A5100458780- Histone Deacetylase Inhibitors Research
- Antibiotic Resistance in Bacteria
- Receptor Mechanisms and Signaling
- Protein Degradation and Inhibitors
- Chemical Synthesis and Analysis
- Heat shock proteins research
- ATP Synthase and ATPases Research
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Antimicrobial agents and applications
- thermodynamics and calorimetric analyses
- Enzyme Catalysis and Immobilization
- Neurological Complications and Syndromes
- Diabetes Treatment and Management
- Mass Spectrometry Techniques and Applications
- Neurobiology and Insect Physiology Research
- Microbial Natural Products and Biosynthesis
- Pancreatic function and diabetes
- Asthma and respiratory diseases
- Neuropeptides and Animal Physiology
- Plant Virus Research Studies
- Ion channel regulation and function
- Peptidase Inhibition and Analysis
- Fungal and yeast genetics research
- Glycosylation and Glycoproteins Research
Chinese Academy of Sciences
2025
Institute of Deep-Sea Science and Engineering
2025
Renmin Hospital of Wuhan University
2023
Bengbu Medical College
2023
Wuhan University
2023
Harbin Medical University
2022
Second Affiliated Hospital of Harbin Medical University
2022
ZheJiang Institute For Food and Drug Control
2021-2022
East China Normal University
2018-2021
Pfizer (United States)
2011
Renal ischemia reperfusion injury (RIRI) is an inevitable complication during renal surgery. Histone deacetylase 6 (HDAC6), a key member of the histone family, associated with multiple pathologies, including diseases. However, whether HDAC6 could become potential therapeutic target for clinical application RIRI remained to be proven. Here, we found that expression was abnormally enhanced by transcription factor OSR2 in RIRI. Moreover, were first validate selective degrader,...
Following interrogation of a wide-ligand profile database, nonselective norepinephrin reuptake inhibitor was converted into novel muscarinic antagonist using two medicinal chemistry transformations (M3/NRI selectivity >1000). Conjugation to β(2) agonist motif furnished molecule with balanced dual pharmacology, as demonstrated in guinea pig trachea tissue model bronchoconstriction. This approach provides new starting points for the treatment chronic obstructive pulmonary disease and...
Abstract In essence, the β 2 adrenergic receptor (β AR) plays an antiproliferative role by increasing intracellular cyclic 3’,5’-adenosine monophosphate (cAMP) concentration through G αs coupling, but interestingly, AR antagonists are able to effectively inhibit fibroblast-like synoviocytes (FLSs) proliferation, thus ameliorating experimental RA, indicating that signalling pathway is impaired in RA FLSs via unknown mechanisms. The local epinephrine (Epi) level was found be much higher...
Objective To explore the effect and molecular mechanism of HDAC inhibitor SNDX-275 inhibiting cell proliferation in ErbB2-overexpressing breast cancer BT474 cells. Methods Breast cells were treated with SNDX-275, setting as test group, line phosphate buffered saline (PBS) control. The concentration 0, 0.5, 1.0, 2.0, 3.0, 4.0 μmol/L respectively. Cell was analyzed by MTS assay colony formation assay, expressions ErbB2, ErbB3, p-Akt Western blotting, miR-125a, miR-125b RT-PCR. After...
Supplementary Figure from Antitumor Activity of a Mitochondrial-Targeted HSP90 Inhibitor in Gliomas
Abstract Objectives: Polymyxins are antibacterial polypeptides used as “last resort” therapy option for multidrug-resistant Gram-negative bacteria. The expansion of polymyxin-resistant infections has inspired development novel polymyxin derivatives, and deacylation is one the critical steps in generating those antibiotics. Deacylase from Actinoplanes utahensis hydrolyze acyl moieties echinocandins, also efficiently deacylates daptomycin, ramoplanin other important Here, deacylase was studied...
Primitive neuroectodermal tumors (PNET) are rare malignant tumors, but the mortality rate of patients is extremely high. The aim this study was to identify hub genes and pathways involved in pathogenesis PNET screen potential small molecule drugs for PNET. We extracted gene expression profiles from Gene Expression Omnibus database identified differentially expressed (DEGs) through Limma package R. Two (GSE14295 GSE74195) were downloaded, including 33 5 cases separately. Four hundred...