A5100739361- Diabetes, Cardiovascular Risks, and Lipoproteins
- Obesity, Physical Activity, Diet
- Diabetes Management and Research
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Physical Activity and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- Acute Myocardial Infarction Research
- Cardiovascular Disease and Adiposity
- Ovarian function and disorders
- Cardiovascular and exercise physiology
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Health and Lifestyle Studies
- Cardiovascular Function and Risk Factors
- Oral microbiology and periodontitis research
- Cardiac Structural Anomalies and Repair
- Cancer-related gene regulation
Yonsei University
2010-2025
Korea University
2025
Gangnam Severance Hospital
2025
Syracuse University
2019-2024
Baylor University
2022
University of Iowa
2022
Vanderbilt University Medical Center
2022
Twin Cities Orthopedics
2022
University of Minnesota
2022
Nanyang Technological University
2022
The shape of the glucose response curve during an oral tolerance test (OGTT), monophasic versus biphasic, identifies physiologically distinct groups individuals with differences in insulin secretion and sensitivity. We aimed to verify value OGTT-glucose against more sensitive clamp-measured biomarkers type 2 diabetes risk, examine incretin/pancreatic hormones free fatty acid associations these phenotypes obese adolescents without diabetes.A total 277 completed a 2-h OGTT were categorized...
OBJECTIVE Adipose tissue insulin resistance is one of the pathophysiological components type 2 diabetes. Herein we investigated: 1) adipose index (Adipose-IR) (calculated as fasting × free fatty acids [FFAs]) in youth across spectrum adiposity from normal weight to obese and glucose tolerance (NGT) impaired (IGT) diabetes, 2) relationship Adipose-IR with physical metabolic characteristics, 3) predictive power for determining dysglycemia youth. RESEARCH DESIGN AND METHODS A total 205 had...
Objective Youth type 2 diabetes mellitus (T2DM) occurs decades earlier than adult T2DM and is characterized by high therapeutic failure rates decreased response to insulin sensitizers suggesting a more severe disease process in adults. To explain these observations, we hypothesized that resistance worse obese youth adults with impaired glucose tolerance (IGT), state of high-risk for T2DM. As proof-of-concept, compared sensitivity between BMI-, sex-, race-matched vs IGT. Methods This...
OBJECTIVE In adults, the shape of glucose response during an oral tolerance test (OGTT) prospectively and independently predicts type 2 diabetes. However, no reports have described utility this indicator in younger populations. The purpose study was to compare diabetes risk factors Latino adolescents characterized by either a monophasic or biphasic OGTT. RESEARCH DESIGN AND METHODS A total 156 nondiabetic completed 2-h Monophasic groups were compared for following factors: fasting glucose,...
Metabolic flexibility reflects the ability to switch from lipid carbohydrate oxidation during insulin stimulation manifested in increased respiratory quotient (RQ). Little is known about adipose tissue metabolism and metabolic adolescent girls with polycystic ovary syndrome (PCOS). We investigated whole-body lipolysis, substrate oxidation, obese PCOS vs without PCOS. Twenty-one 21 were pair-matched for age race. Body composition, abdominal visceral (VAT), sex hormones, profile, adiponectin...
Despite evidence of insulin resistance and β-cell dysfunction in glucose metabolism youth with prediabetes, the relationship between adipose tissue sensitivity (ATIS) function remains unknown. We investigated whole-body lipolysis, ATIS, relative to ATIS (adipose disposition index [DI]) obese impaired tolerance (IGT) versus normal (NGT). Whole-body lipolysis (glycerol appearance rate [GlyRa], [2H5]glycerol at baseline during a hyperinsulinemic-euglycemic clamp), lipid oxidation (indirect...
The increased occurrence of type 2 diabetes and its clinical correlates is a global public health issue, there are continued efforts to find genetic determinant across ethnically diverse populations. aims this study were determine the heritability metabolic syndrome phenotypes in Arizona Insulin Resistance (AIR) registry perform an association analysis common single nucleotide polymorphisms (SNPs) identified by GWAS with these traits. All participants Mexican Americans from AIR...
OBJECTIVE Obese youth without diabetes with monophasic oral glucose tolerance test (OGTT) response curves have lower insulin sensitivity and impaired β-cell function compared those biphasic curves. The OGTT curve has not been studied in youth-onset type 2 diabetes. Here we the hypothesis that at randomization TODAY (Treatment Options for Type Diabetes Adolescents Youth) study forecasts heightened glycemic failure rates accelerated decline function. RESEARCH DESIGN AND METHODS OGTTs (n = 662)...
OBJECTIVE We examined the glucose response curves (biphasic [BPh], monophasic [MPh], incessant increase [IIn]) during an oral tolerance test (OGTT) and their relationship to insulin sensitivity (IS) β-cell function (βCF) in youth versus adults with impaired or recently diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS This was both a cross-sectional longitudinal evaluation of participants RISE study randomized metformin alone for 12 months glargine 3 followed by 9 months. At...
In adults, 1-h glucose during an oral tolerance test (OGTT) predicts the development of type 2 diabetes independent fasting and 2-h concentrations. The purpose current investigation was to examine utility elevated levels prospectively predict deterioration in β-cell function prediabetes high-risk youth.Obese Latino youth with a family history (133 male 100 female; age 11.1 ± 1.7 years) completed baseline OGTT were divided into two groups based upon threshold 155 mg/dL (<155 mg/dL, n = 151,...
Summary Background The American Diabetes Association recommends risk‐based screening for dysglycaemia (prediabetes and type 2 diabetes) in youth with overweight/obesity plus ≥1 risk factor. However, evidence these recommendations is lacking. Objectives Examine the association between number of factors prevalence at initial presentation. Methods In a paediatric obesity registry, (>10 <20 years old, body mass index ≥85th percentile) were categorized into four groups according to (1, 2, 3...
Obesity, which is caused by various congenital factors, lifestyle changes, and modernized eating habits, has recently emerged as a serious health concern in children adolescents. According to the Korea National Health Nutrition Examination Survey (KNHANES) conducted from 2007 2020, prevalence of obesity overweight youth shown an increasing trend over time. Notably, been studied several studies. However, given its close association with rapidly changing societal environments patterns,...
Obesity is a metabolic disease caused by environmental and genetic factors. However, the epigenetic mechanisms of obesity are incompletely understood. The aim our study was to investigate role skeletal muscle DNA methylation in combination with transcriptomic changes obesity. Muscle biopsies were obtained basally from lean (n = 12; BMI 23.4 ± 0.7 kg/m2) obese 10; 32.9 participants euglycemic-hyperinsulinemic clamps assess insulin sensitivity. We performed reduced representation bisulfite...
Background: Although the effect of fat mass and obesity-associated (FTO) gene on adiposity is well established, there a lack evidence whether physical activity (PA) modifies FTO variants obesity in Latino populations.Therefore, purpose this study was to examine PA influences interactive effects between measures Latinos.Results: After controlling for age sex, participants who did not engage regular exhibited higher BMI, mass, HC, WC with statistical significance (P < 0.001).Although...
Obesity can increase the risk of complex metabolic diseases, including insulin resistance. Moreover, obesity be caused by environmental and genetic factors. However, epigenetic mechanisms are not well defined. Therefore, identification novel biomarkers allows for a more complete understanding disease its underlying The aim our study was to identify DNA methylation changes in whole-blood that were strongly associated with Whole-blood obtained from lean (n = 10; BMI 23.6 ± 0.7 kg/m2) obese...
Among US firefighters, sudden cardiac arrest and psychological stress (i.e., PTSD) are the leading cause of on-duty death. Metabolic syndrome (MetSyn) may influence both cardiometabolic cognitive health. Here, we examined differences in disease risk factors, function, physical fitness firefighters with vs. without MetSyn.One hundred fourteen male aged 20 to 60 years, participated study. MetSyn non-MetSyn were divided by AHA/NHLBI criteria. Of them, performed a paired-match analysis respect...
In adults, the time-to-glucose-peak at or after 30 minutes during an oral glucose tolerance test (OGTT) identifies physiologically distinct groups with differences in insulin sensitivity, β-cell function and risk for type 2 diabetes. obese non-diabetic adolescents, we investigated if OGTT-time-to-glucose-peak also reflects incretin free fatty acid (FFA) responses besides sensitivity function, measured by clamp.Obese adolescents (n = 278) were categorized according to their Early-peak (at...
Parallel with the current pediatric obesity epidemic, escalating rates of youthonset type 2 diabetes mellitus (T2DM) have become a major public health burden. Although lifestyle modification can be first-line prevention for T2DM in youths, there is lack evidence to establish optimal specific exercise strategies obese youths at high risk T2DM. The purpose this narrative review summarize potential impact on key pathophysiological factors T2DM, insulin sensitivity and β-cell function, among...