A5103100731- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Tracheal and airway disorders
- Hepatitis Viruses Studies and Epidemiology
- Gut microbiota and health
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Dysphagia Assessment and Management
- Connective tissue disorders research
- dental development and anomalies
- Intestinal Malrotation and Obstruction Disorders
- Child Nutrition and Feeding Issues
- Cystic Fibrosis Research Advances
- Oral and Maxillofacial Pathology
- Intestinal and Peritoneal Adhesions
- Vascular anomalies and interventions
- SARS-CoV-2 and COVID-19 Research
- Omental and Epiploic Conditions
- Systemic Lupus Erythematosus Research
- Neonatal Respiratory Health Research
- Diverse Scientific Research Studies
- Abdominal Trauma and Injuries
- Immunodeficiency and Autoimmune Disorders
Hospital Universitario Miguel Servet
2008-2024
Sociedad Andaluza de Medicina Familiar y Comunitaria
2021-2022
Andalusian Health Service
2021-2022
Hospital Universitario Austral
2010-2022
Austral University
2017-2019
Complejo Hospitalario de Pontevedra
2019
Inserm
1992-1994
Data from Europe and North America have been published regarding the risk of developing hepatocellular carcinoma (HCC) after treatment with direct antiviral agents (DAA). We proposed to evaluate cumulative incidence associated factors for de novo HCC.This was a prospective multicentre cohort study Latin including 1400 F1-F4-treated patients DAAs (F3-F4 n = 1017). Cox proportional regression models (hazard ratios, HR 95% CI) were used independent variables HCC. Further adjustment competing...
A pro-oncogenic intestinal microbiome was observed in murine models; however, no specific patients with hepatocellular carcinoma (HCC) has been reported. We aimed to compare the gut found cirrhotic or without HCC. From 407 Child Pugh A/B cirrhosis prospectively followed, 25 HCC (cases) were matched (wo-HCC) a 1:1 ratio according age, gender, etiology, and severity of portal hypertension. In addition, results also compared healthy subjects. Fecal stool samples sequenced for V3–V4 region...
Recent advances in the treatment of hepatitis C virus (HCV) infection have produced highly effective all-oral directacting antivirals (DAA) therapies with minimal side effects and short duration.This is encouraging news for 71 million persons estimated to be chronically infected HCV worldwide. 1From a public health perspective, prevalence shall eliminated if available also targeted those who most likely transmit virus.Despite this scientific breakthrough, systematic review from USA described...
The ECHO model was developed to expand access medical care for populations with HCV infection in underserved areas. We aimed compare treatment outcomes community-based clinics the Austral University Hospital (AUH) and assess improvement physician knowledge skills. In October 2015, we established an clinic at AUH Buenos Aires. To evaluate impact of this programme, conducted a prospective cohort study comparing healthcare providers from different Argentinean provinces. A survey evaluating...
Abstract BACKGROUND The prevalence of chronic hepatitis B virus (HBV) infection is high in patients with end‐stage renal disease and kidney transplant recipients, there little experience treatment using the newer antiviral drugs. aim this study was to assess efficacy safety entecavir HBV difficult‐to‐treat population. METHODS Eleven male patients—1 stage 4 disease, 7 undergoing hemodialysis, 3 recipients‐were included evaluation. Six were naïve, 5 lamivudine resistant. Entecavir administered...
Abstract Controversy exists whether NE after LT are more frequently observed in children or adults. We aimed to compare the incidence and outcomes for pediatric adult recipients. A single‐center cohort study, including all between 2001 2013, was performed. Definition of included impaired consciousness, delirium, seizures, focal neurologic deficit, visual impairment, slurred speech. 443 consecutive recipients included: 307 adults 136 children. Cumulative similar 15% (n = 41) 16% 20; P .73)...
The exact significance of antibodies to hepatitis C virus (HCV) in blood donors remains unknown. Confirmatory tests anti-HCV-reactive serum and HCV RNA by polymerase chain reaction (PCR) are used refute a large proportion false-positive results.Ninety-two who were anti-HCV reactive first-generation enzyme-linked immunosorbent assay (ELISA) reevaluated 10 months later with second-generation ELISA (ELISA-2) as well recombinant immunoblot (RIBA-2) PCR.Twenty-five (43.9%) the 57 ELISA-2-positive...
La disfagia es muy frecuente en niños con discapacidad neurológica. Estos pacientes suelen presentar problemas respiratorios y nutricionales. El estudio de la deglución por videofluoroscopia (VFC) suele ser el más recomendado, ya que revela situación real durante deglución. Estudiar los resultados obtenidos evaluación diagnóstica tras un año desde implantación VFC nuestro centro, analizar mejoría clínica confirmación prescripción tratamiento individualizado orofaríngea. Se recogen las...
Although the effectiveness of direct-acting antivirals (DAAs) for treatment chronic hepatitis C virus (HCV) has been reported in real-world settings, predictive factors failure are lacking. Therefore, we sought to explore baseline predictors response DAAs.
Schwannomas are tumours originating in the Schwann cells of peripheral nerves. The appearance colon is extremely rare, and there no known cases literature schwannomas rectum described children. These usually asymptomatic, but can produce non-specific gastrointestinal symptoms. clinical presentation as intestinal intussusception infrequent. We present a case an 11-year-old girl with sigmoid swchannoma presented clinically colonic abdominal pain, rectal bleeding constipation 10 days. An...
En los últimos años, se han incrementado significativamente las peticiones de tomografía computada (TC) para la evaluación preoperatoria dientes supernumerarios (SN) en niños. El objetivo nuestro trabajo es describir forma detallada y concisa SN, basándonos pacientes diagnosticados centro. Se realizó un análisis retrospectivo estudios TC maxilofacial, realizados entre años 2011 2015. Recopilamos datos (género edad), motivos solicitud hallazgos tomográficos. Los SN fueron clasificados según...
Dysphagia is very common in children with neurological disabilities. These patients usually suffer from respiratory and nutritional problems. The videofluoroscopic swallowing study (VFSS) the most recommended test to evaluate dysphagia, as it shows real situation during swallowing. To analyse results obtained our centre after one year of implementation VFSS, clinical improvement confirmation, prescription an individualised treatment for affected. VFSS performed previous were collected....
To achieve WHO's goal of eliminating hepatitis C virus (HCV), innovative strategies must be designed to diagnose and treat more patients. Therefore, we aimed describe an implementation strategy identify patients with HCV who were lost follow-up (LTFU) offer them re-linkage care. We conducted study utilizing a contact not under regular in 13 countries from Latin America. Patients identified by the international classification diseases (ICD-9/10) or equivalent. Medical records then reviewed...
SUMMARY Background No specific microbiome in patients with hepatocellular carcinoma (HCC) has been reported to date. Aim To compare the gut found cirrhotic and without HCC. Methods From 407 Child Pugh A/B cirrhosis prospectively followed, 25 HCC (cases) were matched (wo-HCC) a 1:1 ratio according age, gender, etiology, severity of portal hypertension. In addition results also compared healthy subjects. Faecal stool samples collected noninvasively, aliquoted for DNA extraction sequenced V3-V4...
The introduction of direct-acting antiviral (DAA) agents promises to change dramatically the management hepatitis C in kidney transplant recipients, a patient group where treatment is historically challenging. purpose current study was assess (in 'real-life' setting) safety and efficacy all-oral, interferon-free, recipients with HCV. We performed single-arm, multi-center cohort (n = 95) who underwent therapy DAAs. primary end-point sustained virologic response (SVR) (serum HCV RNA < 15...
Abstract Background Arterial tortuosity syndrome (ATS) (OMIM #208050) is a very rare autosomal recessive connective tissue disease characterized by elongation, tortuosity, and predisposition of aneurysms formation in medium large-caliber arteries, vascular dissection, ischemic events. To date, approximately 100 patients have been reported carrying some the fewer than 35 causal mutations SLC2A10 gene. Case presentation Here we present clinical molecular characterization two new Spanish...
Renal artery stenosis represents a rare cause of neonatal arterial hypertension renovascular origin, having been described few cases in the literature at this stage life. Most patients with disease remain asymptomatic; can be detected routine pediatric revisions. Diagnosis performed by combining biochemical and radiological findings. The initial management consists pharmacological therapy order to achieve adequate growth. Subsequently, it is necessary assess definitive repair vascular lesion...