Christina Mikkelsen
A5005859784- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Sports injuries and prevention
- Blood donation and transfusion practices
- SARS-CoV-2 and COVID-19 Research
- Organ Donation and Transplantation
- Lower Extremity Biomechanics and Pathologies
- Migraine and Headache Studies
- COVID-19 Clinical Research Studies
- Hemoglobinopathies and Related Disorders
- Reproductive Biology and Fertility
- Blood groups and transfusion
- Shoulder Injury and Treatment
- Ovarian function and disorders
- Pregnancy and preeclampsia studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Congenital heart defects research
- Tendon Structure and Treatment
- Foot and Ankle Surgery
- Complement system in diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Iron Metabolism and Disorders
- COVID-19 epidemiological studies
- Personality Disorders and Psychopathology
- Maternal and fetal healthcare
University of Copenhagen
2017-2025
Copenhagen University Hospital
2020-2025
Rigshospitalet
2022-2025
Novo Nordisk Foundation
2020-2025
Novo Nordisk Foundation Center for Basic Metabolic Research
2021-2025
Aarhus University Hospital
2024-2025
University of Exeter
2024
University of Tartu
2024
Karolinska Institutet
2003-2022
Liverpool John Moores University
2020
The pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has tremendous consequences for our societies. Knowledge of the seroprevalence SARS-CoV-2 is needed accurately monitor spread epidemic and calculate infection fatality rate (IFR). These measures may help authorities make informed decisions adjust current societal interventions. objective was perform nationwide real-time surveying among blood donors as a tool estimate previous infections population-based...
Background: A lateral patellar dislocation (LPD) is the most common traumatic knee injury with hemarthrosis in children. The redislocation rate high. Varying operative and nonoperative treatments have been advocated no consensus on best treatment. Purpose: (1) To evaluate if arthroscopic-assisted repair of medial patellofemoral ligament (MPFL) patients an acute first-time LPD would reduce recurrence offer better objective/subjective function compared a brace without repair. (2) study...
To assess the percentage of patients achieving an acceptable symptom state 2 years after primary anterior cruciate ligament reconstruction (ACLR) and to identify factors affecting its achievement, in a large cohort.Patients who underwent ACLR at Capio Artro Clinic, Stockholm, Sweden, from 2005 2015, were identified our clinic registry. Patients had completed Knee injury Osteoarthritis Outcome Score (KOOS) 2-year follow-up included. The outcome was achievement patient-acceptable (PASS) for...
To assess the percentage of patients achieving symmetrical knee function 6 months after primary anterior cruciate ligament (ACL) reconstruction (ACLR) and to identify factors affecting its achievement, in a large cohort. Data were extracted from our clinic database. Patients who underwent ACLR 2000 2015 assessed with isokinetic quadriceps hamstring muscles strength tests single-leg-hop test at 6-month follow-up included study. Demographic data, information on graft used, cartilage injuries...
Introduction of the Omicron variant caused a steep rise in SARS-CoV-2 infections despite high vaccination coverage Danish population. We used blood donor serosurveillance to estimate percentage recently infected residents similarly aged background population with no known comorbidity.To detect antibodies induced due recent infection, and not vaccination, we assessed anti-nucleocapsid (anti-N) immunoglobulin G (IgG) samples. Individual level data on RT-PCR results status were available....
Abstract Migraine is a complex neurovascular disease with range of severity and symptoms, yet mostly studied as one phenotype in genome-wide association studies (GWAS). Here we combine large GWAS datasets from six European populations to study the main migraine subtypes, aura (MA) without (MO). We identified four new MA-associated variants (in PRRT2 , PALMD ABO LRRK2 ) classified 13 MO-associated variants. Rare effects highlight three genes. A rare frameshift variant brain-expressed confers...
Abstract Genome-wide association studies (GWASs) may help inform the etiology of infertility. Here, we perform GWAS meta-analyses across seven cohorts in up to 42,629 cases and 740,619 controls identify 25 genetic risk loci for male female We additionally 269 associated with follicle-stimulating hormone, luteinizing estradiol testosterone through sex-specific ( n = 6,095–246,862). Exome sequencing analyses reveal that women carrying testosterone-lowering rare variants some genes are at...
Abstract Background The pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has tremendous consequences for our societies. Knowledge of the seroprevalence SARS-CoV-2 is needed accurately monitor spread epidemic and also calculate infection fatality rate (IFR). These measures may help authorities make informed decisions adjust current societal interventions. Blood donors comprise approximately 4.7% similarly aged population Denmark blood donated in all areas country....
Abstract Genome-wide association studies (GWASs) may help inform treatments for infertility, whose causes remain unknown in many cases. Here we present GWAS meta-analyses across six cohorts male and female infertility up to 41,200 cases 687,005 controls. We identified 21 genetic risk loci ( P ≤5E-08), of which 12 have not been reported any reproductive condition. found positive correlations between endometriosis all-cause r g =0.585, =8.98E-14), polycystic ovary syndrome anovulatory =0.403,...
The efficacy of photodynamic therapy (PDT) with methyl aminolevulinate is reduced when treating actinic keratosis (AK) on the extremities in comparison face and scalp. Studies indicate that PDT can be improved by combining other treatment modalities. This randomized intra-individual study investigated whether pretreatment topical 5% 5-fluorouracil (5-FU) enhanced daylight-mediated 24 patients AKs hands. One hand each patient was given 7 days 5-FU twice daily before daylight-PDT, whereas...
Abstract Purpose To evaluate and compare changes in quadriceps hamstring strength single-leg-hop (SLH) test performance over the first 24 postoperative months patients who underwent anterior cruciate ligament reconstruction (ACLR) with bone-patellar tendon-bone (BPTB) or tendon (HT) autografts followed either a standard an accelerated rehabilitation protocol. Methods A total of 160 undergoing ACLR were randomised four groups depending on graft that was used protocol (40 BPTB/standard rehab,...
Polygenic risk scores (PRSs) are expected to play a critical role in precision medicine. Currently, PRS predictors generally based on linear models using summary statistics, and more recently individual-level data. However, these mainly capture additive relationships limited data modalities they can use. We developed deep learning framework (EIR) for prediction which includes model, genome-local-net (GLN), specifically designed large-scale genomics The supports multi-task learning, automatic...
Polycystic ovary syndrome (PCOS) and its underlying features remain poorly understood. In this genetic proteomic study, we expand the number of loci from 19 to 29, identify 31 associated plasma proteins. Many risk-increasing were with later age at menopause, underscoring reproductive longevity related a larger functional ovarian reserve. Hormonal regulation in aetiology condition, through metabolic features, was emphasised. The analysis highlighted perturbations metabolically-related biology...
Abnormal plasma sodium concentration represents an imbalance of total body water relative to electrolyte content. Hyponatremia is a common and potentially severe adverse event, thiazide diuretics constitute leading cause drug-induced hyponatremia. We conducted genome-wide association study analyses concentration, thiazide-induced decrease in hyponatremia 188,464 individuals European ancestry . Additionally, we tested for gene-environment interaction between polygenic score developed exposure...
Objective To characterise gastrointestinal symptoms and bowel habits in healthy blood donors explore symptom phenotypes their associated factors. Methods Between November 2020 March 2023, 53 046 participants the nationwide Danish Blood Donor Study completed a questionnaire including 13 symptoms, defaecation pattern regularity, stool frequency, consistency. We used data-driven approach to investigated factors by multinomial logistic regression. Results Among (52% women), 68% (95% CI 67.5%...
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