A5051702821- Parkinson's Disease Mechanisms and Treatments
- Diabetes Management and Research
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Effects and risks of endocrine disrupting chemicals
- Neurological disorders and treatments
- Genomics and Chromatin Dynamics
- Pancreatic function and diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Cardiovascular Function and Risk Factors
- Botulinum Toxin and Related Neurological Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Heart Failure Treatment and Management
- Pharmaceutical studies and practices
- Animal testing and alternatives
- Pesticide Exposure and Toxicity
Michigan State University
2023-2024
Grand Rapids Community College
2024
Children's Hospital of Philadelphia
2019
University of Oklahoma Health Sciences Center
2018
OBJECTIVE Obese youth without diabetes with monophasic oral glucose tolerance test (OGTT) response curves have lower insulin sensitivity and impaired β-cell function compared those biphasic curves. The OGTT curve has not been studied in youth-onset type 2 diabetes. Here we the hypothesis that at randomization TODAY (Treatment Options for Type Diabetes Adolescents Youth) study forecasts heightened glycemic failure rates accelerated decline function. RESEARCH DESIGN AND METHODS OGTTs (n = 662)...
Abstract Parkinson’s disease (PD) is the fastest-growing neurological worldwide, with increases outpacing aging and occurring most rapidly in recently industrialized areas, suggesting a role of environmental factors. Epidemiological, post-mortem, mechanistic studies suggest that persistent organic pollutants, including organochlorine pesticide dieldrin, increase PD risk. In mice, developmental dieldrin exposure causes male-specific exacerbation neuronal susceptibility to...
Abstract Epidemiological studies show that exposure to the organochlorine pesticide dieldrin is associated with an increased risk of Parkinson’s disease (PD). Animal support a link between developmental and neuronal susceptibility in α-synuclein preformed fibril MPTP models adult male C57BL/6 mice. In previous study, we showed was sex-specific changes DNA modifications within genes related dopaminergic neuron development maintenance at 12 wk age. Here, used capture hybridization-sequencing...
Epidemiological studies show that exposure to the organochlorine pesticide dieldrin is associated with increased risk of Parkinson's disease (PD). Animal support a link between developmental and neuronal susceptibility in α-synuclein preformed fibril (α-syn PFF) MPTP models adult male C57BL/6 mice. In previous study, we showed was sex-specific changes DNA modifications within genes related dopaminergic neuron development maintenance at 12 weeks age. Here, used capture...
To understand the factors associated with glycemic control after starting insulin in youth type 2 diabetes following failure (persistent HbA1c ≥8%) metformin alone, + rosiglitazone or lifestyle TODAY study.Change add-on therapy and predictive of response were evaluated. At 1-year postinsulin initiation, 253 had a mean 3.9 ± 1.0 visits since time initiation. Participants divided into three groups according to control: consistent decrease by ≥0.5%, change <0.5%, increase at 75% more...
By Sierra L. Boyd. Parkinson's disease has emerged as the fastest-growing neurological disorder globally, exhibiting a rise that surpasses effects of aging and intensifies in recently industrialized regions, pointing towards potential environmental influences.
Abstract Parkinson’s disease (PD) is the most common movement disorder and one of fastest-growing neurological diseases worldwide. This increase outpaces rate aging rapid in recently industrialized areas, suggesting role environmental factors. Consistent with this, epidemiological studies show an association between exposure to persistent organic pollutants increased risk PD. When combined post-mortem analysis mechanistic studies, a for specific compounds, including organochlorine pesticide...