A5007351094- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Inflammatory Bowel Disease
- Microscopic Colitis
- Liver Disease and Transplantation
- Tuberculosis Research and Epidemiology
- Colorectal Cancer Screening and Detection
- Pediatric Hepatobiliary Diseases and Treatments
- Pharmacy and Medical Practices
- Sarcoidosis and Beryllium Toxicity Research
- Parathyroid Disorders and Treatments
- Digestive system and related health
- Celiac Disease Research and Management
- Head and Neck Cancer Studies
- Gastrointestinal disorders and treatments
- Eosinophilic Esophagitis
- Chronic Kidney Disease and Diabetes
- Gallbladder and Bile Duct Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Urticaria and Related Conditions
- Diagnosis and treatment of tuberculosis
- Chronic Lymphocytic Leukemia Research
- Mycobacterium research and diagnosis
- Gout, Hyperuricemia, Uric Acid
- Helicobacter pylori-related gastroenterology studies
Jackson Memorial Hospital
2018-2025
University of Miami
2019-2025
Emory University
2023
Center for Cancer Research
2016
Albany Medical Center Hospital
2015
Data regarding outcome of COVID-19 in patients with autoimmune hepatitis (AIH) are lacking.
Background and Aims The impact of sex on the postcirrhosis progression primary biliary cholangitis (PBC) has not been well defined. Prior studies have suggested that men worse outcomes but present at more advanced stages fibrosis than women. This observation, however, limited by small numbers even fewer patients with cirrhosis. Approach Results We investigated association development all‐cause liver‐related mortality or transplantation, decompensation, hepatocellular carcinoma (HCC), using...
Deregulation of the tumour suppressor PTEN occurs in lung and skin fibrosis diabetic ischaemic renal injury. However, potential role associated mechanisms progression kidney is unknown. Tubular interstitial expression was dramatically decreased several models injury, including aristolochic acid nephropathy (AAN), streptozotocin (STZ)-mediated injury ureteral unilateral obstruction (UUO), correlating with Akt, p53 SMAD3 activation fibrosis. Stable silencing HK-2 human tubular epithelial cells...
INTRODUCTION: Patients with cirrhosis and men have been under-represented in most studies examining the clinical benefit of response to ursodeoxycholic acid (UDCA) primary biliary cholangitis (PBC). The aim this study was association UDCA liver-related death or transplantation, hepatic decompensation, hepatocellular carcinoma (HCC) patients PBC cirrhosis. METHODS: We conducted a retrospective cohort veterans, predominantly men, compensated assess development all-cause mortality HCC using...
We investigated associations between baseline use of immunosuppressive drugs and severity Coronavirus Disease 2019 (COVID-19) in autoimmune hepatitis (AIH).Data AIH patients with laboratory confirmed COVID-19 were retrospectively collected from 15 countries. The outcomes who on immunosuppression at the time compared to not medication. clinical courses classified as (i)-no hospitalization, (ii)-hospitalization without oxygen supplementation, (iii)-hospitalization supplementation by nasal...
Immunocompromised patients, including those who received an organ transplant, were excluded from coronavirus disease 2019 (COVID-19) vaccine clinical trials.1Polack F.P. et al.N Engl J Med. 2020; 383: 2603-2615Crossref PubMed Scopus (9292) Google Scholar,2John B.V. al.JAMA Intern 2021; 181: 1306-1314Crossref (66) Scholar Transplant patients are at high risk of severe disease3Webb G.J. al.Lancet Gastroenterol Hepatol. 5: 1008-1016Abstract Full Text PDF (183) but may not manifest adequate...
The impact of social determinants health in inflammatory bowel disease (IBD) remains understudied. We evaluated the barriers on IBD outcomes within a diverse cohort patients.We performed cross-sectional study adult patients and assessed known health. calculated total prevalence these sample as whole each ethnic group. summed number present for individual to create cumulative barrier score (SBS), we relationship SBS with outcomes, including activity depressive symptoms.A 316 were included...
Protein phosphatase magnesium-dependent-1A (PPM1A) dephosphorylates SMAD2/3, which suppresses TGF-β signaling in keratinocytes and during Xenopus development; however, potential involvement of PPM1A chronic kidney disease is unknown. expression was dramatically decreased the tubulointerstitium obstructive aristolochic acid nephropathy, correlates with progression fibrotic disease. Stable silencing human kidney-2 renal epithelial cells increased SMAD3 phosphorylation, stimulated genes,...
The natural history of patients with anti-mitochondrial antibody (AMA)-negative Primary Biliary Cholangitis (PBC) cirrhosis has not been well defined, prior studies showing discordant results. Furthermore, most AMA-negative PBC have limited numbers and liver-related outcomes.We investigated the association development death, decompensation hepatocellular carcinoma (HCC), in a large cohort predominantly male assembled from Veterans Health Administration.In 521 (65 AMA-negative) total...
Combined checkpoint inhibition therapy targeting the programmed cell death 1 (PD-L1) and cytotoxic T-lymphocyte associated protein 4 pathways has been a successful approach in treatment of metastatic melanoma, leading to its investigation head neck squamous carcinoma (HNSCC) with PD-L1 expression. Despite potential for excellent responses, an increased rate autoimmune neurological toxicity paraneoplastic conditions observed when using these modalities. We present case patient HNSCC treated...
Limited data exist on adherence to fecal calprotectin (FCP) testing in patients with inflammatory bowel disease.Completion rates for who had at least one FCP test ordered (n = 3082) and a subgroup C-reactive protein, complete blood count, Clostridium difficile tests also 1563) were analyzed.More completed than stool tests, having the poorest of all analyzed. Older higher completion rates. No differences noted across age, gender, or ethnicity tests.Further studies are needed develop...
Abstract Introduction In this study, we identify the frequency of pseudopolyps (PPs) with normal histology and their association to surrounding tissue. Methods Patients were enrolled in a study identifying endoscopic characteristics PPs (n = 29) or collected as part our IBD biobank 16). Statistical analysis included Stata v.15.0. chi-square Student t-test. Results A total 45 patients 117 PP biopsies identified. More healed remission compared those inflammatory (82.6% vs 17.4%, respectively)....