A5069394992- Chronic Lymphocytic Leukemia Research
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Organ Transplantation Techniques and Outcomes
- Lymphoma Diagnosis and Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Cardiovascular Function and Risk Factors
- Transplantation: Methods and Outcomes
- Reconstructive Surgery and Microvascular Techniques
- Atrial Fibrillation Management and Outcomes
- Hernia repair and management
- Drug-Induced Adverse Reactions
- Single-cell and spatial transcriptomics
- Breast Implant and Reconstruction
- Hepatitis C virus research
- T-cell and B-cell Immunology
- Galectins and Cancer Biology
- Colorectal and Anal Carcinomas
- Hip and Femur Fractures
- Alcohol Consumption and Health Effects
- Thyroid and Parathyroid Surgery
- Liver physiology and pathology
Hospital Clínic de Barcelona
2022-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2023-2025
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2023-2025
Universitat de Barcelona
2023-2024
Luxembourg Institute of Health
2019-2024
University of Luxembourg
2020-2023
Hospital Del Mar
2019-2022
Municipal Institute for Medical Research
2019
Hospital del Mar Research Institute
2019
Centre d’Immunologie de Marseille-Luminy
2018
Dysregulation of mRNA translation, including preferential translation with complex 5'-UTRs such as the MYC oncogene, is recognized an important mechanism in cancer. In this study, we show that both human and murine chronic lymphocytic leukemia (CLL) cells display a high rate, which can be inhibited by synthetic flavagline FL3, prohibitin (PHB)-binding drug. A multiomics analysis consisting pulsed SILAC, RNA sequencing polysome profiling performed CLL patient samples cell lines treated FL3...
The Gender-Equity Model for liver Allocation corrected by serum sodium (GEMA-Na) and the End-stage Liver Disease 3.0 (MELD 3.0) could amend sex disparities accessing transplantation (LT). We aimed to assess these inequities in Spain compare performance of GEMA-Na MELD 3.0.
Abstract Background The optimal cardiovascular assessment of liver transplant (LT) candidates is unclear. We aimed to evaluate the performance CT‐based coronary tests (coronary artery calcium score [CACS] and CT angiography [CCTA]) a modification CAD‐LT (mCAD‐LT, excluding family history CAD) diagnose significant disease (CAD) before LT predict incidence post‐LT events (CVE). Methods retrospectively analysed single‐centre cohort who underwent non‐invasive tests; invasive (ICA) was performed...
Chronic lymphocytic leukemia (CLL) cells are highly dependent on interactions with the immunosuppressive tumor microenvironment (TME) for survival and proliferation. In search novel treatments, pro-inflammatory cytokines have emerged as candidates to reactivate immune system. Among those, interleukin 27 (IL-27) has recently gained attention, but its effects differ among malignancies. Here, we utilized Eμ-TCL1 EBI3 knock-out mouse models well clinical samples from patients investigate role of...
Although liver transplantation (LT) recipients are at high cardiovascular risk (CVR), the management of CVR factors (CVRF) after LT is far from optimal and needs to be improved. For this reason, we developed a multidisciplinary protocol standardize identification, stratification, management, targets therapy CVRF during first post-LT year. The grade identification control 12 months in postintervention cohort (LT January 2018-January 2020, n = 150) were compared with who underwent between July...
In the past 20 years, interest for tumor microenvironment (TME) has exponentially increased. Indeed, it is now commonly admitted that TME plays a crucial role in cancer development, maintenance, immune escape and resistance to therapy. This stands true hematological malignancies as well. A considerable amount of newly developed therapies are directed against cancer-supporting instead targeting cells themselves. However, often not clearly defined. addition, unique phenotype each variability...
Regulatory T cells (Tregs) are capable of inhibiting the proliferation, activation and function play an important role in impeding immune response to cancer. In chronic lymphocytic leukemia (CLL) a dysfunctional elevated percentage effector-like phenotype Tregs have been described. this study, using Eµ-TCL1 mouse model CLL, we evaluated changes their expansion at different stages progression. Importantly, show that depletion DEREG mice triggered new anti-leukemic cytotoxic cell clones...
Abstract Abnormal liver function tests (A‐LFTs) during admission for coronavirus disease‐19 (COVID‐19) are frequent, but its evolution after COVID‐19 resolution remains unexplored. We evaluated factors related to A‐LFTs and assessed the outcome patients' discharge. This is a observational study including: (1) retrospective analysis of variables COVID‐19; (2) follow‐up evaluation with blood test, transient elastography biopsy in those persistent A‐LFTs. were defined according CTCAEv4.0. Among...
Abstract Failure of cancer immunotherapy is linked to T cell exhaustion. To decipher the underlying mechanisms, we explored landscape in blood, bone marrow and lymph node samples patients with chronic lymphocytic leukemia (CLL), spleen a CLL mouse model. By single-cell RNA-sequencing, mass cytometry (CyTOF), multiplex image analysis tissue microarrays, identified disease-specific accumulation distinct regulatory subsets exhaustion stages their trajectories nodes. Integration receptor...
Chronic lymphocytic leukemia (CLL) is the most common adult in western world. It characterized by a high dependency on interactions with surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic interventions. We recently revealed that cytokine IL-27 exerts strong anti-tumor role CLL through T-cell-mediated mechanism.
Chronic lymphocytic leukemia (CLL) is the most frequent in elderly and characterized by accumulation of mature B lymphocytes peripheral blood primary lymphoid organs. In order to proliferate, leukemic cells are highly dependent on complex interactions with their microenvironment proliferative niches. Not only soluble factors BCR stimulation important for survival proliferation, but also activation transcription through different signaling pathways. The aryl hydrocarbon receptor (AHR)...