A5087320050- Liver Disease Diagnosis and Treatment
- Iron Metabolism and Disorders
- Liver Disease and Transplantation
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- COVID-19 Clinical Research Studies
- Hemoglobinopathies and Related Disorders
- Liver Diseases and Immunity
- Dysphagia Assessment and Management
- Trace Elements in Health
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Folate and B Vitamins Research
- Pancreatitis Pathology and Treatment
- Diet, Metabolism, and Disease
- Gallbladder and Bile Duct Disorders
- Hepatitis Viruses Studies and Epidemiology
- Cardiovascular Health and Disease Prevention
- Systemic Sclerosis and Related Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
Hospital de Clínicas "José de San Martín"
2015-2025
University of Buenos Aires
2012-2025
National University of Misiones
2021
Weatherford College
2021
Martin University
2021
Maastricht University
2013
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Most studies addressing epidemiology HCC originate from developed countries. This study reports preliminary findings a multinational approach to characterize in South America.We evaluated 1336 patients seen at 14 centres six American countries using retrospective design with participating completing template chart patient characteristics. The diagnosis was made radiographically or histologically for...
Introduction The immune system acts on different metabolic tissues that are implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Leptin and linoleic acid have ability to potentially affect cells, whereas curcumin is a known natural polyphenol with antioxidant anti-inflammatory properties. Aims This study was designed evaluate pro-inflammatory pro-oxidant effects leptin cells from patients NAFLD corroborate modulatory its preventive properties against progression using...
Background and Aims: The prognostic weight of further decompensation in cirrhosis is still unclear. We investigated the incidence its effect on mortality patients with cirrhosis. Approach Results: Multicenter cohort study. cumulative (development a second event or complication decompensating event) was assessed using competing risks analysis 2028 patients. A 4-state model built: first decompensation, liver transplant, death. cause-specific Cox used to assess adjusted mortality. Sensitivity...
The independent effect of liver biochemistries as a prognostic factor in patients with COVID-19 has not been completely addressed. We aimed to evaluate the value abnormal tests on admission hospitalized COVID-19. performed prospective cohort study including 1611 confirmed SARS-CoV-2 infection from April 15, 2020 through July 31, 38 different Hospitals 11 Latin American countries. registered clinical and laboratory parameters, function tests, during hospitalization. All were followed until...
Hepatic lipase is a lipolytic enzyme mostly synthesized and localized at the surface of liver sinusoidal capillaries, which hydrolyses triglycerides phospholipids intermediate density, large low density (LDL) high lipoproteins. activity increased in insulin resistant states. Non-alcoholic fatty disease (NAFLD) characterized by resistance. However, present, no data are available regarding behaviour hepatic with regard to degree steatosis. Our aim was evaluate NAFLD patients its relationship...
Introducción. La disinergia defecatoria es un trastorno funcional caracterizado por la falta de coordinación entre las contracciones abdominales y relajación del esfínter anal, lo que provoca constipación crónica. Los síntomas principales incluyen sensación evacuación incompleta esfuerzo defecatorio excesivo. Su diagnóstico requiere excluir causas orgánicas evaluar alarma empleando examen rectal digital, manometría anorrectal alta resolución test expulsión balón. se clasifica en 4 subtipos...
Summary The Lyon Consensus defines pathological gastroesophageal reflux disease (GERD) as an acid exposure time (AET) greater than 6%, while AET less 4% rules it out. between and 6% is borderline. Prolonged wireless capsule pH monitoring may enhance GERD diagnosis, though not widely used in Latin America. This study aimed to categorize patients with borderline or non-GERD using prolonged monitoring, assess treatment response, compare tolerance interference 24-hour impedance testing....
Viral infections have been described to increase the risk of decompensation in patients with cirrhosis. We aimed determine effect SARS-CoV-2 infection on outcome hospitalized cirrhosis and compare performance different prognostic models for predicting mortality.We performed a prospective cohort study including 2211 confirmed from April 15, 2020 through October 1, 38 Hospitals 11 Latin American countries. registered clinical laboratory parameters without All were followed until discharge or...
Summary Background Ursodeoxycholic acid (UDCA) is the first‐line therapy for primary biliary cholangitis (PBC). However, nearly 40% of patients have an incomplete response to UDCA. The addition bezafibrate has shown biochemical benefit in this group patients. Aim To evaluate long‐term effects UDCA combination with on histological outcomes UDCA‐refractory PBC. Methods Fifty‐nine refractory were included. Clinical parameters monitored and paired liver biopsy (PLB) was performed after 5 years...
As the involvement of intestinal microbiota in etiopathology irritable bowel syndrome, subtype diarrhoea (IBS-D) is now increasingly recognised, a preliminary, quasi-experimental, before-after and prospective study was conducted on 28 patients to test effect tannin-based supplement composition activity microbiota, after 8 weeks treatment. No statistically significant differences were found α- or β-diversity. However, sparse Partial Least Squares Discriminant Analysis (sPLS-DA) Boruta...
Abstract Objective To assess sublingual microcirculation in cirrhotic patients and its relationship to spider angiomas, complications, outcome. Methods Thirty‐one were prospectively compared 31 matched controls. Sublingual was evaluated by videomicroscopy. We specifically looked for capillaries with increased RBCV, which defined as a velocity higher than the percentile 100th of Results Compared controls, showed decreased total PVD (14.4 ± 2.2 vs 16.0 1.3 14.1 2.3 15.9 1.6 mm/mm 2 ,...
Iron overload (IO) has been associated with glucose metabolism alterations and increased risk of cardiovascular disease (CVD). Primary IO is mutations in the HFE gene. To which extent gene metabolic contribute to presence atherogenic lipoprotein modifications primary remains undetermined. The present study aimed assess small, dense low-density (LDL) levels, chemical composition LDL high-density (HDL) particles, HDL functionality patients. Eighteen male patients 16 sex- age-matched controls...
Summary Background The burden of non‐alcoholic fatty liver disease (NAFLD) in South America is among the highest world. However, epidemiology and risk factors for NAFLD are insufficiently described region. Aim To explore associations between clinical characteristics histopathological features Methods This was a descriptive study 2722 patients with from 8 medical centres across 5 American countries. We collected clinical, biochemical data using templated chart. Fibrosis assessed by...
La dehiscencia de la anastomosis colorrectal es una complicación postquirúrgica seria que aumenta morbilidad, mortalidad, duración internación hospitalaria y los costos atención médica significativamente. Su frecuencia oscila entre el 4 26%. Depende, otros factores riesgo, edad avanzada, enfermedad maligna, tiempo prolongado cirugía, radioterapia preoperatoria pérdida sangre perioperatoria o necesidad transfusiones. Las manifestaciones clínicas pueden ser variadas, como presencia dolor...
Introduction: Obesity is an emerging pandemic driven by consumption of a diet rich in fat, highly refined carbohydrates and sedentary lifestyle both children adults. In obesity arterial stiffness (AS) often associated with endotelial dysfunction (ED) independent strong predictor cardiovascular disease (CVD) precursor to atherosclerosis, systolic hypertension, cardiac diastolic dysfunction, impairment coronary cerebral flow. obese children, AS also promotes fatty liver whitch eventually leads...