A5019829980- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Adrenal Hormones and Disorders
- Adrenal and Paraganglionic Tumors
- Thyroid Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Cardiovascular Function and Risk Factors
- Thyroid Cancer Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hormonal Regulation and Hypertension
- Cholesterol and Lipid Metabolism
- Cardiac Imaging and Diagnostics
- Lipid metabolism and disorders
- Neuroendocrine Tumor Research Advances
- Muscle metabolism and nutrition
- Cancer, Hypoxia, and Metabolism
- Drug Transport and Resistance Mechanisms
University of Amsterdam
2016-2025
Amsterdam University Medical Centers
2011-2025
Amsterdam UMC Location University of Amsterdam
2011-2020
Federation of American Societies for Experimental Biology
2020
National Institutes of Health
2020
Yale University
2020
Harvard University
2020
Rockefeller University
2020
Brigham and Women's Hospital
2020
Leiden University Medical Center
2006-2015
Inflammation plays a key role in the pathogenesis of obesity. Chronic overfeeding leads to macrophage infiltration adipose tissue, resulting proinflammatory cytokine production. Both microbial and endogenous danger signals trigger assembly intracellular innate immune sensor Nlrp3, caspase-1 activation production cytokines IL-1β IL-18. Here, we showed that mice deficient apoptosis-associated speck-like protein, were resistant development high-fat diet-induced obesity, which correlated with...
The oxysterol-activated liver X receptor (LXR) provides a link between sterol and fatty acid metabolism; activation of LXR induces transcription lipogenic genes. This study shows that induction the genes Srebp-1c, Fas, Acc1 upon administration synthetic agonist T0901317 to C57BL/6J mice (10 mg/kg/day, 4 days) is associated with massive hepatic steatosis along entire lobule 2.5-fold increase in very low density lipoprotein-triglyceride (VLDL-TG) secretion. increased VLDL-TG secretion was...
Subsequent nights with partial sleep restriction result in impaired glucose tolerance, but the effects on insulin sensitivity have not been characterized.The aim of this study was to evaluate effect a single night parameters sensitivity.Nine healthy subjects (five men, four women) were studied once after normal duration (sleep allowed from 2300 0730 h), and 4 h 0100 0500 h). Sleep characteristics assessed by polysomnography. Insulin measured hyperinsulinemic euglycemic clamp studies (from...
Circadian rhythm disturbances are observed in, e.g., aging and neurodegenerative diseases associated with an increased incidence of obesity diabetes. We subjected male C57Bl/6J mice to constant light [12-h light-light (LL) cycle] examine the effects a disturbed circadian on energy metabolism insulin sensitivity. In vivo electrophysiological recordings in central pacemaker suprachiasmatic nuclei (SCN) revealed immediate reduction amplitude, stabilizing at 44% normal amplitude values after 4 d...
The wealth of clinical epidemiological data on the association between intra-abdominal fat accumulation and morbidity sharply contrasts with paucity knowledge about determinants distribution, which cannot be explained merely in terms humoral factors. If it comes to neuronal control, until now, adipose tissue was reported innervated by sympathetic nervous system only, known for its catabolic effect. We hypothesized presence a parasympathetic input stimulating anabolic processes tissue....
The wealth of clinical epidemiological data on the association between intra-abdominal fat accumulation and morbidity sharply contrasts with paucity knowledge about determinants distribution, which cannot be explained merely in terms humoral factors. If it comes to neuronal control, until now, adipose tissue was reported innervated by sympathetic nervous system only, known for its catabolic effect. We hypothesized presence a parasympathetic input stimulating anabolic processes tissue....
IGF-I is a key factor in intrauterine development and postnatal growth metabolism. The secretion of utero not dependent on GH, whereas childhood adult life, seems to be mainly controlled by as revealed from studies patients with GHRH receptor GH mutations. In 55-yr-old male, the first child consanguineous parents, presenting severe retardation, microcephaly, sensorineural deafness, we found homozygous G A nucleotide substitution gene changing valine 44 into methione. inactivating nature...
At present it is not clear which factors are responsible for the diurnal pattern of plasma leptin levels, although timing food intake and circulating hormones such as glucocorticoids insulin have both been proposed independent determinants. In this study we show that ablation biological clock by thermal lesions hypothalamic suprachiasmatic nucleus (SCN) completely eliminates levels. By contrast, removal corticosterone signal adrenalectomy replacement did affect More importantly, nocturnal...
Survival studies in differentiated thyroid carcinoma (DTC) may be biased because they have been performed heterogeneous populations. In addition, specific death causes DTC not documented well the literature.The aim of our study was to investigate survival and a homogeneous cohort patients.Patients included 366 consecutive patients with who had all treated according same protocol for initial therapy follow-up.Prognostic factors DTC-related were analyzed by univariate Cox regression analysis,...
We have studied eight endurance-trained women at rest and during exercise 25, 65, 85% of maximal oxygen uptake. The rate appearance (R a ) free fatty acids (FFA) was determined by infusion [ 2 H ]palmitate, fat oxidation rates were indirect calorimetry. Glucose kinetics assessed with [6,6- ]glucose. R increased in relation to intensity. In contrast, whereas FFA significantly the same extent low- moderate-intensity exercise, high-intensity reduced compared other values. Carbohydrate...
Interleukin-6 (IL-6) is one of the major circulating cytokines in catabolic states. To investigate its endocrinologic and metabolic actions vivo, we studied eight patients with metastatic renal cell cancer two times, once during infusion saline (control) a 4-h 150 micrograms recombinant human IL-6 (rhIL-6). Rates appearance (Ra) glucose free fatty acids (FFA) plasma were measured by using isotope dilution method. Energy expenditure substrate oxidation determined indirect calorimetry. rhIL-6...
To evaluate the long-term impact of cured Cushing's disease on subjective well-being, we assessed quality life by validated health-related questionnaires in 58 patients from transsphenoidal surgery (n = 58), some whom received additional radiotherapy 11) and/or bilateral adrenalectomy 3). The mean duration remission was 13.4 +/- 6.7 yr (range 2-25 yr). Patient data were compared with a control group 98 healthy subjects same age and sex distribution age-adjusted reference values available...
The long-term impact of acromegaly on subjective well-being after treatment GH excess is unclear. Therefore, we evaluated quality life by validated questionnaires in a cross-sectional study 118 successfully treated acromegalic patients. initial was transsphenoidal surgery most patients (92%), if necessary followed radiotherapy or octreotide. All were remission at the time assessment (GH, <1.9 mug/liter; normal IGF-I for age). General perceived reduced compared with controls all subscales (P...
Treatment options for patients with radioactive iodine (RaI) refractory metastases of differentiated thyroid carcinoma (DTC) are limited. We studied the effects multitarget tyrosine kinase inhibitor sorafenib on reinduction RaI uptake and tumor progression.Open, single center, arm 26-week prospective phase II study open-ended extension.We treated 31 progressive metastatic or locally advanced DTC 400 mg b.i.d. The primary endpoint was at 26 weeks. Additional endpoints were radiological...