Josefina Pagés
A5011472735- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal Transplantation Outcomes and Treatments
- Healthcare Systems and Reforms
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 Clinical Research Studies
- Antibiotics Pharmacokinetics and Efficacy
- Urinary Tract Infections Management
- Global Maternal and Child Health
- COVID-19 Impact on Reproduction
- Global Healthcare and Medical Tourism
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Pancreatitis Pathology and Treatment
- Hepatitis C virus research
- Folate and B Vitamins Research
- Adrenal Hormones and Disorders
- Long-Term Effects of COVID-19
- Liver physiology and pathology
- Alcohol Consumption and Health Effects
- Epilepsy research and treatment
- Antimicrobial Resistance in Staphylococcus
Hospital Universitario Austral
2018-2025
Austral University
2017-2024
University of Buenos Aires
2021
Education and Research Network
2021
Hospital Italiano de Buenos Aires
2018
Background & AimsGenetic ancestry or racial differences in health outcomes exist diseases associated with systemic inflammation (eg, COVID-19). This study aimed to investigate the association of genetic and race acute-on-chronic liver failure (ACLF), which is characterized by acute inflammation, multi-organ failure, high risk short-term death.MethodsThis prospective cohort analyzed a comprehensive set data, including among several others, 1274 patients acutely decompensated cirrhosis who...
To investigate any changing trends in the etiologies of hepatocellular carcinoma (HCC) Argentina during last years.A longitudinal cohort study was conducted by 14 regional hospitals starting 2009 through 2016. All adult patients with newly diagnosed HCC either pathology or imaging criteria were included. Patients classified as presenting non-alcoholic fatty liver disease (NAFLD) histology clinically, provided that all other ruled out, present on abdominal ultrasound and alcohol consumption...
The independent effect of liver biochemistries as a prognostic factor in patients with COVID-19 has not been completely addressed. We aimed to evaluate the value abnormal tests on admission hospitalized COVID-19. performed prospective cohort study including 1611 confirmed SARS-CoV-2 infection from April 15, 2020 through July 31, 38 different Hospitals 11 Latin American countries. registered clinical and laboratory parameters, function tests, during hospitalization. All were followed until...
ABSTRACT Background and Aims The survival outcomes associated with hepatic recompensation in patients advanced hepatocellular carcinoma (HCC) treated first‐line systemic therapies remain unclear. We compared from the initiation of treatments for HCC among compensated, decompensated, recompensated cirrhosis. Methods A Latin American multicenter, prospective cohort study was conducted 2018 to 2024, involving Child‐Pugh class or B who received therapy. At time therapy, cirrhosis were...
Viral infections have been described to increase the risk of decompensation in patients with cirrhosis. We aimed determine effect SARS-CoV-2 infection on outcome hospitalized cirrhosis and compare performance different prognostic models for predicting mortality.We performed a prospective cohort study including 2211 confirmed from April 15, 2020 through October 1, 38 Hospitals 11 Latin American countries. registered clinical laboratory parameters without All were followed until discharge or...
there is insufficient data regarding bacterial infections in patients with cirrhosis to support recommendations for empiric antibiotic treatments, particularly Latin America. This study aimed evaluate infection's clinical impact and microbiological characteristics, intending serve as a platform revise current practices.multicenter prospective cohort of from Argentina Uruguay. Patient infection-related information were collected, focusing on microbiology, susceptibility patterns, outcomes.472...
The liver imaging reporting data system (LI-RADS) for hepatocellular carcinoma (HCC) was proposed to standardize and enhance consensus of reporting. However, clinical utility LI-RADS has not been evaluated in Latin America. We therefore sought compare categories with histopathology findings transplant (LT) explants a regional center.Prospective cohort study conducted between 2012 2018 single center from Argentina including patients HCC listed LT. definitions were applied magnetic resonance...
Abstract Controversy exists whether NE after LT are more frequently observed in children or adults. We aimed to compare the incidence and outcomes for pediatric adult recipients. A single‐center cohort study, including all between 2001 2013, was performed. Definition of included impaired consciousness, delirium, seizures, focal neurologic deficit, visual impairment, slurred speech. 443 consecutive recipients included: 307 adults 136 children. Cumulative similar 15% (n = 41) 16% 20; P .73)...
Latin America (LA) includes 20 countries, with significant cultural and economic diversity. In order to develop regional liver transplant (LT) guidelines, the LT ALEH special interest group (SIG) made a survey aimed at investigating current status of pre- evaluation in LA. A 150 questions-survey was distributed LT-SIG members 01-05/2023. descriptive analysis performed. answers from 14 countries were obtained. All performed except one. Financing private 5%, public 32% mixed 63%. Allocation...
Little is known about current practice of liver transplantation (LT) in Latin American countries (LATAM). This study aimed to describe LT activity, immunosuppression protocols and policies regarding prophylaxis cytomegalovirus (CMV) infection hepatitis B virus (HBV) recurrence different active LATAM centers. A web-based survey with 20 questions was sent all members ALEH SIG December 2022. 22 centers performing 35 [5-160] per year from Brazil (n=5), Argentina (n=4), Chile Ecuador (n-2),...
Antibiotic de-escalation is considered a safe strategy that reduces costs and the risk of multi-drug resistant infections. However, its prevalence associated factors in real-life practice were not reported patients with cirrhosis Latin-America. To estimate antibiotic real life-practice, to explore factors. We performed an analysis multicenter prospective cohort study cirrhotic bacterial infections throughout Argentina Uruguay (clinicatrials.gov NCT03919032). Patients who died first 72 hs...
Selecting an empiric antibiotic treatment in patients with cirrhosis and spontaneous bacterial infections is challenging. It of paramount importance to have local epidemiological data maximize pathogen coverage while minimizing the unnecessary use broad-spectrum antibiotics. This study aimed describe patterns resistance according site acquisition. Analysis multicenter prospective cohort cirrhotic Argentina Uruguay (NCT03919032). Only culture-positive were included this study: peritonitis...