A5018999557- Ocular Oncology and Treatments
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Neuroblastoma Research and Treatments
- Herpesvirus Infections and Treatments
- Brain Metastases and Treatment
- Virus-based gene therapy research
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Cancer-related Molecular Pathways
- Cytomegalovirus and herpesvirus research
- CNS Lymphoma Diagnosis and Treatment
- Retinopathy of Prematurity Studies
- Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Corneal Surgery and Treatments
- Cardiac pacing and defibrillation studies
- Histiocytic Disorders and Treatments
- Ethics in Clinical Research
- Eosinophilic Disorders and Syndromes
- Data-Driven Disease Surveillance
- Viral-associated cancers and disorders
- Ear and Head Tumors
- Management of metastatic bone disease
- Cancer Treatment and Pharmacology
Children's Hospital of Philadelphia
2009-2024
University of Pennsylvania
2009-2024
Australian National University
2022
Children's National
2017
University of Alabama at Birmingham
2003-2017
Northwestern University
2017
Washington University in St. Louis
2017
University of Illinois Chicago
2010
St Thomas' Hospital
2001
P.M.N.M. Dental College and Hospital
1979
No approved therapies exist for inoperable plexiform neurofibromas in patients with neurofibromatosis type 1.
To define the clinical and radiologic features of brainstem gliomas (BSGs) in children with neurofibromatosis type 1 (NF1).We performed a retrospective cross-sectional study 133 NF1 concurrent BSGs cared for at 4 referral centers. BSG was determined using radiographic criteria. Age diagnosis, tumor location appearance, symptoms, treatment, presence optic pathway glioma were assessed.The average age diagnosis 7.2 years, tumors occurred most often midbrain medulla (66%). The majority NF1-BSGs...
Background Intravenous chemotherapy (IVC) remains an important globe salvage therapy for retinoblastoma. Methods Evaluation of long-term at 5, 10, 15 and 20 years following frontline IVC Results Of 994 eyes, comparison by International Classification Retinoblastoma group (A vs B C D E) revealed more advanced with older mean age presentation (8 7 10 11 months, p<0.001). By clinical features, demonstrated greater tumour diameter (3.2 6.8 9.4 14.3 16.4, p<0.001) thickness (2.0 3.7 4.4 7.3...
Malignant gliomas are the most common primary brain tumor and characterized by rapid highly invasive growth. Because of their poor prognosis, new therapeutic strategies needed. Oncolytic virotherapy (OV) is a promising strategy for treating cancer that incorporates both direct viral replication mediated immune mechanisms to kill cells. C134 next generation Δγ134.5 oHSV-1 with improved intratumoral replication. It remains safe in CNS environment inducing early IFN signaling which restricts...
Background: Radiation therapy (RT) plays an important role in management of pediatric central nervous system (CNS) malignancies. Centers are increasingly utilizing pencil beam scanning proton (PBS-PT). However, the risk brainstem necrosis has not yet been reported. In this study, we evaluate rate patients with CNS malignancies treated PBS-PT.Material and methods: Pediatric non-hematologic PBS-PT who received dose to were included. All procedures approved by institutional review board....
Abstract Purpose: Retinoblastoma is the most common intraocular malignancy in children. Although new chemotherapeutic approaches have improved ocular salvage rates, novel therapies are required for patients with refractory and metastatic disease. Chimeric antigen receptor (CAR) T cells targeting glypican-2 (GPC2) a potential therapeutic strategy. Experimental Design: GPC2 expression its regulation by E2F1 transcription factor were studied retinoblastoma patient samples cellular models. In...
10062 Background: Retinoblastoma (RB) is the most common childhood eye tumor. Intraocular RB cure rates approach 100%. Therefore, treatment now focuses on globe salvage and preserving functional vision. The Research into Visual Endpoints Health Outcomes After Treatment (RIVERBOAT) consortium was established to examine patient outcomes in transitional era from systemic intraocular therapy. Methods: Patients with treated at 13 North American centers 2008-2022 were identified. Medical record...
The high prevalence of carboplatin hypersensitivity reactions (HSR) significantly affects the treatment pediatric patients with low-grade glioma (LGG). Rechallenging is an option that must balance risks repeat allergic reaction to benefits retaining effective anti-tumor regimen.We performed a retrospective review children LGG treated and vincristine between October 2000 April 2013, who had documented HSR carboplatin. Patients were re-exposed using either precautionary measures (prolonged...
We report two cases of primary CNS lymphoma (PCNSL) treated with high-dose methotrexate. Though standard adult treatment PCNSL incorporates whole-brain radiotherapy, the literature suggests it may be possible to delay or avoid radiotherapy and associated increased risk neurologic sequelae in pediatric patients. Studies adults indicate methotrexate therapy can effective against has advantages over current treatment. Both patients have no evidence disease 9 7 years after treatment, suggesting...
ABSTRACT Previous studies have described in vitro serial passage of a Δγ 1 34.5 herpes simplex virus type (HSV-1) strain SK-N-SH neuroblastoma cells and selection mutants that acquired the ability to infect replicate this previously nonpermissive cell line. Here we describe mutant HSV-1 by vivo passage, which prolongs survival two separate experimental murine brain tumor models. Two conditionally replication-competent viruses, M002, expresses interleukin-12, its parent virus, R3659, were...
To evaluate retinoblastoma control after intravenous chemotherapy (chemoreduction) by patient age at presentation.
Neurofibromatosis type 1 (NF1) is an autosomal dominant cancer predisposition syndrome caused by germline alterations of the NF1 gene. Patients with are at increased risk for developing benign and malignant tumors, such as optic pathway glioma peripheral nerve sheath neoplasms. The number effective therapies neurofibromatosis-related tumors has been historically limited. However, there have recent advances in understanding targeted these mitogen-activated kinase inhibitors multiple tyrosine...
A virulent recombinant HSV lacking the diploid γ(1)34.5 gene (Δγ(1)34.5) have been investigated over last two decades both for anti-tumor therapy and as vaccine vectors. The first generation vectors, while safe, are incapable of sustained replication in majority treated patients. An interferon inducible host antiviral kinase, protein kinase R (PKR), limits late viral synthesis Δγ(1)34.5 viruses. This review describes development new through serial passage selection direct genome engineering,...
Not available.
<p>Supplementary Figure 1. Expression of GPC2 and GD2 in retinoblastoma patient samples cell lines (see related main Fig. 1).</p>
<div>AbstractPurpose:<p>Retinoblastoma is the most common intraocular malignancy in children. Although new chemotherapeutic approaches have improved ocular salvage rates, novel therapies are required for patients with refractory and metastatic disease. Chimeric antigen receptor (CAR) T cells targeting glypican-2 (GPC2) a potential therapeutic strategy.</p>Experimental Design:<p>GPC2 expression its regulation by E2F1 transcription factor were studied retinoblastoma...
<div>AbstractPurpose:<p>Retinoblastoma is the most common intraocular malignancy in children. Although new chemotherapeutic approaches have improved ocular salvage rates, novel therapies are required for patients with refractory and metastatic disease. Chimeric antigen receptor (CAR) T cells targeting glypican-2 (GPC2) a potential therapeutic strategy.</p>Experimental Design:<p>GPC2 expression its regulation by E2F1 transcription factor were studied retinoblastoma...
<p>Supplementary Figure 3. Mouse retina expression of GPC2 and GD2, retinal CAR T-cell infiltration, systemic toxicities, antigen loss in the intraocular model (see related main Fig. 4).</p>