David A. Ehrmann
A5101618475- Ovarian function and disorders
- Reproductive Biology and Fertility
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Pancreatic function and diabetes
- Ovarian cancer diagnosis and treatment
- Genetic Associations and Epidemiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Growth Hormone and Insulin-like Growth Factors
- Diabetes and associated disorders
- Hormonal and reproductive studies
- Bariatric Surgery and Outcomes
- Lipid metabolism and disorders
- Sperm and Testicular Function
- Thyroid Cancer Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Irish and British Studies
- Sexual Differentiation and Disorders
- Smoking Behavior and Cessation
- Noise Effects and Management
- Peroxisome Proliferator-Activated Receptors
- Thyroid Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Calpain Protease Function and Regulation
University of Chicago
2005-2024
Massachusetts General Hospital
2022
Vanderbilt University Medical Center
2022
George Washington University
2022
Washington Center
2022
National Institutes of Health
2022
Prevention Group
2022
University of Chicago Medical Center
2001
Mater Misericordiae Hospital
1993
The aim was to formulate practice guidelines for the diagnosis and treatment of polycystic ovary syndrome (PCOS).
To investigate the basis of polycystic ovary syndrome, we examined responses patients to nafarelin, a specific gonadotropin-releasing-hormone agonist, given stimulate pituitary and gonadal secretion. We compared 16 normal women in follicular phase, 5 men, 8 with 1 woman syndrome caused by 3β-hydroxysteroid dehydrogenase deficiency. After 100 μg nafarelin was subcutaneously, serum follicle-stimulating hormone luteinizing increased rapidly peak levels within four hours. The had pattern similar...
Women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency often have a polycystic ovary-like syndrome, consisting of hyperandrogynism, infertility, menstrual irregularities, and elevated LH levels. This is generally considered secondary poor control the hyperplasia. However, our experience led us suspect that ovarian hyperandrogenism occurs even when well controlled on glucocorticoid therapy. Therefore, we tested hypothesis virilizing disorders result in hyperandrogenism. We...
We examined the effects of metformin on diabetes prevention and subgroups that benefited most over 15 years in Diabetes Prevention Program (DPP) its follow-up, Outcomes Study (DPPOS).During DPP (1996-2001), adults at high risk developing were randomly assigned to masked placebo (n = 1,082) or 850 mg twice daily 1,073). Participants originally continued receive metformin, unmasked, DPPOS (2002-present). Ascertainment development was based fasting 2-h glucose levels after an oral tolerance...
OBJECTIVE Regression from prediabetes to normal glucose regulation (NGR) was associated with reduced incidence of diabetes by 56% over 10 years in participants the Diabetes Prevention Program Outcomes Study (DPPOS). In an observational analysis, we examined whether regression NGR also risk for microvascular disease (MVD). RESEARCH DESIGN AND METHODS Generalized estimating equations were used examine prevalence aggregate MVD at DPPOS year 11 people who regressed least once (vs. never) during...
The Restoring Insulin Secretion (RISE) Consortium is testing interventions designed to preserve or improve β-cell function in prediabetes early type 2 diabetes.β-Cell measured using hyperglycemic clamps and oral glucose tolerance tests (OGTTs). adult medication protocol randomizes participants 12 months of placebo, metformin alone, liraglutide plus metformin, insulin (3 months) followed by (9 months). pediatric metformin. surgical gastric banding (24 Adult inclusion criteria include fasting...
Polycystic ovary syndrome (PCOS) is associated with an increased risk of impaired glucose tolerance and type 2 diabetes. Recent evidence suggests that variation in the gene encoding cysteine protease calpain-10 influences susceptibility to The present study was undertaken determine whether this quantitative traits pertinent pathogenesis PCOS We studied 212 women (124 white European ancestry, 57 African-American, 13 Hispanic, Asian-American, 5 Middle-Eastern). Each subject genotyped for 3 DNA...
Polycystic ovary syndrome (PCOS) and its underlying features remain poorly understood. In this genetic proteomic study, we expand the number of loci from 19 to 29, identify 31 associated plasma proteins. Many risk-increasing were with later age at menopause, underscoring reproductive longevity related a larger functional ovarian reserve. Hormonal regulation in aetiology condition, through metabolic features, was emphasised. The analysis highlighted perturbations metabolically-related biology...
OBJECTIVE We examined the glucose response curves (biphasic [BPh], monophasic [MPh], incessant increase [IIn]) during an oral tolerance test (OGTT) and their relationship to insulin sensitivity (IS) β-cell function (βCF) in youth versus adults with impaired or recently diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS This was both a cross-sectional longitudinal evaluation of participants RISE study randomized metformin alone for 12 months glargine 3 followed by 9 months. At...
Large genome-wide association studies of glycemic traits have identified genetics variants that are associated with insulin resistance (IR) in the general population. It is unknown whether people genetic enrichment for these IR respond differently to interventions aim improve sensitivity. We built a risk score (GRS) based on 17 established and effect sizes (weighted IR-GRS) 2,713 participants Diabetes Prevention Program (DPP) consent. tested associations between weighted IR-GRS sensitivity...
Novel biomarkers of type 2 diabetes (T2D) and response to preventative treatment in individuals with similar clinical risk may highlight metabolic pathways that are important disease development. We profiled 331 metabolites 2,015 baseline plasma samples from the Diabetes Prevention Program (DPP). Cox models were used determine associations between incident T2D, as well whether differed by group (i.e., lifestyle [ILS], metformin [MET], or placebo [PLA]), over an average 3.2 years follow-up....
Animal models exhibiting high homology with humans at the genetic and pathophysiological levels will facilitate identification validation of gene targets underlying asthma. In present study, a nonhuman primate model allergic asthma was developed by sensitizing cynomolgus monkeys to dust mite antigen. Sensitization elevated allergen-specific serum IgE IgG levels, peripheral blood mononuclear cells isolated from sensitized animals released IL-4, IL-5, IL-10, but not IFN-gamma. Aerosolized...
• In the majority of clinical settings, a suppressed serum thyrotropin (s-TSH) level determined by new sensitive assays is diagnostic thyrotoxicosis. This has led to its proposed use as screen for thyroid disease. However, s-TSH may be in conditions other than We retrospectively reviewed measurements made large heterogeneous population determine which settings value could potentially lead misdiagnosis. found that was useful making diagnosis autonomous function and assessment hormone...
Abstract Background To identify genetic associations of quantitative metabolic syndrome (MetS) traits and characterize heterogeneity across ethnic groups. Methods Data was collected from GENetics Noninsulin dependent Diabetes Mellitus (GENNID), a multiethnic resource Type 2 diabetic families included 1520 subjects in 259 African-American, European-American, Japanese-Americans, Mexican-American families. We focused on eight MetS traits: weight, waist circumference, systolic diastolic blood...
Genome-wide significant loci for metformin response in type 2 diabetes reported elsewhere have not been replicated the Diabetes Prevention Program (DPP). To assess pharmacogenetic interactions prediabetes, we conducted a genome-wide association study (GWAS) DPP. Cox proportional hazards models tested associations with incidence (MET; n = 876) and placebo (PBO; 887) arms. Multiple linear regression assessed 1-year change metformin-related quantitative traits, adjusted baseline trait, age,...
EHRMANN, DAVID A.; ROSENFIELD, ROBERT L.; BARNES, RANDALL B.; BRIGELL, DEBORAH F.; SHEIKH, ZUBIE Author Information
It is unclear whether relative elevations in androgens or irregular menses (IM) are associated with greater cardiometabolic risk among women who already overweight and glucose intolerant. We conducted a secondary analysis of the Diabetes Prevention Program (DPP) Outcomes Study (DPPOS). Participants included sex hormone measurements did not use exogenous estrogen (n = 1422). examined free androgen index (FAI) IM was diabetes during DPP/DPPOS coronary artery calcification (CAC) at DPPOS year...