A5053990524- interferon and immune responses
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Viral Infections and Vectors
- Inflammasome and immune disorders
- Computational Drug Discovery Methods
- Ubiquitin and proteasome pathways
- SARS-CoV-2 and COVID-19 Research
- Protein Structure and Dynamics
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Enzyme Structure and Function
- RNA and protein synthesis mechanisms
- T-cell and B-cell Immunology
- Mosquito-borne diseases and control
- RNA Research and Splicing
- Cell death mechanisms and regulation
- RNA regulation and disease
- Viral Infections and Immunology Research
- HIV Research and Treatment
- Plant Molecular Biology Research
- Hepatitis C virus research
- Trace Elements in Health
- Toxin Mechanisms and Immunotoxins
- Influenza Virus Research Studies
Texas A&M University
2016-2025
Fudan University
2012-2025
Minhang District Central Hospital
2025
Mitchell Institute
2025
University of Shanghai for Science and Technology
2017-2018
California Institute of Technology
2007
Princeton University
2002-2005
Office of Basic Energy Sciences
2002-2003
Fred Hutch Cancer Center
1999-2002
Chinese Academy of Sciences
2001
The STING (stimulator of interferon genes) protein can bind cyclic dinucleotides to activate the production type I interferons and inflammatory cytokines. be bacterial second messengers c-di-GMP c-di-AMP, 3’5’-3’5’ GMP-AMP (3’3’ cGAMP) produced by Vibrio cholerae metazoan messenger 2’5’-3’5’ Cyclic (2’3’ cGAMP). Analysis single nucleotide polymorphism (SNP) data from 1000 Genome Project revealed that R71H-G230A-R293Q (HAQ) occurs in 20.4%, R232H 13.7%, G230A-R293Q (AQ) 5.2%, R293Q 1.5% human...
Abstract Immunotherapy is one of the key strategies for cancer treatment. The cGAS-cGAMP-STING-IRF3 pathway cytosolic DNA sensing plays a pivotal role in antiviral defense. We report that STING activator cGAMP possesses significant antitumor activity mice by triggering STING-dependent directly. enhances innate immune responses inducing production cytokines such as interferon-β, interferon-γ and stimulating dendritic cells activation, which induces cross-priming CD8 + T cells. mechanism was...
The recent outbreak of Zika virus (ZIKV) has infected over 1 million people in 30 countries. ZIKV replicates its RNA genome using virally encoded replication proteins. Nonstructural protein 5 (NS5) contains a methyltransferase for capping and polymerase viral synthesis. Here we report the crystal structures full-length NS5 domain at 3.0 Å resolution. structure striking similarities to related Japanese encephalitis virus. in-line pockets substrate binding active site. Key residues are located...
Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, exact immunostimulatory features mtDNA and kinetics detection by cytosolic nucleic acid sensors remain poorly defined. Here, we show that mitochondrial genome instability promotes Z-form accumulation. Z-DNA binding protein 1 (ZBP1) stabilizes nucleates complex containing cGAS, RIPK1, RIPK3 to sustain STAT1 phosphorylation type I interferon (IFN-I) signaling. Elevated mtDNA, ZBP1 expression, IFN-I signaling...
Previous studies of HLA-E allelic polymorphism have indicated that balancing selection may be acting to maintain two major alleles in most populations, indicating a functional difference exist between the alleles. The differ at only one amino acid position, where an arginine position 107 HLA-E*0101 (E<sup>R</sup>) is replaced by glycine HLA-E*0103 (E<sup>G</sup>). To investigate possible differences, we undertaken study physical and biochemical properties these proteins. By comparing...
Significance Type I IFNs are key cytokines involved in antiviral immunity. A number of innate sensing pathways regulate the induction type IFNs. These converge at activation transcription factor IRF-3 (IFN regulatory 3). Three different adaptors mediate recruitment using a conserved structural motif. In this study, we determined molecular mechanisms by which these recruit upon phosphorylation, mechanism activation, and how rotavirus subverts signaling to evade immune surveillance. results...
The RIG-I-like receptors (RLRs), RIG-I and MDA5, recognize single-stranded RNA with 5' triphosphates double-stranded (dsRNA) to initiate innate antiviral immune responses. LGP2, a homolog of MDA5 that lacks signaling capability, regulates the RLRs. To establish structural basis dsRNA recognition by RLRs, we have determined 2.0-A resolution crystal structure human LGP2 C-terminal domain bound an 8-bp dsRNA. Two molecules bind termini minimal contacts between protein molecules. Gel filtration...
The COVID-19 pathogen, SARS-CoV-2, requires its main protease (SC2MPro ) to digest two of translated long polypeptides form a number mature proteins that are essential for viral replication and pathogenesis. Inhibition this vital proteolytic process is effective in preventing the virus from replicating infected cells therefore provides potential treatment option. Guided by previous medicinal chemistry studies about SARS-CoV-1 (SC1MPro ), we have designed synthesized series SC2MPro inhibitors...