients were followed-up until 15 days post-discharge completed comprehensive questionnaires assessing A descriptive...
Acute-on-chronic liver failure (ACLF) is associated with reduced short-term survival, and transplantation frequently the only therapeutic option. Nonetheless, post-transplantation prognosis seems to be worse in ACLF patients.The databases of two university centers were retrospectively evaluated, adult patients cirrhosis who underwent between 2013 2020 included. One-year survival was compared that without ACLF. Variables mortality identified.A total 428 303 met inclusion criteria; 57.1% male,...
Background: The polymorphism rs58542926 C > T (E167K) in the gene of transmembrane 6 superfamily member 2 (TM6SF2) has been identified as a determinant hepatic steatosis and fibrosis patients with non-alcoholic fatty liver disease. Only limited data have published on this subject chronic hepatitis (CHC). Objectives: This study aimed to evaluate effect TM6SF2 risk Chilean CHC infection. Methods: A total 153 biopsied were genotyped for using PCR-RFLP methodology. was assessed by comparing...
National and regional distribution of hepatitis C virus genotypes in ChileGenotyping has an important prognostic value for response to antiviral therapy.The results hepatits genotyping performed between 1994 2012 from 1,766 patients different regions Chile are reported.Global genotype (Gt) was as follows: 7.87% Gt1a, 72.71% Gt1b, 1.98% Gt2, 16.53% Gt3a, 0.57% Gt4, 0.28% Gt5a 0.06% Gt6.In most the similar global.However, there were some differences, particular south our country, where 3a is...
Retrospective studies suggest that coronavirus disease (COVID-19) commonly involves gastrointestinal (GI) symptoms and complications. Our aim was to prospectively evaluate GI manifestations in patients hospitalized for COVID-19. This international multicentre prospective cohort study recruited COVID-19 at 31 centres Spain, Mexico, Chile, Poland, between May September 2020. Patients were followed-up until 15 days post-discharge completed comprehensive questionnaires assessing A descriptive...
Little is known about current practice of liver transplantation (LT) in Latin American countries (LATAM). This study aimed to describe LT activity, immunosuppression protocols and policies regarding prophylaxis cytomegalovirus (CMV) infection hepatitis B virus (HBV) recurrence different active LATAM centers. A web-based survey with 20 questions was sent all members ALEH SIG December 2022. 22 centers performing 35 [5-160] per year from Brazil (n=5), Argentina (n=4), Chile Ecuador (n-2),...
Metabolic associated liver disease (MAFLD) is one of the most frequent causes chronic worldwide. Steatohepatitis a major risk factor for fibrosis and its progression. MAFLD might be present in other damage, such as autoimmune hepatitis (AIH). There scarce information role patients with AIH. This study aimed to describe frequency steatosis, steatohepatitis AIH biopsies impact steatosis on severity survival. Observational, retrospective performed prior initiation immunosuppressive therapy,...