A5103047943- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Obstructive Sleep Apnea Research
- COVID-19 and Mental Health
- Acute Myocardial Infarction Research
- COVID-19 Digital Contact Tracing
- Viral Infections and Outbreaks Research
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiovascular and Diving-Related Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Heart Rate Variability and Autonomic Control
- Mental Health Research Topics
- COVID-19 Clinical Research Studies
- Vitamin D Research Studies
- COVID-19 Pandemic Impacts
- Cardiovascular Function and Risk Factors
- Respiratory viral infections research
- Chronic Disease Management Strategies
- Neurofibromatosis and Schwannoma Cases
- Viral gastroenteritis research and epidemiology
Capital Medical University
2010-2025
Beijing Anzhen Hospital
2016-2025
Peking University
2020-2024
Jinhua Academy of Agricultural Sciences
2024
Fudan University
2014-2024
Beijing University of Civil Engineering and Architecture
2024
Beijing Tian Tan Hospital
2021-2024
Beijing Institute of Water
2021-2024
National Clinical Research Center for Digestive Diseases
2021-2024
Ministry of Education of the People's Republic of China
2024
Having adopted a dynamic zero-COVID strategy to respond SARS-CoV-2 variants with higher transmissibility since August 2021, China is now considering whether, and for how long, this policy can remain in place. The debate has thus shifted towards the identification of mitigation strategies minimizing disruption healthcare system case nationwide epidemic. To aim, we developed an age-structured stochastic compartmental susceptible-latent-infectious-removed-susceptible model transmission...
This retrospective study was designed to explore whether neutrophil lymphocyte ratio (NLR) is a prognostic factor in patients with coronavirus disease 2019 (COVID-19). A cohort of COVID-19 admitted the Tongren Hospital Wuhan University from 11 January 2020 3 March retrospectively analyzed. Patients hematologic malignancy were excluded. The NLR calculated by dividing count count. values measured at time admission. primary outcome all-cause in-hospital mortality. multivariate logistic analysis...
Abstract Several mechanisms driving SARS-CoV-2 transmission remain unclear. Based on individual records of 1178 potential infectors and their 15,648 contacts in Hunan, China, we estimated key parameters. The mean generation time was to be 5.7 (median: 5.5, IQR: 4.5, 6.8) days, with infectiousness peaking 1.8 days before symptom onset, 95% events occurring between 8.8 9.5 after onset. Most occurred during the pre-symptomatic phase (59.2%). susceptibility infection increases age, while...
COVID-19 vaccination is being conducted in over 200 countries and regions to control SARS-CoV-2 transmission return a pre-pandemic lifestyle. However, understanding when non-pharmaceutical interventions (NPIs) can be lifted as immunity builds up remains key question for policy makers. To address this, we built data-driven model of China. We estimated that, prevent the escalation local outbreaks widespread epidemics, stringent NPIs need remain place at least one year after start vaccination....
Abstract Dynamically adapting the allocation of COVID-19 vaccines to evolving epidemiological situation could be key reduce burden. Here we developed a data-driven mechanistic model SARS-CoV-2 transmission explore optimal vaccine prioritization strategies in China. We found that time-varying vaccination program (i.e., allocating different target groups as epidemic evolves) can highly beneficial it is capable simultaneously achieving objectives (e.g., minimizing number deaths and infections)....
Nonpharmaceutical interventions to control SARS-CoV-2 spread have been implemented with different intensity, timing, and impact on transmission. As a result, post-lockdown COVID-19 dynamics are heterogeneous difficult interpret. We describe set of contact surveys performed in four Chinese cities (Wuhan, Shanghai, Shenzhen, Changsha) during the pre-pandemic, lockdown periods quantify changes patterns. In period, mean number contacts increased by 5 17% as compared period. However, it remains...
Abstract Background All countries are facing decisions about which population groups to prioritize for access COVID-19 vaccination after the first vaccine products have been licensed, at time supply shortages inevitable. Our objective is define key target populations, their size, and priority a program in context of China. Methods On basis utilitarian egalitarian principles, we estimate size tiered phased introduction vaccination, considering evolving goals as supplies increase, detailed...
The impact of sex on the association obstructive sleep apnoea (OSA) with recurrent cardiovascular events following acute coronary syndrome (ACS) remains uncertain. This study sought to examine between OSA and long-term outcomes in women men ACS.In this prospective cohort study, we recruited 2160 ACS patients undergoing portable monitoring June 2015 January 2020. primary end-point was major adverse cerebrovascular event (MACCE), including death, myocardial infarction, stroke, ischaemia-driven...
Background Hypertension is common and leads to negative outcomes. Intensive blood pressure (BP) lowering can reduce cardiovascular events all‐cause mortality, but its benefits for patients with hypertension multiple comorbidities are uncertain. This study aimed explore how affect the clinical outcomes of intensive BP in participants from SPRINT (Systolic Blood Pressure Intervention Trial). Methods We analyzed data set calculated each patient's comorbidity score using Charlson Comorbidity...
Abstract Background Several parameters driving the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain unclear, including age-specific differences in infectivity and susceptibility, contribution inapparent infections to transmission. Robust estimates key time-to-event distributions scarce as well. Methods We collected individual records for 1,178 SARS-CoV-2 infected individuals their 15,648 contacts identified by contact tracing monitoring over period from...
Abstract Background The COVID-19 epidemic originated in Wuhan City of Hubei Province December 2019 and has spread throughout China. Understanding the fast evolving epidemiology transmission dynamics outbreak beyond would provide timely information to guide intervention policy. Methods We collected individual on 8,579 laboratory-confirmed cases from official publically sources reported outside mainland China, as February 17, 2020. estimated temporal variation demographic characteristics key...
Abstract Importance Whether herd immunity through mass vaccination is sufficient to curb SARS-CoV-2 transmission requires an understanding of the duration vaccine-induced immunity, and necessity timing booster doses. Objective: To evaluate immune persistence two priming doses CoronaVac, immunogenicity safety a third dose in healthy adults ≥60 years. Design, setting, participants: We conducted vaccine study built on single-center, randomized, double-blind phase 1/2 trial two-dose schedule...
Background Patients with acute coronary syndrome without standard modifiable cardiovascular risk factors (SMuRFs; hypertension, smoking, dyslipidemia, diabetes) have not been well studied, little known about their characteristics, quality of care, or outcomes. We sought to systematically analyze patients ACS SMuRFs, especially evaluate the effectiveness guideline‐directed medical therapy for these patients. Methods and Results In CCC‐ACS (Improving Care Cardiovascular Disease in China‐Acute...
The coronavirus disease 2019 (COVID-19) pandemic and the measures taken by authorities to control its spread have altered human behavior mobility patterns in an unprecedented way. However, it remains unclear whether population response a COVID-19 outbreak varies within city or among demographic groups. Here, we utilized passively recorded cellular signaling data at spatial resolution of 1 km × for over 5 million users epidemiological surveillance collected during severe acute respiratory...
Background The circadian rhythm of myocardial infarction (MI) in patients with obstructive sleep apnea (OSA) remains disputable and no studies have directly evaluated the relationship between nocturnal hypoxemia MI. aim current study was to evaluate association OSA MI onset during night. Methods Patients OSA‐acute coronary syndrome (ACS) project (NCT03362385) were recruited. time identified by patient's report chest pain that prompted hospital admission. All underwent an overnight using a...
Abstract Background To allow a return to pre-COVID-19 lifestyle, virtually every country has initiated vaccination program mitigate severe disease burden and control transmission. However, it remains be seen whether herd immunity will within reach of these programs. Methods We developed data-driven model SARS-CoV-2 transmission for China, population with low prior from natural infection. The is calibrated considering COVID-19 history the estimated transmissibility Delta variant. Three...
China is facing substantial risks of imported coronavirus disease 2019 (COVID-19) cases and a domestic resurgence in the long run, COVID-19 vaccination expected to be long-lasting solution end pandemic. We aim estimate size target population for at provincial level mainland China, summarize current progress programs, which could support local governments timely determination adjustment policies promotional measures. conducted descriptive study entire between December 2020 August 2021. By...
The mortality following ST-segment elevation myocardial infarction (STEMI) remains substantial in the reperfusion era. Shenfu injection, as a traditional Chinese herbal formula, can alleviate ischemia-reperfusion injury through multiple pharmacologic effects. However, no robust data are available regarding role of injection reducing infarct size for patients with STEMI undergoing primary percutaneous coronary intervention (PPCI).This RESTORE trial is multicenter, randomized, double-blind,...
Abstract Non-pharmaceutical interventions to control COVID-19 spread have been implemented in several countries with different intensity, timing, and impact on transmission. As a result, post-lockdown dynamics are heterogenous difficult interpret. Here we describe set of contact surveys performed four Chinese cities (Wuhan, Shanghai, Shenzhen, Changsha) during the pre-pandemic, lockdown, period quantify transmission relaxing via changes age-specific patterns. We estimate that mean number...