A5065304532- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- GDF15 and Related Biomarkers
- Protein Structure and Dynamics
- Enzyme Structure and Function
- Metabolism and Genetic Disorders
- Various Chemistry Research Topics
- Food composition and properties
- Metalloenzymes and iron-sulfur proteins
- Mitochondrial Function and Pathology
- Immunotherapy and Immune Responses
- Macrophage Migration Inhibitory Factor
- Immune Cell Function and Interaction
- RNA and protein synthesis mechanisms
- Nutrition and Health in Aging
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microbial Metabolic Engineering and Bioproduction
- Natural Products and Biological Research
- Protein Hydrolysis and Bioactive Peptides
- Alzheimer's disease research and treatments
- T-cell and B-cell Immunology
- biodegradable polymer synthesis and properties
- Analytical Chemistry and Chromatography
- Peptidase Inhibition and Analysis
- Molecular spectroscopy and chirality
University of Akron
2014-2024
National Institutes of Health
2019-2024
Auburn University
2024
National Heart Lung and Blood Institute
2019-2024
Fred Hutch Cancer Center
1999-2001
Rose–Hulman Institute of Technology
2000
Mead Johnson (United States)
1946-1950
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The mitochondrial, or intrinsic, apoptosis pathway is regulated mainly by members of the B-cell lymphoma 2 (BCL-2) protein family. BCL-2-associated X regulator (BAX) plays a pivotal role in initiation mitochondria-mediated as one factors causing mitochondrial outer-membrane permeabilization (MOMP). Of current interest are endogenous BAX ligands that inhibit its MOMP activity. Mitochondrial-derived peptides (MDPs) recently identified class retrograde signaling molecules and reported to be...
Hydroxyzine in doses of 1.2 - 20 mgm./kgm. intravenously caused a transient fall arterial blood pressure and inhibited the pressor response to epinephrine cats under pentobarbital anesthesia. Hydroxyzine reduced incidence duration ventricular arrhythmias treated with harman methosulfate epinephrine. Hydroxyzine increased coronary flow perfused cat's heart hearts dogs anesthesia. The femoral vessels were also dilated by hydroxyzine. Epinephrine-induced automaticity papillary muscles...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpecific Effects of Certain Tissue Extracts on the Crystallization Pattern Cupric Chloride.Daniel Luzon. Morris and Carol Tilden. MorrisCite this: J. Phys. Chem. 1939, 43, 5, 623–629Publication Date (Print):May 1, 1939Publication History Published online1 May 2002Published inissue 1 1939https://doi.org/10.1021/j150392a007Request reuse permissionsArticle Views34Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are COUNTER-compliant sum...
Members of the B-cell lymphoma (BCL-2) protein family regulate mitochondrial outer membrane permeabilization (MOMP), a phenomenon in which mitochondria become porous and release death-propagating complexes during early stages apoptosis. Pro-apoptotic BCL-2 proteins oligomerize at MOMP, inducing pore formation. Of current interest are endogenous factors that can inhibit pro-apoptotic translocation oligomerization. A mitochondrial-derived peptide, Humanin (HN), was reported being expressed...
In a recerlt paper on the isolation of glycogen from maize (I), it was stated, "The cupric chloride crystallization pattern is very similar to, but not identical with, that. sweet corn extracts.However, hhe preparations indistinguishable that animal sources."The implication something which modifies patbern occurs, together with glycogen, in corn.The nature t,his "something" made clear during attempts to purify polysaccharide responsible for crystal obtained extracts oats (cf.( 2)).In course...
Presented here is a novel method for encapsulating proteins into biodegradable, thermoresponsive coacervate-type polyesters. Bovine serum albumin (BSA) was efficiently incorporated coacervate droplets via simple encapsulation mechanism. Tunable modular systems such as the one presented may be useful in range of protein delivery applications.
Mitochondrial-derived peptides are encoded by mitochondrial DNA but have biological activity outside mitochondria. Eight of these sequences within the 12S and 16S ribosomal genes: humanin, MOTS-c, six SHLP peptides, SHLP1-SHLP6. These various effects in cell culture animal models, affecting neuroprotection, insulin sensitivity, apoptosis, some secreted, potentially having extracellular signaling roles. However, except for their importance normal function is unknown. To gauge importance,...
We conceptually replicated the one previous study (see record 2009-13549-001) revealing that individuals who practice a motor skill under psychological pressure (anxiety training-AT) avoid performance deterioration when exposed to higher levels of pressure. used >3× larger sample size than original and attempted shed light on mechanisms whereby AT may promote by measuring variables related three theories choking pressure: attentional control theory (ACT), reinvestment theory, biopsychosocial...
α-Amidinoazadi(benzopyrro)methenes were synthesized using the Re(CO)3 unit as a templating agent. The products of these template reactions are six-coordinate rhenium complexes, with facial arrangement carbonyls, noncoordinating anion, and tridentate α-amidinoazadi(benzopyrro)methene ligand. ligand shows conversion one diiminoisoindoline sp2 carbon to sp3 carbon, which has been seen in "helmet" bicyclic phthalocyanines. bidentate fragment tilts out plane coordination. Five examples...
A statutory inspection of Burnhope Reservoir completed under Section 10(3) the Reservoirs Act 1975 noted that 30 inch washout valve at outlet tunnel portal had not been tested for some time. measure in interests safety was to simply open and close over its full range prove operability. However, is located on 40 supply main, which provides both a raw water treatment works (WTW) can also be used emergency drawdown. Should fail, consequence would loss pressure WTW, shut down. To maintain...
Selective hits for the glutaredoxin ortholog of Brucella melitensis are determined using STD NMR and verified by trNOE (15)N-HSQC titration. The most promising hit, RK207, was docked into target molecule a scoring function to compare simulated poses experimental data. After elucidating possible poses, hit further optimized lead compound extension with an electrophilic acrylamide warhead. We believe that focusing on selectivity in this early stage drug discovery will limit cross-reactivity...