A5101542421- Sodium Intake and Health
- Nutritional Studies and Diet
- Influenza Virus Research Studies
- Blood Pressure and Hypertension Studies
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Viral Infections and Outbreaks Research
- COVID-19 Digital Contact Tracing
- Liver Disease Diagnosis and Treatment
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Consumer Attitudes and Food Labeling
- Adolescent Sexual and Reproductive Health
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Hepatitis C virus research
- Catalytic C–H Functionalization Methods
- Rabies epidemiology and control
- Alcohol Consumption and Health Effects
- HIV-related health complications and treatments
- Virology and Viral Diseases
- Bacillus and Francisella bacterial research
Indiana University School of Medicine
2024-2025
Southern Medical University
2022-2025
Nanfang Hospital
2022-2025
Indiana University – Purdue University Indianapolis
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2024
China United Network Communications Group (China)
2024
Southern University of Science and Technology
2024
Fourth Affiliated Hospital of China Medical University
2024
China Medical University
2024
Fu Wai Hospital
2024
Abstract Several mechanisms driving SARS-CoV-2 transmission remain unclear. Based on individual records of 1178 potential infectors and their 15,648 contacts in Hunan, China, we estimated key parameters. The mean generation time was to be 5.7 (median: 5.5, IQR: 4.5, 6.8) days, with infectiousness peaking 1.8 days before symptom onset, 95% events occurring between 8.8 9.5 after onset. Most occurred during the pre-symptomatic phase (59.2%). susceptibility infection increases age, while...
Alcohol-associated liver disease (ALD) is a growing global health concern and its prevalence severity are increasing steadily. While bacterial endotoxin translocation into the portal circulation well-established key factor, recent evidence highlights critical role of sterile inflammation, triggered by diverse stimuli, in alcohol-induced injury. This review provides comprehensive analysis complex interactions within hepatic microenvironment ALD. It examines contributions both parenchymal...
OBJECTIVES: To estimate the HIV incidence and assess behavioral, clinical, quality-of-life risk factors for transmission among serodiscordant couples from Henan Province, China. METHODS: Between January 2006 December 2008, initially seronegative spouses were tested at six month intervals. Retrospectively identified subjects interviewed through face-to-face questionnaire. Cox proportional-hazards model was used to relationship between seroconversion. RESULTS: Out of 1927 couples, 84 (4.3%)...
Abstract Background Several parameters driving the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain unclear, including age-specific differences in infectivity and susceptibility, contribution inapparent infections to transmission. Robust estimates key time-to-event distributions scarce as well. Methods We collected individual records for 1,178 SARS-CoV-2 infected individuals their 15,648 contacts identified by contact tracing monitoring over period from...
The association of 24 h urinary Na and potassium excretion with the risk metabolic syndrome (MetS) has not been studied in China. aim present study was to examine this by analysing data from 1906 participants living north To end, urine samples were collected. Of participants, 471 (24·7 %) had MetS. mean K 228·7 40·8 mmol/d, respectively. After multivariate adjustment, odds MetS significantly increased across increasing tertiles (1·00, 1·40 1·54, respectively). For components MetS, central...
Despite therapy with potent antiviral agents, chronic hepatitis B (CHB) patients remain at high risk of hepatocellular carcinoma (HCC). While metabolites have been rediscovered as active drivers biological processes including carcinogenesis, the specific modulating HCC in CHB are largely unknown. Here, we demonstrate that baseline plasma from who later developed during follow-up exhibits growth-promoting properties a case-control design nested within large-scale, prospective cohort....
Background: Chronic alcohol consumption leads to lipid accumulation, oxidative stress, cellular damage, and inflammation in the liver, collectively referred as alcohol-associated liver disease (ALD). FAF2/UBXD8/ETEA (Fas-associated factor 2) is a ubiquitin ligase adaptor protein that plays crucial role ubiquitin-mediated degradation of misfolded proteins endoplasmic reticulum. A recent genome-wide association study indicated an between FAF2 ALD; however, exact contribution ALD pathogenesis...
Objectives: To estimate the potential health benefits, costs, and cost-effectiveness of mandating a limit on industrial trans-fatty acids (iTFA) in all foods, fats, oils China. Methods: A multiple cohort proportional multistate life table model was used to project impact eliminating dietary iTFA ischemic heart disease (IHD) burden costs over different time horizons (5 years, 10 population lifetime). Nationally representative data intake were derived from 2015-2018 China Total Diet Study...
To describe the quality of life and related factors in HIV-positive spouses undergoing ART from discordant couples.A cross-sectional study was conducted among 1,009 serodiscordant couples Zhumadian, Henan Province, between October 1, 2008 March 31, 2009. were interviewed by local health professionals. Quality evaluated WHOQOL (Chinese Version). A multiple linear regression model used to analyze factors.The majority subjects female (56.39%), had received a high school education (44%), Han...
<b><i>Background/Aims:</i></b> High sodium intake and low of potassium can increase blood pressure (BP) risk developing hypertension. Few studies have examined the association between 24-h urinary excretion BP or hypertension in China, most used only a single sample. <b><i>Methods:</i></b> We analyzed data on 2281 participants aged 18-69 years by using two excretions from supplemental baseline survey Shandong-Ministry Health Action Salt...
Abstract Objective To examine the association of 24 h urinary Na excretion and Na:K with obesity in Chinese adults. Design Population-based cross-sectional study using a four-stage stratified sampling strategy. Setting Shandong Province, China. Subjects adults ( n 1906) aged 18–69 years who provided complete urine samples. Results Odds increased significantly across increasing quartiles (1·00, 1·54, 1·69 2·52, respectively, for overweight; 1·00, 1·20, 1·50, 2·03, obesity; 1·44, 1·85 2·53,...
Salt substitutes are edible salts that contain less sodium chloride owing to its partial substitution with other minerals, which serve as an important and effective intervention public health strategy targeting hypertension secondary diseases, despite a small degree of controversy.This study aimed identify the current salt substitute initiatives in various nations intergovernmental organizations (IGOs) worldwide summarize their types characteristics.A scoping review was performed based on...
The biogenesis and clinical application of serum HBV pgRNA have been a research hotspot in recent years. This study further characterized the heterogeneity 3' terminus capsid RNA by utilizing variety experimental systems conditionally supporting genome replication secretion, reveal that truncation is catalyzed cellular ribonuclease(s) viral RNaseH at positions after before DR1, respectively, indicating DR1 as boundary between encapsidated portion for reverse transcription unprotected...
Hepatitis B virus (HBV) exploits the endosomal sorting complexes required for transport (ESCRT)/multivesicular body (MVB) pathway virion budding. In addition to enveloped virions, HBV-replicating cells nonlytically release non-enveloped (naked) capsids independent of integral ESCRT machinery, but exact secretory mechanism remains elusive. Here, we provide more detailed information about existence and characteristics naked capsid, as well viral host regulations capsid egress. HBV capsid/core...
The first human infections of novel avian influenza A(H7N9) virus were identified in China March 2013. Sentinel surveillance systems and contact tracing may not identify mild asymptomatic virus.We assessed the seroprevalence antibodies to three populations during early stages epidemic.From 2013 May 2014, we collected sera from general population, poultry workers, contacts confirmed nine Chinese provinces reporting and, for contacts, second 2-3 weeks later. We screened by advanced...
Current studies regarding glucocorticosteroid treatment of influenza have only estimated risk critical illness or death which can be easily confounded by timing administration. We used severe acute respiratory infection (sARI) as an endpoint and investigated associated with receiving glucocorticosteroids before sARI onset.sARI cases were defined influenza-like (ILI) pH1N1 distress. Controls other than randomly selected from the community. compared medications onset using a matched case...
To examine the risk of cigarette smoking on cardiovascular disease (CVD) and all-cause mortality among hypertensive patients.We conducted a prospective cohort study 36,943 patients aged at least 40 years. Data other variables were obtained in 1991 follow-up evaluation was 1999-2000.During median 8.2 years, we documented 7194 deaths 36 943 patients. Compared with never-smokers, multivariate-adjusted relative risks (MRRs) [95% confidence intervals (CIs)] for CVD 1.19 (1.07, 1.31) 1.33 (1.23,...
Abstract Low sodium salt (LSS) is an effective way to reduce the primary source of from home cooking. To investigate availability, price and characteristics LSS, gap between LSS regular salt, potential size subsidy needed equalize salt. A market survey salts was conducted using two major online shopping sites JD Taobao November December 2022. Of 360 salts, 76 (21.1%) are 284 (78.9%) The average proportion potassium chloride low (16.8%), half brands contain less than 15% only 6.6% contains...
A practical, convenient, and highly selective method of synthesizing β-ketonitriles from the Pd-catalyzed addition organoboron reagents to dinitriles has been developed. This provides excellent functional-group tolerance, a broad scope substrates, convenience using commercially available substrates. The is expected show further utility in future synthetic procedures.