A5101545918- Per- and polyfluoroalkyl substances research
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- SARS-CoV-2 and COVID-19 Research
- Sarcoma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Estrogen and related hormone effects
- Vaccine Coverage and Hesitancy
- Air Quality and Health Impacts
- Axon Guidance and Neuronal Signaling
- Respiratory Support and Mechanisms
- Tumors and Oncological Cases
- Atmospheric chemistry and aerosols
- Pregnancy and preeclampsia studies
- Testicular diseases and treatments
- Viral Infections and Vectors
- Carcinogens and Genotoxicity Assessment
- Surgical site infection prevention
- Birth, Development, and Health
- Viral-associated cancers and disorders
- DNA and Nucleic Acid Chemistry
- Cancer-related Molecular Pathways
- Immune Response and Inflammation
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
China Jiliang University
2022-2025
Chinese Academy of Sciences
2025
First Affiliated Hospital of Fujian Medical University
2018-2025
Fujian Medical University
2018-2025
China Agricultural University
2023-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Children's Oncology Group
2022-2023
University of Florida
2019-2022
Nanjing Normal University
2022
Dalian Medical University
2022
A vaccine against COVID-19 is urgently needed for older adults, in whom morbidity and mortality due to the disease are increased. We aimed assess safety, tolerability, immunogenicity of a candidate vaccine, CoronaVac, containing inactivated SARS-CoV-2, adults aged 60 years older.We did randomised, double-blind, placebo-controlled, phase 1/2 clinical trial CoronaVac healthy Renqiu (Hebei, China). Vaccine or placebo was given by intramuscular injection two doses (days 0 28). Phase 1 comprised...
Commonly used in vitro fertilization protocols produce pregnancies without a corpus luteum (CL), major source of reproductive hormones. In CL showed deficient gestational increases central (aortic) arterial compliance during the first trimester and were at increased risk for developing preeclampsia. Here, we investigated whether there was generalized impairment cardiovascular adaptation compared with conceived spontaneously or through ovarian stimulation, which lead to 1 >1 CL,...
Cardiovascular function is impaired and preeclampsia risk elevated in women conceiving by vitro fertilization (IVF) the absence of a corpus luteum (CL). Here, we report serial evaluation hormones other circulating factors who conceived with (or without) IVF. After prepregnancy baseline, study participants ( n = 19–24/cohort) were evaluated six times during pregnancy once postpartum (~1.6 yr). IVF pregnancies stratified protocol CL number, i.e., ovarian stimulation (>1 CL) or...
Abstract Importance Whether herd immunity through mass vaccination is sufficient to curb SARS-CoV-2 transmission requires an understanding of the duration vaccine-induced immunity, and necessity timing booster doses. Objective: To evaluate immune persistence two priming doses CoronaVac, immunogenicity safety a third dose in healthy adults ≥60 years. Design, setting, participants: We conducted vaccine study built on single-center, randomized, double-blind phase 1/2 trial two-dose schedule...
RNA viruses cause numerous infectious diseases in humans and animals. The crosstalk between the innate DNA sensing pathways attracts increasing attention. Recent studies showed that cGAS-STING pathway plays an important role restricting via mitochondria (mtDNA) mediated activation. However, mechanisms of cGAS immune evasion by remain unknown. Here, we report seneca valley virus (SVV) protease 3C disrupts mtDNA cleaving porcine (pcGAS) a species-specific manner. Mechanistically, W/Q motif...
Diet‑induced obesity is associated with systemic inflammation, which considered to originate predominantly from the adipose tissue. Quercetin and resveratrol are two dietary polyphenols that exhibit anti‑inflammatory properties anti‑insulin resistance when administered in isolation or combination (CQR). It remains unknown whether CQR reduces high fat diet (HFD)‑induced inflammation rats. In current study, 46 male Wistar rats were divided into groups, one of was fed a normal (ND, 5.4% fat,...
Background Most children with intermediate‐risk rhabdomyosarcoma (RMS) have gross disease (group III) at the initiation of chemotherapy. Delayed primary excision (DPE) after induction chemotherapy allows for a reduction in adjuvant radiation dose, but risk potential surgical morbidity. The objectives this study were to compare outcomes group III RMS who did and not undergo DPE assess Methods included 369 patients had clinical sites amenable from Children's Oncology Group studies D9803...
As alternatives of perfluorooctanoic acid (PFOA), hexafluoropropylene oxide dimeric (HFPO-DA) and trimeric (HFPO-TA) have been detected increasingly in environmental media even humans. They shown to exhibit reproductive toxicity model species, but their effects on human remain unclear due the knowledge gap mode action. Herein, (anti-)androgenic two HFPOs PFOA were investigated underlying toxicological mechanism was explored by combining zebrafish test, cell assay molecular docking...
Neonicotinoid insecticides (NNIs) can harm non-target species. This study examines NNIs’ distribution, sources, human exposure risks, and ecological risks in the Qiantang River’s water sediment. NNIs concentrations ranged from 8.92 to 88.0 ng/L 0.55 16.6 ng/g dw The showed a trend of middle reaches > lower upper reaches. Agricultural activities were main source, followed by wastewater treatment plants. Infants had highest intake, with daily intake 15.4 ng/kg body weight, about 5.4-times...
Introduction Per- and poly-fluoroalkyl substances (PFAS) are of great concern due to harm human wildlife health. Local-scale studies, especially those focused on ecologically important or densely populated areas, critical effective management, such as prioritizing resource allocation. Methods To prioritize management efforts, we investigated the distribution PFAS in a coastal plain water network area east China, followed by health ecological risk assessments. Results demonstrated that...
Background: The COVID-19 vaccine for children and adolescents, who are indispensable populations to curb the pandemic, would protect this population against rare severe infectious conditions. Here we aimed assess safety, tolerability immunogenicity of a candidate vaccine, CoronaVac, containing inactivated SARS-CoV-2, in adolescents aged 3-17 years old. Methods: We did randomised, double-blind, placebo-controlled phase 1/2 clinical trial CoronaVac healthy old Zanhuang (Hebei, China). Vaccine...
Abstract Background Treatment of children and adolescents with alveolar rhabdomyosarcoma (ARMS) regional nodal involvement (N1) have been approached differently by North American European cooperative groups. In order to define a better therapeutic strategy, we analyzed two studies conducted between 2005 2016 the paediatric Soft tissue sarcoma Study Group (EpSSG) Children's Oncology (COG). Methods We retrospectively identified patients ARMS N1 enrolled in either EpSSG RMS2005 or COG ARST0531....
Abstract Rhabdomyosarcoma (RMS) is a well‐described cancer in Li–Fraumeni syndrome, resulting from germline TP53 pathogenic variants (PVs). RMS exhibiting anaplasia (anRMS) are associated with high rate of PVs. This study provides updated estimates the prevalence PVs (3%) and anRMS (11%) large cohort ( n = 239) enrolled five Children's Oncology Group (COG) clinical trials. Although patients this series much lower than previously reported, remains elevated. Germline evaluation for should be...
Inflammasomes play pivotal roles in inflammation by processing and promoting the secretion of IL-1β. Caspase-1 is involved maturation IL-1β IL-18, while human caspase-4 specifically processes IL-18. Recent structural studies bound to Pro-IL-18 reveal molecular basis activation caspase-4. However, mechanism caspase-1 pro-IL-1β other IL-1β-converting enzymes remains elusive. Here, we observed that swine Pro-IL-1β (sPro-IL-1β) exists as an oligomeric precursor unlike monomeric (hPro-IL-1β)....