A5100438510- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Medical and Biological Ozone Research
- Organ Transplantation Techniques and Outcomes
- Hydrogen's biological and therapeutic effects
- Acute Kidney Injury Research
- Selenium in Biological Systems
- Epigenetics and DNA Methylation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Ferroptosis and cancer prognosis
- Heme Oxygenase-1 and Carbon Monoxide
- Renal cell carcinoma treatment
- Cancer-related gene regulation
- Dietary Effects on Health
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Abdominal vascular conditions and treatments
- Cancer Mechanisms and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Iron Metabolism and Disorders
- COVID-19 Clinical Research Studies
Xiamen University
2025
Renmin Hospital of Wuhan University
2016-2025
Wuhan University
2016-2025
Second Affiliated Hospital of Fujian Medical University
2013-2024
Fujian Medical University
2013-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Zhongshan Hospital of Xiamen University
2024
University of Hong Kong
2023
Cytel (United States)
2023
Xuzhou Medical College
2013-2023
Ischemia/reperfusion injury (I/R) is one of the leading causes acute kidney (AKI) that typically occurs in renal surgeries. However, I/R still currently lacks effective therapeutic targets. In this study, we proved inhibition Brd4 with its selective inhibitor, JQ1, could exert a protective role mice. Inhibiting either JQ1 or genetic knockdown resulted reduction endoplasmic reticulum stress (ERS)-associated protein and proapoptotic expression both I/R-induced hypoxia/reoxygenation (H/R)...
Abstract COVID-19 is a newly emerging infectious disease, which generally susceptible to human beings and has caused huge losses people's health. Acute respiratory distress syndrome (ARDS) one of the common clinical manifestations severe it also responsible for current shortage ventilators worldwide. This study aims analyze characteristics ARDS patients establish diagnostic system based on artificial intelligence (AI) method predict probability in patients. We collected data 659 from 11...
The radioresistant signature of colorectal cancer (CRC) hampers the clinical utility radiotherapy. Here, we find that fecal microbiota transplantation (FMT) potentiates tumoricidal effects radiation and degrades intertwined adverse events in azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced CRC mice. FMT cumulates Roseburia intestinalis (R. intestinalis) gastrointestinal tract. Oral gavage R. assembles at site synthetizes butyrate, sensitizing to alleviating intestinal toxicity primary...
Abstract Background Several parameters driving the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain unclear, including age-specific differences in infectivity and susceptibility, contribution inapparent infections to transmission. Robust estimates key time-to-event distributions scarce as well. Methods We collected individual records for 1,178 SARS-CoV-2 infected individuals their 15,648 contacts identified by contact tracing monitoring over period from...
Abstract Acute kidney injury (AKI) is mainly caused by renal ischaemia reperfusion (IRI). Lots of evidence suggests that ferroptosis and oxidative stress play the vital role in IRI. However, specific mechanism IRI has not been fully elucidated. lysine‐specific demethylase 1 (LSD1) shown to regulate pathogenesis disease. In this study, we firstly found LSD1 was positively related TCP, a classical inhibitor, could alleviate tissue damage induced Inhibition with either TCP or knockdown both...
Overweight, obesity, and related diseases are currently the major public health problems worldwide. Astilbin, extracted from rhizome of Smilax glabra Roxb., is known to have significant anti-inflammatory activity hepatoprotective effect. Studies shown that it can inhibit adipogenesis in adipocytes vitro; however, intervention benefits astilbin against obesity along with its associated mechanisms remain unknown. This study aimed demonstrate impact consumption on overall biochemical pattern...
The pathogenetic mechanisms underlying ischemia-reperfusion (I/R) injury involve oxidative stress, inflammation and apoptosis. Nesfatin-1, a novel peptide, has been reported to possess antioxidant, anti-inflammatory anti-apoptic properties. study was examine the potential protective effects of nesfatin-1 on renal I/R injury.I/R model induced by placing clamp across left artery for 45 min followed 24 h reperfusion, along with contralateral nephrectom. Twenty-four rats divided into three...
The novel biomarker, neutrophil percentage-to-albumin ratio (NPAR), as a prognostic tool for inflammation in relation to all-cause mortality patients afflicted by strokes has yet be explored.Data sets associated with patient files stored within the MIMIC-III V1.4 database were obtained. Data from 940-patients obtained this retrospective analysis. Clinical endpoints determined represent month (30-), three months (90-) and year (365-) stroke determined. In order determine NPAR clinical...
Renal ischemia reperfusion injury (RIRI) is an inevitable complication during renal surgery. Histone deacetylase 6 (HDAC6), a key member of the histone family, associated with multiple pathologies, including diseases. However, whether HDAC6 could become potential therapeutic target for clinical application RIRI remained to be proven. Here, we found that expression was abnormally enhanced by transcription factor OSR2 in RIRI. Moreover, were first validate selective degrader,...
Our investigation utilized a two-sample Mendelian randomization approach to explore the ambiguous bidirectional relationship between Chronic Obstructive Pulmonary Disease (COPD) and depression, furthering insights from existing observational studies. In this study, we conducted using genome-wide association studies (GWAS) datasets. We initially analyzed depression data Psychiatric Genomics Consortium UK Biobank (n = 500,199), alongside COPD FinnGen 329,552). The second phase involved...
Abstract Renal fibrosis is considered to be the ultimate pathway for various chronic kidney disease, with a complex etiology and great therapeutic challenges. Tripartite motif-containing (TRIM) family proteins have been shown involved in fibrotic diseases, but whether TRIM39 plays role renal remain unexplored. In this study, we investigated of its molecular mechanism. expression was analyzed patients’ specimens, HK-2 cells unilateral ureteral obstruction (UUO) mice were used functional...
Picroside II possesses a wide range of pharmacological effects and has been demonstrated to ameliorate cerebral ischemia reperfusion (I/R) injury. However, its on renal I/R injury remain unclear. In the present study, role picroside in attenuating oxidative stress inflammatory response rat model was investigated. Sprague Dawley rats were subjected 45 min followed by 24 h reperfusion. Prior reperfusion, treated with or an equal volume phosphate-buffered saline. Renal function histological...
Abstract Prostate cancer (PCa), the second most mortal from developed countries, presents a high level of chemoresistance. There is emerging evidence underscores critical role autophagy in onset, progression, and chemoresistance PCa. In present study, we investigated possible novel regulator, activating molecule beclin1-regulated autophagy1 (Ambra1), ATG gene sensitivity or PCa cells to cisplatin. We explored regulation by Ambra1 manipulation on induction apoptosis human DU145 presence...
Acute kidney injury (AKI) emerges as an acute and critical disease. Tripartite motif 8 (TRIM8), one number of the TRIM protein family, is proved to participate in ischemia/reperfusion (I/R) injury. However, whether TRIM8 involved renal I/R associated mechanisms are currently unclear.This study aimed investigate precise role relevant injury.In this study, human proximal tubular epithelial cells (HK-2 cells) underwent 12 hours hypoxia 2 h, 3 h or 4 reoxygenation establish vitro...
Renal ischemia and reperfusion (I/R) injury, which commonly occurs in kidney transplantation, is the leading cause of acute injury. Picroside II possesses a wide range pharmacological effects, including anti-apoptosis effects. In present study, ability picroside to attenuate apoptosis rat model renal I/R injury was investigated. Sprague-Dawley rats were subjected 45 min followed by 24 h reperfusion. Prior reperfusion, treated with or an equal volume phosphate-buffered saline. It observed...